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Flow cytometry DNA analysis and prediction of loco-regional recurrences after mastectomy in breast cancer

Ewers, Sven-Börje LU ; Attewell, Robyn; Baldetorp, Bo LU ; Borg, Åke LU ; Fernö, Mårten LU ; Långström-Einarsson, Eva LU ; Ryden, Stefan and Killander, Dick LU (1992) In Acta Oncologica 31(7). p.733-740
Abstract
The study concerns whether DNA flow cytometry and estrogen receptor analysis might help predict which breast cancer patients, particularly node-positive ones, were at the greatest risk of developing loco-regional recurrence (LRR). Such patients would best benefit from postoperative radiotherapy following modified radical mastectomy and axillary lymph node dissection. After this type of surgery, 506 patients were followed up for a median time of nearly 5 years. Among the 235 patients given postoperative radiotherapy, the loco-regional control rate was 100% in N0 cases (n = 93), 94% in cases with 1-3 positive nodes (n = 90), 93% in cases with 4-9 positive nodes (n = 43), and 67% in cases with 10 or more positive nodes (n = 9). Among the 271... (More)
The study concerns whether DNA flow cytometry and estrogen receptor analysis might help predict which breast cancer patients, particularly node-positive ones, were at the greatest risk of developing loco-regional recurrence (LRR). Such patients would best benefit from postoperative radiotherapy following modified radical mastectomy and axillary lymph node dissection. After this type of surgery, 506 patients were followed up for a median time of nearly 5 years. Among the 235 patients given postoperative radiotherapy, the loco-regional control rate was 100% in N0 cases (n = 93), 94% in cases with 1-3 positive nodes (n = 90), 93% in cases with 4-9 positive nodes (n = 43), and 67% in cases with 10 or more positive nodes (n = 9). Among the 271 non-irradiated patients, the corresponding figures for loco-regional control were 91% in N0 cases (n = 141), 71% in cases with 1-3 positive nodes (n = 84), 65% in cases with 4-9 positive nodes (n = 31), and 67% in cases with 10 or more positive nodes (n = 15). Ploidy status, level of S-phase fraction, estrogen receptor content, and primary tumor size did not, in the present material, yield significant additional information with regard to the risk of LRR in the different nodal subgroups, a finding confirmed in multivariate analysis where the only significant predictor of LRR was the number of positive nodes (p = 0.01). Adjuvant tamoxifen treatment could not replace postoperative radiotherapy for achieving loco-regional tumor control, the overall rate of which was 81% among patients treated with tamoxifen only (n = 117), as compared with 98% among those also treated with radiotherapy (n = 54) (p = 0.003). (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oncologica
volume
31
issue
7
pages
733 - 740
publisher
Taylor & Francis
external identifiers
  • pmid:1476753
  • scopus:0027058360
ISSN
1651-226X
DOI
10.3109/02841869209083862
language
English
LU publication?
yes
id
ca7f66e2-350b-47fd-bce0-25ab3882edb2 (old id 1106314)
date added to LUP
2008-08-01 14:05:49
date last changed
2017-01-01 06:43:12
@article{ca7f66e2-350b-47fd-bce0-25ab3882edb2,
  abstract     = {The study concerns whether DNA flow cytometry and estrogen receptor analysis might help predict which breast cancer patients, particularly node-positive ones, were at the greatest risk of developing loco-regional recurrence (LRR). Such patients would best benefit from postoperative radiotherapy following modified radical mastectomy and axillary lymph node dissection. After this type of surgery, 506 patients were followed up for a median time of nearly 5 years. Among the 235 patients given postoperative radiotherapy, the loco-regional control rate was 100% in N0 cases (n = 93), 94% in cases with 1-3 positive nodes (n = 90), 93% in cases with 4-9 positive nodes (n = 43), and 67% in cases with 10 or more positive nodes (n = 9). Among the 271 non-irradiated patients, the corresponding figures for loco-regional control were 91% in N0 cases (n = 141), 71% in cases with 1-3 positive nodes (n = 84), 65% in cases with 4-9 positive nodes (n = 31), and 67% in cases with 10 or more positive nodes (n = 15). Ploidy status, level of S-phase fraction, estrogen receptor content, and primary tumor size did not, in the present material, yield significant additional information with regard to the risk of LRR in the different nodal subgroups, a finding confirmed in multivariate analysis where the only significant predictor of LRR was the number of positive nodes (p = 0.01). Adjuvant tamoxifen treatment could not replace postoperative radiotherapy for achieving loco-regional tumor control, the overall rate of which was 81% among patients treated with tamoxifen only (n = 117), as compared with 98% among those also treated with radiotherapy (n = 54) (p = 0.003).},
  author       = {Ewers, Sven-Börje and Attewell, Robyn and Baldetorp, Bo and Borg, Åke and Fernö, Mårten and Långström-Einarsson, Eva and Ryden, Stefan and Killander, Dick},
  issn         = {1651-226X},
  language     = {eng},
  number       = {7},
  pages        = {733--740},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Flow cytometry DNA analysis and prediction of loco-regional recurrences after mastectomy in breast cancer},
  url          = {http://dx.doi.org/10.3109/02841869209083862},
  volume       = {31},
  year         = {1992},
}