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Heterogeneity of contractile 5-HT receptors in human hand veins

Bodelsson, Mikael LU ; Törnebrandt, Kenneth; Bertilsson, Inga-Lill LU and Arneklo-Nobin, Birgitta (1992) In European Journal of Pharmacology 219(3-4). p.455-460
Abstract
To increase our knowledge of human peripheral vasospasm we characterized the contractile 5-hydroxytryptamine (5-HT) receptors in human superficial hand vein segments in vitro. The 5-HT1 receptor agonist, sumatriptan, the 5-HT2 receptor agonist, dl-alpha-methyl-5-HT, and the 5-HT3 receptor agonist, 2-methyl-5-HT, all induced concentration-dependent contractions. The contractile response to sumatriptan was antagonized by the non-selective 5-HT receptor antagonist, methiothepin, but was unaffected by the 5-HT2 receptor antagonist, ketanserin. The contractile response to dl-alpha-methyl-5-HT was antagonized by both methiothepin and ketanserin. The contraction elicited by 2-methyl-5-HT was not affected by the 5-HT3 receptor antagonist, MDL... (More)
To increase our knowledge of human peripheral vasospasm we characterized the contractile 5-hydroxytryptamine (5-HT) receptors in human superficial hand vein segments in vitro. The 5-HT1 receptor agonist, sumatriptan, the 5-HT2 receptor agonist, dl-alpha-methyl-5-HT, and the 5-HT3 receptor agonist, 2-methyl-5-HT, all induced concentration-dependent contractions. The contractile response to sumatriptan was antagonized by the non-selective 5-HT receptor antagonist, methiothepin, but was unaffected by the 5-HT2 receptor antagonist, ketanserin. The contractile response to dl-alpha-methyl-5-HT was antagonized by both methiothepin and ketanserin. The contraction elicited by 2-methyl-5-HT was not affected by the 5-HT3 receptor antagonist, MDL 72222, but was antagonized by ketanserin. The results suggest that serotonergic contraction in the human superficial hand vein involves both 5-HT1 and 5-HT2 but not 5-HT3 receptors. Such receptor heterogeneity in human blood vessels should be considered when using drugs and when designing future compounds for medical use. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Vein, serotonin), 5-HT receptors, 5-HT (5-hydroxytryptamine, Hand (human), Smooth muscle
in
European Journal of Pharmacology
volume
219
issue
3-4
pages
455 - 460
publisher
Elsevier
external identifiers
  • pmid:1425972
  • scopus:0026784754
ISSN
1879-0712
DOI
10.1016/0014-2999(92)90488-P
language
English
LU publication?
yes
id
e69402d9-f04f-4c20-a3ba-5c67c28d9bc2 (old id 1106387)
date added to LUP
2008-07-31 10:46:19
date last changed
2017-01-01 04:34:55
@article{e69402d9-f04f-4c20-a3ba-5c67c28d9bc2,
  abstract     = {To increase our knowledge of human peripheral vasospasm we characterized the contractile 5-hydroxytryptamine (5-HT) receptors in human superficial hand vein segments in vitro. The 5-HT1 receptor agonist, sumatriptan, the 5-HT2 receptor agonist, dl-alpha-methyl-5-HT, and the 5-HT3 receptor agonist, 2-methyl-5-HT, all induced concentration-dependent contractions. The contractile response to sumatriptan was antagonized by the non-selective 5-HT receptor antagonist, methiothepin, but was unaffected by the 5-HT2 receptor antagonist, ketanserin. The contractile response to dl-alpha-methyl-5-HT was antagonized by both methiothepin and ketanserin. The contraction elicited by 2-methyl-5-HT was not affected by the 5-HT3 receptor antagonist, MDL 72222, but was antagonized by ketanserin. The results suggest that serotonergic contraction in the human superficial hand vein involves both 5-HT1 and 5-HT2 but not 5-HT3 receptors. Such receptor heterogeneity in human blood vessels should be considered when using drugs and when designing future compounds for medical use.},
  author       = {Bodelsson, Mikael and Törnebrandt, Kenneth and Bertilsson, Inga-Lill and Arneklo-Nobin, Birgitta},
  issn         = {1879-0712},
  keyword      = {Vein,serotonin),5-HT receptors,5-HT (5-hydroxytryptamine,Hand (human),Smooth muscle},
  language     = {eng},
  number       = {3-4},
  pages        = {455--460},
  publisher    = {Elsevier},
  series       = {European Journal of Pharmacology},
  title        = {Heterogeneity of contractile 5-HT receptors in human hand veins},
  url          = {http://dx.doi.org/10.1016/0014-2999(92)90488-P},
  volume       = {219},
  year         = {1992},
}