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Evidence of fibre hyperplasia in human skeletal muscles from healthy young men? A left-right comparison of the fibre number in whole anterior tibialis muscles

Sjostrom, M; Lexell, Jan LU ; Eriksson, A and Taylor, C C (1991) In European Journal of Applied Physiology and Occupational Physiology 62(5). p.301-304
Abstract
Cross-sections (thickness 10 microns) of whole autopsied left and right anterior tibialis muscles of seven young previously healthy right-handed men (mean age 23 years, range 18-32 years) were prepared for light-microscope enzyme histochemistry. Muscle cross-sectional area and total number of fibres, mean fibre size (indirectly determined) and proportion of the different fibre types (type 1 and type 2 on basis of myofibrillar adenosine triphosphatase characteristics), in each muscle cross-section were determined. The analysis showed that the cross-sectional area of the left muscle was significantly larger (P less than 0.05), and the total number of fibres was significantly higher (P less than 0.05), than for the corresponding right muscle.... (More)
Cross-sections (thickness 10 microns) of whole autopsied left and right anterior tibialis muscles of seven young previously healthy right-handed men (mean age 23 years, range 18-32 years) were prepared for light-microscope enzyme histochemistry. Muscle cross-sectional area and total number of fibres, mean fibre size (indirectly determined) and proportion of the different fibre types (type 1 and type 2 on basis of myofibrillar adenosine triphosphatase characteristics), in each muscle cross-section were determined. The analysis showed that the cross-sectional area of the left muscle was significantly larger (P less than 0.05), and the total number of fibres was significantly higher (P less than 0.05), than for the corresponding right muscle. There was no significant difference for the mean fibre size or the proportion of the two fibre types. The results imply that long-term asymmetrical low-level daily demands on muscles of the left and the right lower leg in right-handed individuals provide enough stimuli to induce an enlargement of the muscles on the left side, and that this enlargement is due to an increase in the number of muscle fibres (fibre hyperplasia). Calculations based on the data also explain why the underlying process of hyperplasia is difficult, or even impossible, to detect in standard muscle biopsies. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Muscle, Muscle fibres, Histocytochemistry, Hyperplasia, Handedness
in
European Journal of Applied Physiology and Occupational Physiology
volume
62
issue
5
pages
301 - 304
publisher
Springer
external identifiers
  • pmid:1874233
  • scopus:0025760927
ISSN
0301-5548
DOI
10.1007/BF00634963
language
English
LU publication?
no
id
b619a4ec-bd30-4d39-a286-f9491d334858 (old id 1105995)
date added to LUP
2008-08-01 12:47:17
date last changed
2017-08-06 04:35:11
@article{b619a4ec-bd30-4d39-a286-f9491d334858,
  abstract     = {Cross-sections (thickness 10 microns) of whole autopsied left and right anterior tibialis muscles of seven young previously healthy right-handed men (mean age 23 years, range 18-32 years) were prepared for light-microscope enzyme histochemistry. Muscle cross-sectional area and total number of fibres, mean fibre size (indirectly determined) and proportion of the different fibre types (type 1 and type 2 on basis of myofibrillar adenosine triphosphatase characteristics), in each muscle cross-section were determined. The analysis showed that the cross-sectional area of the left muscle was significantly larger (P less than 0.05), and the total number of fibres was significantly higher (P less than 0.05), than for the corresponding right muscle. There was no significant difference for the mean fibre size or the proportion of the two fibre types. The results imply that long-term asymmetrical low-level daily demands on muscles of the left and the right lower leg in right-handed individuals provide enough stimuli to induce an enlargement of the muscles on the left side, and that this enlargement is due to an increase in the number of muscle fibres (fibre hyperplasia). Calculations based on the data also explain why the underlying process of hyperplasia is difficult, or even impossible, to detect in standard muscle biopsies.},
  author       = {Sjostrom, M and Lexell, Jan and Eriksson, A and Taylor, C C},
  issn         = {0301-5548},
  keyword      = {Muscle,Muscle fibres,Histocytochemistry,Hyperplasia,Handedness},
  language     = {eng},
  number       = {5},
  pages        = {301--304},
  publisher    = {Springer},
  series       = {European Journal of Applied Physiology and Occupational Physiology},
  title        = {Evidence of fibre hyperplasia in human skeletal muscles from healthy young men? A left-right comparison of the fibre number in whole anterior tibialis muscles},
  url          = {http://dx.doi.org/10.1007/BF00634963},
  volume       = {62},
  year         = {1991},
}