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Mother-to-infant transmission of hepatitis C virus

Wejstål, R; Widell, Anders LU ; Månsson, Ann-Sofie LU ; Hermodsson, S and Norkrans, G (1992) In Annals of Internal Medicine 117(11). p.887-890
Abstract
OBJECTIVE: To describe the rate of perinatal transmission of hepatitis C virus (HCV). DESIGN: Follow-up study of newborn children of mothers with chronic HCV infection. SETTING: A university hospital in Sweden. PARTICIPANTS: Fourteen women with chronic HCV infection and their 21 newly born children. MAIN OUTCOME MEASURES: Detection of HCV RNA in serum by the polymerase chain reaction and detection of anti-HCV antibody by second generation assays. RESULTS: All mothers were found to be positive for anti-HCV antibody both by second-generation enzyme-linked immunosorbent assay (ELISA) and by second-generation recombinant immunoblot assay (RIBA-2); all also had detectable serum HCV RNA. Two children had long-lasting alanine aminotransferase... (More)
OBJECTIVE: To describe the rate of perinatal transmission of hepatitis C virus (HCV). DESIGN: Follow-up study of newborn children of mothers with chronic HCV infection. SETTING: A university hospital in Sweden. PARTICIPANTS: Fourteen women with chronic HCV infection and their 21 newly born children. MAIN OUTCOME MEASURES: Detection of HCV RNA in serum by the polymerase chain reaction and detection of anti-HCV antibody by second generation assays. RESULTS: All mothers were found to be positive for anti-HCV antibody both by second-generation enzyme-linked immunosorbent assay (ELISA) and by second-generation recombinant immunoblot assay (RIBA-2); all also had detectable serum HCV RNA. Two children had long-lasting alanine aminotransferase (ALT) elevations, and one of them became HCV RNA positive. None of the other children developed biochemical hepatitis. However, two additional children had temporary viremia. Only the child with biochemical and biopsy-proven hepatitis and detectable HCV RNA in multiple blood samples actively produced anti-HCV antibody. CONCLUSIONS: Mother-to-infant transmission of HCV infection from chronically infected women without human immunodeficiency virus (HIV) infection seems to be uncommon. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of Internal Medicine
volume
117
issue
11
pages
887 - 890
publisher
American College of Physicians
external identifiers
  • pmid:1332562
  • scopus:0026456671
ISSN
0003-4819
language
English
LU publication?
yes
id
36f50b5a-31a8-4758-bf09-f2a10f780f97 (old id 1106176)
alternative location
http://www.annals.org/content/117/11/887.abstract
date added to LUP
2008-08-11 14:58:46
date last changed
2017-08-06 03:49:41
@article{36f50b5a-31a8-4758-bf09-f2a10f780f97,
  abstract     = {OBJECTIVE: To describe the rate of perinatal transmission of hepatitis C virus (HCV). DESIGN: Follow-up study of newborn children of mothers with chronic HCV infection. SETTING: A university hospital in Sweden. PARTICIPANTS: Fourteen women with chronic HCV infection and their 21 newly born children. MAIN OUTCOME MEASURES: Detection of HCV RNA in serum by the polymerase chain reaction and detection of anti-HCV antibody by second generation assays. RESULTS: All mothers were found to be positive for anti-HCV antibody both by second-generation enzyme-linked immunosorbent assay (ELISA) and by second-generation recombinant immunoblot assay (RIBA-2); all also had detectable serum HCV RNA. Two children had long-lasting alanine aminotransferase (ALT) elevations, and one of them became HCV RNA positive. None of the other children developed biochemical hepatitis. However, two additional children had temporary viremia. Only the child with biochemical and biopsy-proven hepatitis and detectable HCV RNA in multiple blood samples actively produced anti-HCV antibody. CONCLUSIONS: Mother-to-infant transmission of HCV infection from chronically infected women without human immunodeficiency virus (HIV) infection seems to be uncommon.},
  author       = {Wejstål, R and Widell, Anders and Månsson, Ann-Sofie and Hermodsson, S and Norkrans, G},
  issn         = {0003-4819},
  language     = {eng},
  number       = {11},
  pages        = {887--890},
  publisher    = {American College of Physicians},
  series       = {Annals of Internal Medicine},
  title        = {Mother-to-infant transmission of hepatitis C virus},
  volume       = {117},
  year         = {1992},
}