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Structural, functional and circulatory placental changes associated with impaired glucose metabolism.

Saldeen, Pia; Olofsson, Per LU and Laurini, Ricardo LU (2002) In European Journal of Obstetrics, Gynecology, and Reproductive Biology 105(2). p.136-142
Abstract
OBJECTIVE: To investigate associations between structural, functional and circulatory placental changes in pregnancies complicated by impaired glucose metabolism. DESIGN: Umbilical artery (UA) blood flow resistance was measured by Doppler velocimetry in 21 gravidae with diabetes/impaired glucose tolerance (IGT) and 10 healthy gravidae. Umbilical and placental vessel segments were incubated for determination of prostacyclin and thromboxane synthesis, and tissues histologically examined. Non-parametric statistical tests at a two-tailed P<0.05 were used. RESULTS: Placental lesions were more common in diabetes/IGT and, although not being an uniform finding, in general associated with a higher vascular synthesis of thromboxane and/or lower... (More)
OBJECTIVE: To investigate associations between structural, functional and circulatory placental changes in pregnancies complicated by impaired glucose metabolism. DESIGN: Umbilical artery (UA) blood flow resistance was measured by Doppler velocimetry in 21 gravidae with diabetes/impaired glucose tolerance (IGT) and 10 healthy gravidae. Umbilical and placental vessel segments were incubated for determination of prostacyclin and thromboxane synthesis, and tissues histologically examined. Non-parametric statistical tests at a two-tailed P<0.05 were used. RESULTS: Placental lesions were more common in diabetes/IGT and, although not being an uniform finding, in general associated with a higher vascular synthesis of thromboxane and/or lower prostacyclin/thromboxane synthesis ratio. As an exception, ischemic villitis was associated with a higher ratio and higher UA flow resistance. CONCLUSIONS: Placental lesions are associated with an altered vascular prostanoid synthesis in diabetes/IGT, but not until structural signs of ischemia develop is a rise of UA blood flow resistance detected. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
European Journal of Obstetrics, Gynecology, and Reproductive Biology
volume
105
issue
2
pages
136 - 142
publisher
Elsevier
external identifiers
  • wos:000179086200006
  • pmid:12381475
  • scopus:0037110876
ISSN
0301-2115
DOI
10.1016/S0301-2115(02)00161-6
language
English
LU publication?
yes
id
46cfa07c-87c5-4e2b-8cc4-79041df5fd6d (old id 110626)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12381475&dopt=Abstract
date added to LUP
2007-07-30 15:39:08
date last changed
2017-01-01 04:22:12
@article{46cfa07c-87c5-4e2b-8cc4-79041df5fd6d,
  abstract     = {OBJECTIVE: To investigate associations between structural, functional and circulatory placental changes in pregnancies complicated by impaired glucose metabolism. DESIGN: Umbilical artery (UA) blood flow resistance was measured by Doppler velocimetry in 21 gravidae with diabetes/impaired glucose tolerance (IGT) and 10 healthy gravidae. Umbilical and placental vessel segments were incubated for determination of prostacyclin and thromboxane synthesis, and tissues histologically examined. Non-parametric statistical tests at a two-tailed P&lt;0.05 were used. RESULTS: Placental lesions were more common in diabetes/IGT and, although not being an uniform finding, in general associated with a higher vascular synthesis of thromboxane and/or lower prostacyclin/thromboxane synthesis ratio. As an exception, ischemic villitis was associated with a higher ratio and higher UA flow resistance. CONCLUSIONS: Placental lesions are associated with an altered vascular prostanoid synthesis in diabetes/IGT, but not until structural signs of ischemia develop is a rise of UA blood flow resistance detected.},
  author       = {Saldeen, Pia and Olofsson, Per and Laurini, Ricardo},
  issn         = {0301-2115},
  language     = {eng},
  number       = {2},
  pages        = {136--142},
  publisher    = {Elsevier},
  series       = {European Journal of Obstetrics, Gynecology, and Reproductive Biology},
  title        = {Structural, functional and circulatory placental changes associated with impaired glucose metabolism.},
  url          = {http://dx.doi.org/10.1016/S0301-2115(02)00161-6},
  volume       = {105},
  year         = {2002},
}