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The capsaicin-induced inflammatory reaction in the cat eye: antagonism by ruthenium red

Andersson, Sven LU and Almegård, Birgitta (1991) In Experimental Eye Research 52(5). p.519-523
Abstract
The neurogenic ocular inflammatory response in the cat was investigated by means of intracameral injections of capsaicin. At a dose of 200 micrograms intracamerally the eye responded with a breakdown of the blood-aqueous barrier (BAB) and a transient ocular hypertension. A response of the same magnitude was observed when a dose of 1 microgram capsaicin was given. Most of the response to this lower dose was prevented by ruthenium red, an inorganic dye thought specifically to antagonize the effects of capsaicin on sensory nerve endings. Following injection of 200 micrograms capsaicin there was a transient increase in pupil size, but this response was not seen after 1 microgram. Repeated injections of 200 micrograms capsaicin when the effects... (More)
The neurogenic ocular inflammatory response in the cat was investigated by means of intracameral injections of capsaicin. At a dose of 200 micrograms intracamerally the eye responded with a breakdown of the blood-aqueous barrier (BAB) and a transient ocular hypertension. A response of the same magnitude was observed when a dose of 1 microgram capsaicin was given. Most of the response to this lower dose was prevented by ruthenium red, an inorganic dye thought specifically to antagonize the effects of capsaicin on sensory nerve endings. Following injection of 200 micrograms capsaicin there was a transient increase in pupil size, but this response was not seen after 1 microgram. Repeated injections of 200 micrograms capsaicin when the effects of the first dose had vanished resulted in tachyphylaxis of the mydriatic response. A dose of 200 micrograms of capsaicin had no effect on resistance in the outflow routes for aqueous humour. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
blood-aqueous barrier, capsaicin, cat eye, intra-ocular pressure, neurogenic inflammation, outflow facility, ruthenium red
in
Experimental Eye Research
volume
52
issue
5
pages
519 - 523
publisher
Elsevier
external identifiers
  • pmid:1712311
  • scopus:0025809203
ISSN
0014-4835
DOI
10.1016/0014-4835(91)90052-G
language
English
LU publication?
no
id
7253a392-7161-49da-b8a3-d132f65ba85a (old id 1106141)
date added to LUP
2008-08-01 09:01:09
date last changed
2017-01-01 04:38:24
@article{7253a392-7161-49da-b8a3-d132f65ba85a,
  abstract     = {The neurogenic ocular inflammatory response in the cat was investigated by means of intracameral injections of capsaicin. At a dose of 200 micrograms intracamerally the eye responded with a breakdown of the blood-aqueous barrier (BAB) and a transient ocular hypertension. A response of the same magnitude was observed when a dose of 1 microgram capsaicin was given. Most of the response to this lower dose was prevented by ruthenium red, an inorganic dye thought specifically to antagonize the effects of capsaicin on sensory nerve endings. Following injection of 200 micrograms capsaicin there was a transient increase in pupil size, but this response was not seen after 1 microgram. Repeated injections of 200 micrograms capsaicin when the effects of the first dose had vanished resulted in tachyphylaxis of the mydriatic response. A dose of 200 micrograms of capsaicin had no effect on resistance in the outflow routes for aqueous humour.},
  author       = {Andersson, Sven and Almegård, Birgitta},
  issn         = {0014-4835},
  keyword      = {blood-aqueous barrier,capsaicin,cat eye,intra-ocular pressure,neurogenic inflammation,outflow facility,ruthenium red},
  language     = {eng},
  number       = {5},
  pages        = {519--523},
  publisher    = {Elsevier},
  series       = {Experimental Eye Research},
  title        = {The capsaicin-induced inflammatory reaction in the cat eye: antagonism by ruthenium red},
  url          = {http://dx.doi.org/10.1016/0014-4835(91)90052-G},
  volume       = {52},
  year         = {1991},
}