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The effects of calcitonin gene-related peptide (CGRP) on cochlear and mucosal blood flow in the albino rabbit

Hillerdal, Maria and Andersson, Sven LU (1991) In Hearing Research 52(2). p.321-328
Abstract
The effects of intravenously infused calcitonin gene-related peptide (CGRP) on the regional blood flow of the cochlea, the middle ear and the upper respiratory tract were studied. Two series of experiments were performed without pretreatment on either conscious or pentobarbital anaesthetized animals; in one series the cervical sympathetic chain was severed on one side; in another series anaesthetized animals were subjected to ganglionic blockade with hexamethonium bromide in order to abolish reflexes involving the autonomic nervous system. In still another series conscious animals were pretreated with indomethacin in order to reduce the formation of prostaglandins. In all groups of animals where sympathetic influence was diminished... (More)
The effects of intravenously infused calcitonin gene-related peptide (CGRP) on the regional blood flow of the cochlea, the middle ear and the upper respiratory tract were studied. Two series of experiments were performed without pretreatment on either conscious or pentobarbital anaesthetized animals; in one series the cervical sympathetic chain was severed on one side; in another series anaesthetized animals were subjected to ganglionic blockade with hexamethonium bromide in order to abolish reflexes involving the autonomic nervous system. In still another series conscious animals were pretreated with indomethacin in order to reduce the formation of prostaglandins. In all groups of animals where sympathetic influence was diminished cochlear blood flow increased during the infusion of CGRP. In the mucosa of middle ear and the upper airways, the blood flow increased in all groups. The results indicate that CGRP at these doses causes vasorelaxation in the mucosa of the middle ear and upper airways and does so also in the cochlea if the sympathetic influence is abolished. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cochlea, Mucosa, Upper respiratory tract, Middle ear, Blood flow, Microsphere method, CGRP, Rabbit
in
Hearing Research
volume
52
issue
2
pages
321 - 328
publisher
Elsevier
external identifiers
  • pmid:2061223
  • scopus:0025778602
ISSN
0378-5955
DOI
10.1016/0378-5955(91)90022-2
language
English
LU publication?
no
id
8c06a429-0c7e-4721-8225-bd846b2d885f (old id 1106143)
date added to LUP
2008-08-01 09:03:23
date last changed
2017-01-01 05:07:09
@article{8c06a429-0c7e-4721-8225-bd846b2d885f,
  abstract     = {The effects of intravenously infused calcitonin gene-related peptide (CGRP) on the regional blood flow of the cochlea, the middle ear and the upper respiratory tract were studied. Two series of experiments were performed without pretreatment on either conscious or pentobarbital anaesthetized animals; in one series the cervical sympathetic chain was severed on one side; in another series anaesthetized animals were subjected to ganglionic blockade with hexamethonium bromide in order to abolish reflexes involving the autonomic nervous system. In still another series conscious animals were pretreated with indomethacin in order to reduce the formation of prostaglandins. In all groups of animals where sympathetic influence was diminished cochlear blood flow increased during the infusion of CGRP. In the mucosa of middle ear and the upper airways, the blood flow increased in all groups. The results indicate that CGRP at these doses causes vasorelaxation in the mucosa of the middle ear and upper airways and does so also in the cochlea if the sympathetic influence is abolished.},
  author       = {Hillerdal, Maria and Andersson, Sven},
  issn         = {0378-5955},
  keyword      = {Cochlea,Mucosa,Upper respiratory tract,Middle ear,Blood flow,Microsphere method,CGRP,Rabbit},
  language     = {eng},
  number       = {2},
  pages        = {321--328},
  publisher    = {Elsevier},
  series       = {Hearing Research},
  title        = {The effects of calcitonin gene-related peptide (CGRP) on cochlear and mucosal blood flow in the albino rabbit},
  url          = {http://dx.doi.org/10.1016/0378-5955(91)90022-2},
  volume       = {52},
  year         = {1991},
}