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Cerebroelectrical depression following surfactant treatment in preterm neonates

Hellström-Westas, Lena LU ; Bell, A H; Skov, L; Greisen, G and Svenningsen, N W (1992) In Pediatrics 89(4 Pt 1). p.643-647
Abstract
During surfactant treatment of respiratory distress syndrome, 23 premature newborns were investigated with continuous amplitude-integrated electroencephalography (cerebral function monitors). Simultaneously, arterial blood pressure and transcutaneous blood gas values were recorded. A short (less than 10 minutes) but significant decrease in cerebral activity was seen in almost all neonates immediately after the surfactant instillation, in spite of an improved pulmonary function. In 21 of 23 neonates, a transient fall in mean arterial blood pressure of 9.3 mm Hg (mean) occurred coincidently with the cerebral reaction. Neonates in whom intraventricular hemorrhage developed tended to have lower presurfactant mean arterial blood pressure (P... (More)
During surfactant treatment of respiratory distress syndrome, 23 premature newborns were investigated with continuous amplitude-integrated electroencephalography (cerebral function monitors). Simultaneously, arterial blood pressure and transcutaneous blood gas values were recorded. A short (less than 10 minutes) but significant decrease in cerebral activity was seen in almost all neonates immediately after the surfactant instillation, in spite of an improved pulmonary function. In 21 of 23 neonates, a transient fall in mean arterial blood pressure of 9.3 mm Hg (mean) occurred coincidently with the cerebral reaction. Neonates in whom intraventricular hemorrhage developed tended to have lower presurfactant mean arterial blood pressure (P greater than .05), but they had a significantly lower mean arterial blood pressure after surfactant instillation (P less than .05). No other differences were found between neonates in whom intraventricular hemorrhage developed and those without intraventricular hemorrhage. The present findings demonstrate that an acute cerebral dysfunction may occur after surfactant instillation. In some vulnerable neonates with arterial hypotension and severe pulmonary immaturity, the fall in mean arterial blood pressure may increase the risk of cerebral complications and could be related to an unchanged rate of intraventricular hemorrhage after surfactant treatment. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatrics
volume
89
issue
4 Pt 1
pages
643 - 647
publisher
American Academy of Pediatrics
external identifiers
  • pmid:1557244
  • scopus:0026528559
ISSN
1098-4275
language
English
LU publication?
yes
id
c3821e25-4a8e-4783-8e23-4cc31c082d38 (old id 1106166)
alternative location
http://pediatrics.aappublications.org/cgi/content/abstract/89/4/643
date added to LUP
2008-08-01 16:04:47
date last changed
2017-08-20 04:21:52
@article{c3821e25-4a8e-4783-8e23-4cc31c082d38,
  abstract     = {During surfactant treatment of respiratory distress syndrome, 23 premature newborns were investigated with continuous amplitude-integrated electroencephalography (cerebral function monitors). Simultaneously, arterial blood pressure and transcutaneous blood gas values were recorded. A short (less than 10 minutes) but significant decrease in cerebral activity was seen in almost all neonates immediately after the surfactant instillation, in spite of an improved pulmonary function. In 21 of 23 neonates, a transient fall in mean arterial blood pressure of 9.3 mm Hg (mean) occurred coincidently with the cerebral reaction. Neonates in whom intraventricular hemorrhage developed tended to have lower presurfactant mean arterial blood pressure (P greater than .05), but they had a significantly lower mean arterial blood pressure after surfactant instillation (P less than .05). No other differences were found between neonates in whom intraventricular hemorrhage developed and those without intraventricular hemorrhage. The present findings demonstrate that an acute cerebral dysfunction may occur after surfactant instillation. In some vulnerable neonates with arterial hypotension and severe pulmonary immaturity, the fall in mean arterial blood pressure may increase the risk of cerebral complications and could be related to an unchanged rate of intraventricular hemorrhage after surfactant treatment.},
  author       = {Hellström-Westas, Lena and Bell, A H and Skov, L and Greisen, G and Svenningsen, N W},
  issn         = {1098-4275},
  language     = {eng},
  number       = {4 Pt 1},
  pages        = {643--647},
  publisher    = {American Academy of Pediatrics},
  series       = {Pediatrics},
  title        = {Cerebroelectrical depression following surfactant treatment in preterm neonates},
  volume       = {89},
  year         = {1992},
}