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Genetic relatedness of hepatitis A virus strains recovered from different geographical regions

Robertson, Betty H; Jansen, Robert W; Khanna, Bhawna; Totsuka, Atsuko; Nainan, Omana V; Siegl, Gunter; Widell, Anders LU ; Margolis, Harold S; Isomura, Shin and Ito, Kiichi, et al. (1992) In Journal of General Virology 73. p.1365-1377
Abstract
A pairwise comparison of the nucleic acid sequence of 168 bases from 152 wild-type or unique cell culture-adapted strains of hepatitis A virus (HAV) revealed that HAV strains can be differentiated genetically into seven unique genotypes (I to VII). In general, the nucleotide sequence of viruses in different genotypes differs at 15 to 25% of positions within this segment of the genome. Viruses from four of the genotypes (I, II, III and VII) were recovered from cases of hepatitis A in humans, whereas viruses from the other three genotypes (IV, V and VI) were isolated only from simian species developing a hepatitis A-like illness during captivity. Among non-epidemiologically related human HAV strains, 81 were characterized as genotype I, and... (More)
A pairwise comparison of the nucleic acid sequence of 168 bases from 152 wild-type or unique cell culture-adapted strains of hepatitis A virus (HAV) revealed that HAV strains can be differentiated genetically into seven unique genotypes (I to VII). In general, the nucleotide sequence of viruses in different genotypes differs at 15 to 25% of positions within this segment of the genome. Viruses from four of the genotypes (I, II, III and VII) were recovered from cases of hepatitis A in humans, whereas viruses from the other three genotypes (IV, V and VI) were isolated only from simian species developing a hepatitis A-like illness during captivity. Among non-epidemiologically related human HAV strains, 81 were characterized as genotype I, and 19 as genotype III. Within each of these major genotypes, there were two distinct groups (subgenotypes), which differed in sequence at approximately 7.5% of base positions. Each genotype and subgenotype has a characteristic amino acid sequence in this region of the polyprotein, with the most divergent genotypes differing at 10 of 56 residues. Strains recovered from some geographical regions belonged to a common (endemic) genotype, whereas strains from other regions belonged to several, probably imported, genotypes. Thus, HAV strains recovered in North America were for the most part closely related at the nucleotide sequence level, whereas in other regions, such as Japan and Western Europe, HAV strains were derived from multiple genotypes or sub-genotypes. These data indicate that patterns of endemic transmission can be differentiated from situations in which infections are imported due to travel. (Less)
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Journal of General Virology
volume
73
pages
1365 - 1377
publisher
Society for General Microbiology
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  • pmid:1318940
  • scopus:0026631017
ISSN
1465-2099
DOI
10.1099/0022-1317-73-6-1365
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English
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yes
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b0bf53b5-6189-49a3-807c-ebc646562702 (old id 1106204)
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2008-08-11 15:53:56
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@article{b0bf53b5-6189-49a3-807c-ebc646562702,
  abstract     = {A pairwise comparison of the nucleic acid sequence of 168 bases from 152 wild-type or unique cell culture-adapted strains of hepatitis A virus (HAV) revealed that HAV strains can be differentiated genetically into seven unique genotypes (I to VII). In general, the nucleotide sequence of viruses in different genotypes differs at 15 to 25% of positions within this segment of the genome. Viruses from four of the genotypes (I, II, III and VII) were recovered from cases of hepatitis A in humans, whereas viruses from the other three genotypes (IV, V and VI) were isolated only from simian species developing a hepatitis A-like illness during captivity. Among non-epidemiologically related human HAV strains, 81 were characterized as genotype I, and 19 as genotype III. Within each of these major genotypes, there were two distinct groups (subgenotypes), which differed in sequence at approximately 7.5% of base positions. Each genotype and subgenotype has a characteristic amino acid sequence in this region of the polyprotein, with the most divergent genotypes differing at 10 of 56 residues. Strains recovered from some geographical regions belonged to a common (endemic) genotype, whereas strains from other regions belonged to several, probably imported, genotypes. Thus, HAV strains recovered in North America were for the most part closely related at the nucleotide sequence level, whereas in other regions, such as Japan and Western Europe, HAV strains were derived from multiple genotypes or sub-genotypes. These data indicate that patterns of endemic transmission can be differentiated from situations in which infections are imported due to travel.},
  author       = {Robertson, Betty H and Jansen, Robert W and Khanna, Bhawna and Totsuka, Atsuko and Nainan, Omana V and Siegl, Gunter and Widell, Anders and Margolis, Harold S and Isomura, Shin and Ito, Kiichi and Ishizu, Tetsuya and Moritsugu, Yasuo and Lemon, Stanley M},
  issn         = {1465-2099},
  language     = {eng},
  pages        = {1365--1377},
  publisher    = {Society for General Microbiology},
  series       = {Journal of General Virology},
  title        = {Genetic relatedness of hepatitis A virus strains recovered from different geographical regions},
  url          = {http://dx.doi.org/10.1099/0022-1317-73-6-1365},
  volume       = {73},
  year         = {1992},
}