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Herpes simplex virus--the most frequently isolated pathogen in the lungs of patients with severe respiratory distress

Prellner, Thorbjörn LU ; Flamholc, Leo LU ; Haidl, Sven LU ; Lindholm, Karin and Widell, Anders LU (1992) In Scandinavian Journal of Infectious Diseases 24(3). p.283-292
Abstract
308 consecutive patients with severe or complicated respiratory tract infections underwent fiber-optic bronchoscopy in the search for a microbiological etiology. Protected brush specimens were used for bacterial cultures and bronchoalveolar lavage (BAL) for virus isolation and cytological examination. Herpes simplex virus (HSV) was the most commonly found pathogen and was isolated in 37 patients. 20 (54%) of them also had serological and/or cytological signs of HSV infection. 132 patients required assisted ventilation (AV) and in this group 34 (92%) of the 37 HSV positive patients were found. Isolation of HSV was significantly (p less than 0.001) associated with AV compared to patients not requiring AV. Of all patients treated with AV 26%... (More)
308 consecutive patients with severe or complicated respiratory tract infections underwent fiber-optic bronchoscopy in the search for a microbiological etiology. Protected brush specimens were used for bacterial cultures and bronchoalveolar lavage (BAL) for virus isolation and cytological examination. Herpes simplex virus (HSV) was the most commonly found pathogen and was isolated in 37 patients. 20 (54%) of them also had serological and/or cytological signs of HSV infection. 132 patients required assisted ventilation (AV) and in this group 34 (92%) of the 37 HSV positive patients were found. Isolation of HSV was significantly (p less than 0.001) associated with AV compared to patients not requiring AV. Of all patients treated with AV 26% had positive HSV isolation in conjunction with suspected acute lower respiratory infection. Coinfection with HSV and bacteria occurred in only 8 (22%) patients. HSV was more common in patients with burns (47%) compared to other patient groups such as patients with AIDS (3%) or other immunodeficiencies (9%). (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Infectious Diseases
volume
24
issue
3
pages
283 - 292
publisher
Informa Healthcare
external identifiers
  • pmid:1324521
  • scopus:0026777302
ISSN
1651-1980
DOI
10.3109/00365549209061333
language
English
LU publication?
yes
id
8dc0ecaa-0588-4b5b-8243-9be80ef4c599 (old id 1106214)
date added to LUP
2008-08-11 15:57:25
date last changed
2017-07-02 04:29:03
@article{8dc0ecaa-0588-4b5b-8243-9be80ef4c599,
  abstract     = {308 consecutive patients with severe or complicated respiratory tract infections underwent fiber-optic bronchoscopy in the search for a microbiological etiology. Protected brush specimens were used for bacterial cultures and bronchoalveolar lavage (BAL) for virus isolation and cytological examination. Herpes simplex virus (HSV) was the most commonly found pathogen and was isolated in 37 patients. 20 (54%) of them also had serological and/or cytological signs of HSV infection. 132 patients required assisted ventilation (AV) and in this group 34 (92%) of the 37 HSV positive patients were found. Isolation of HSV was significantly (p less than 0.001) associated with AV compared to patients not requiring AV. Of all patients treated with AV 26% had positive HSV isolation in conjunction with suspected acute lower respiratory infection. Coinfection with HSV and bacteria occurred in only 8 (22%) patients. HSV was more common in patients with burns (47%) compared to other patient groups such as patients with AIDS (3%) or other immunodeficiencies (9%).},
  author       = {Prellner, Thorbjörn and Flamholc, Leo and Haidl, Sven and Lindholm, Karin and Widell, Anders},
  issn         = {1651-1980},
  language     = {eng},
  number       = {3},
  pages        = {283--292},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Infectious Diseases},
  title        = {Herpes simplex virus--the most frequently isolated pathogen in the lungs of patients with severe respiratory distress},
  url          = {http://dx.doi.org/10.3109/00365549209061333},
  volume       = {24},
  year         = {1992},
}