Structural, functional and circulatory placental changes associated with impaired glucose metabolism.
(2002) In European Journal of Obstetrics, Gynecology, and Reproductive Biology 105(2). p.136-142- Abstract
- OBJECTIVE: To investigate associations between structural, functional and circulatory placental changes in pregnancies complicated by impaired glucose metabolism. DESIGN: Umbilical artery (UA) blood flow resistance was measured by Doppler velocimetry in 21 gravidae with diabetes/impaired glucose tolerance (IGT) and 10 healthy gravidae. Umbilical and placental vessel segments were incubated for determination of prostacyclin and thromboxane synthesis, and tissues histologically examined. Non-parametric statistical tests at a two-tailed P<0.05 were used. RESULTS: Placental lesions were more common in diabetes/IGT and, although not being an uniform finding, in general associated with a higher vascular synthesis of thromboxane and/or lower... (More)
- OBJECTIVE: To investigate associations between structural, functional and circulatory placental changes in pregnancies complicated by impaired glucose metabolism. DESIGN: Umbilical artery (UA) blood flow resistance was measured by Doppler velocimetry in 21 gravidae with diabetes/impaired glucose tolerance (IGT) and 10 healthy gravidae. Umbilical and placental vessel segments were incubated for determination of prostacyclin and thromboxane synthesis, and tissues histologically examined. Non-parametric statistical tests at a two-tailed P<0.05 were used. RESULTS: Placental lesions were more common in diabetes/IGT and, although not being an uniform finding, in general associated with a higher vascular synthesis of thromboxane and/or lower prostacyclin/thromboxane synthesis ratio. As an exception, ischemic villitis was associated with a higher ratio and higher UA flow resistance. CONCLUSIONS: Placental lesions are associated with an altered vascular prostanoid synthesis in diabetes/IGT, but not until structural signs of ischemia develop is a rise of UA blood flow resistance detected. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/110626
- author
- Saldeen, Pia ; Olofsson, Per LU and Laurini, Ricardo LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Obstetrics, Gynecology, and Reproductive Biology
- volume
- 105
- issue
- 2
- pages
- 136 - 142
- publisher
- Elsevier
- external identifiers
-
- wos:000179086200006
- pmid:12381475
- scopus:0037110876
- ISSN
- 0301-2115
- DOI
- 10.1016/S0301-2115(02)00161-6
- language
- English
- LU publication?
- yes
- id
- 46cfa07c-87c5-4e2b-8cc4-79041df5fd6d (old id 110626)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12381475&dopt=Abstract
- date added to LUP
- 2016-04-01 11:36:43
- date last changed
- 2022-01-26 07:37:30
@article{46cfa07c-87c5-4e2b-8cc4-79041df5fd6d, abstract = {{OBJECTIVE: To investigate associations between structural, functional and circulatory placental changes in pregnancies complicated by impaired glucose metabolism. DESIGN: Umbilical artery (UA) blood flow resistance was measured by Doppler velocimetry in 21 gravidae with diabetes/impaired glucose tolerance (IGT) and 10 healthy gravidae. Umbilical and placental vessel segments were incubated for determination of prostacyclin and thromboxane synthesis, and tissues histologically examined. Non-parametric statistical tests at a two-tailed P<0.05 were used. RESULTS: Placental lesions were more common in diabetes/IGT and, although not being an uniform finding, in general associated with a higher vascular synthesis of thromboxane and/or lower prostacyclin/thromboxane synthesis ratio. As an exception, ischemic villitis was associated with a higher ratio and higher UA flow resistance. CONCLUSIONS: Placental lesions are associated with an altered vascular prostanoid synthesis in diabetes/IGT, but not until structural signs of ischemia develop is a rise of UA blood flow resistance detected.}}, author = {{Saldeen, Pia and Olofsson, Per and Laurini, Ricardo}}, issn = {{0301-2115}}, language = {{eng}}, number = {{2}}, pages = {{136--142}}, publisher = {{Elsevier}}, series = {{European Journal of Obstetrics, Gynecology, and Reproductive Biology}}, title = {{Structural, functional and circulatory placental changes associated with impaired glucose metabolism.}}, url = {{http://dx.doi.org/10.1016/S0301-2115(02)00161-6}}, doi = {{10.1016/S0301-2115(02)00161-6}}, volume = {{105}}, year = {{2002}}, }