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Heterogeneity of contractile 5-HT receptors in human hand veins

Bodelsson, Mikael LU ; Törnebrandt, Kenneth ; Bertilsson, Inga-Lill LU and Arneklo-Nobin, Birgitta (1992) In European Journal of Pharmacology 219(3-4). p.455-460
Abstract
To increase our knowledge of human peripheral vasospasm we characterized the contractile 5-hydroxytryptamine (5-HT) receptors in human superficial hand vein segments in vitro. The 5-HT1 receptor agonist, sumatriptan, the 5-HT2 receptor agonist, dl-alpha-methyl-5-HT, and the 5-HT3 receptor agonist, 2-methyl-5-HT, all induced concentration-dependent contractions. The contractile response to sumatriptan was antagonized by the non-selective 5-HT receptor antagonist, methiothepin, but was unaffected by the 5-HT2 receptor antagonist, ketanserin. The contractile response to dl-alpha-methyl-5-HT was antagonized by both methiothepin and ketanserin. The contraction elicited by 2-methyl-5-HT was not affected by the 5-HT3 receptor antagonist, MDL... (More)
To increase our knowledge of human peripheral vasospasm we characterized the contractile 5-hydroxytryptamine (5-HT) receptors in human superficial hand vein segments in vitro. The 5-HT1 receptor agonist, sumatriptan, the 5-HT2 receptor agonist, dl-alpha-methyl-5-HT, and the 5-HT3 receptor agonist, 2-methyl-5-HT, all induced concentration-dependent contractions. The contractile response to sumatriptan was antagonized by the non-selective 5-HT receptor antagonist, methiothepin, but was unaffected by the 5-HT2 receptor antagonist, ketanserin. The contractile response to dl-alpha-methyl-5-HT was antagonized by both methiothepin and ketanserin. The contraction elicited by 2-methyl-5-HT was not affected by the 5-HT3 receptor antagonist, MDL 72222, but was antagonized by ketanserin. The results suggest that serotonergic contraction in the human superficial hand vein involves both 5-HT1 and 5-HT2 but not 5-HT3 receptors. Such receptor heterogeneity in human blood vessels should be considered when using drugs and when designing future compounds for medical use. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Vein, serotonin), 5-HT receptors, 5-HT (5-hydroxytryptamine, Hand (human), Smooth muscle
in
European Journal of Pharmacology
volume
219
issue
3-4
pages
455 - 460
publisher
Elsevier
external identifiers
  • pmid:1425972
  • scopus:0026784754
ISSN
1879-0712
DOI
10.1016/0014-2999(92)90488-P
language
English
LU publication?
yes
id
e69402d9-f04f-4c20-a3ba-5c67c28d9bc2 (old id 1106387)
date added to LUP
2016-04-01 11:49:43
date last changed
2021-01-03 09:34:46
@article{e69402d9-f04f-4c20-a3ba-5c67c28d9bc2,
  abstract     = {{To increase our knowledge of human peripheral vasospasm we characterized the contractile 5-hydroxytryptamine (5-HT) receptors in human superficial hand vein segments in vitro. The 5-HT1 receptor agonist, sumatriptan, the 5-HT2 receptor agonist, dl-alpha-methyl-5-HT, and the 5-HT3 receptor agonist, 2-methyl-5-HT, all induced concentration-dependent contractions. The contractile response to sumatriptan was antagonized by the non-selective 5-HT receptor antagonist, methiothepin, but was unaffected by the 5-HT2 receptor antagonist, ketanserin. The contractile response to dl-alpha-methyl-5-HT was antagonized by both methiothepin and ketanserin. The contraction elicited by 2-methyl-5-HT was not affected by the 5-HT3 receptor antagonist, MDL 72222, but was antagonized by ketanserin. The results suggest that serotonergic contraction in the human superficial hand vein involves both 5-HT1 and 5-HT2 but not 5-HT3 receptors. Such receptor heterogeneity in human blood vessels should be considered when using drugs and when designing future compounds for medical use.}},
  author       = {{Bodelsson, Mikael and Törnebrandt, Kenneth and Bertilsson, Inga-Lill and Arneklo-Nobin, Birgitta}},
  issn         = {{1879-0712}},
  keywords     = {{Vein; serotonin); 5-HT receptors; 5-HT (5-hydroxytryptamine; Hand (human); Smooth muscle}},
  language     = {{eng}},
  number       = {{3-4}},
  pages        = {{455--460}},
  publisher    = {{Elsevier}},
  series       = {{European Journal of Pharmacology}},
  title        = {{Heterogeneity of contractile 5-HT receptors in human hand veins}},
  url          = {{http://dx.doi.org/10.1016/0014-2999(92)90488-P}},
  doi          = {{10.1016/0014-2999(92)90488-P}},
  volume       = {{219}},
  year         = {{1992}},
}