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Septic arthritis as a non-surgical complication in rheumatoid arthritis: relation to disease severity and therapy

Östensson, A and Geborek, Pierre LU (1991) In British Journal of Rheumatology 30(1). p.35-38
Abstract
More aggressive therapy including cytotoxic drugs is increasingly used in the treatment of rheumatoid arthritis (RA), and may confer increased susceptibility to infections. Septic arthritis is one infectious complication known to be overrepresented in RA. We studied the impact of disease severity and medication in a group of nine RA patients with proven septic arthritis, excluding those occurring as a complication of orthopaedic surgery. Two control groups were used for comparison. The septic arthritis patients were functionally more incapacitated and more often treated with cytotoxic drugs. Six of the nine septic arthritis patients had received an intra-articular injection into the infected joint within 3 months prior to the onset of the... (More)
More aggressive therapy including cytotoxic drugs is increasingly used in the treatment of rheumatoid arthritis (RA), and may confer increased susceptibility to infections. Septic arthritis is one infectious complication known to be overrepresented in RA. We studied the impact of disease severity and medication in a group of nine RA patients with proven septic arthritis, excluding those occurring as a complication of orthopaedic surgery. Two control groups were used for comparison. The septic arthritis patients were functionally more incapacitated and more often treated with cytotoxic drugs. Six of the nine septic arthritis patients had received an intra-articular injection into the infected joint within 3 months prior to the onset of the septic arthritis. Only one of these occurred immediately after arthrocentesis. The annual frequency of septic arthritis was approximately 0.2%. During the 4-year period studied the frequency was 0.5%. When related to the number of glucocorticosteroid injections, a frequency of 1 per 2000 injections was found when late septic arthritis was included. The high frequency of delayed septic arthritis after intra-articular glucocorticosteroid administration should alert physicians to this complication. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Rheumatoid arthritis, Septic arthritis, Cytostatics, Immunosuppression, Glucocortico-steroid, Functional class, Arthrocentesis
in
British Journal of Rheumatology
volume
30
issue
1
pages
35 - 38
publisher
Oxford University Press
external identifiers
  • pmid:1991215
  • scopus:0025765780
ISSN
0263-7103
language
English
LU publication?
yes
id
95bd1d23-98d8-4a32-ab4d-cf73060521cb (old id 1105974)
alternative location
http://rheumatology.oxfordjournals.org/cgi/reprint/30/1/35
date added to LUP
2008-08-01 12:19:47
date last changed
2017-08-27 03:57:06
@article{95bd1d23-98d8-4a32-ab4d-cf73060521cb,
  abstract     = {More aggressive therapy including cytotoxic drugs is increasingly used in the treatment of rheumatoid arthritis (RA), and may confer increased susceptibility to infections. Septic arthritis is one infectious complication known to be overrepresented in RA. We studied the impact of disease severity and medication in a group of nine RA patients with proven septic arthritis, excluding those occurring as a complication of orthopaedic surgery. Two control groups were used for comparison. The septic arthritis patients were functionally more incapacitated and more often treated with cytotoxic drugs. Six of the nine septic arthritis patients had received an intra-articular injection into the infected joint within 3 months prior to the onset of the septic arthritis. Only one of these occurred immediately after arthrocentesis. The annual frequency of septic arthritis was approximately 0.2%. During the 4-year period studied the frequency was 0.5%. When related to the number of glucocorticosteroid injections, a frequency of 1 per 2000 injections was found when late septic arthritis was included. The high frequency of delayed septic arthritis after intra-articular glucocorticosteroid administration should alert physicians to this complication.},
  author       = {Östensson, A and Geborek, Pierre},
  issn         = {0263-7103},
  keyword      = {Rheumatoid arthritis,Septic arthritis,Cytostatics,Immunosuppression,Glucocortico-steroid,Functional class,Arthrocentesis},
  language     = {eng},
  number       = {1},
  pages        = {35--38},
  publisher    = {Oxford University Press},
  series       = {British Journal of Rheumatology},
  title        = {Septic arthritis as a non-surgical complication in rheumatoid arthritis: relation to disease severity and therapy},
  volume       = {30},
  year         = {1991},
}