Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Immunohistochemical study of 158 lung carcinomas

Johansson, L ; Andersson, C and Albin, Maria LU (1992) In APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 100(10). p.914-921
Abstract
Lung carcinomas were studied immunohistochemically and the results were related to type of tissue sample (bronchoscopic biopsies, surgical specimens, autopsies). All cytokeratins (CAM 5.2, PKK-1, AE1/AE3) reacted with virtually all adenocarcinomas, most squamous, and 65% of the large cell carcinomas, while CAM 5.2 was most efficient with the small cell carcinomas. CEA stained 33% and 60% of the small and large cell carcinomas, respectively, most adenocarcinomas, and 84% of the squamous cell carcinomas, among which staining decreased with dedifferentiation and was often focal. EMA reacted with 90%, and NSE with 20% of all histological types. There was no staining for NF. All antibodies, except EMA, were more efficient with surgical... (More)
Lung carcinomas were studied immunohistochemically and the results were related to type of tissue sample (bronchoscopic biopsies, surgical specimens, autopsies). All cytokeratins (CAM 5.2, PKK-1, AE1/AE3) reacted with virtually all adenocarcinomas, most squamous, and 65% of the large cell carcinomas, while CAM 5.2 was most efficient with the small cell carcinomas. CEA stained 33% and 60% of the small and large cell carcinomas, respectively, most adenocarcinomas, and 84% of the squamous cell carcinomas, among which staining decreased with dedifferentiation and was often focal. EMA reacted with 90%, and NSE with 20% of all histological types. There was no staining for NF. All antibodies, except EMA, were more efficient with surgical specimens. Our study implies that the cytokeratins we used work better with surgical material, but are generally comparable to monospecific cytokeratin antibodies. Also, EMA is a reliable marker for epithelial differentiation with all types of tissue samples. Moreover, CEA negativity in several poorly differentiated lung carcinomas might have implications in the differential diagnosis against pleural mesothelioma. (Less)
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
volume
100
issue
10
pages
914 - 921
publisher
Blackwell Munksgaard
external identifiers
  • pmid:1280149
  • scopus:0026486154
ISSN
1600-0463
language
English
LU publication?
yes
id
cf0dde2a-1de1-4aeb-9f7b-5f410161f5f1 (old id 1106418)
date added to LUP
2016-04-01 11:57:05
date last changed
2025-01-02 00:00:11
@article{cf0dde2a-1de1-4aeb-9f7b-5f410161f5f1,
  abstract     = {{Lung carcinomas were studied immunohistochemically and the results were related to type of tissue sample (bronchoscopic biopsies, surgical specimens, autopsies). All cytokeratins (CAM 5.2, PKK-1, AE1/AE3) reacted with virtually all adenocarcinomas, most squamous, and 65% of the large cell carcinomas, while CAM 5.2 was most efficient with the small cell carcinomas. CEA stained 33% and 60% of the small and large cell carcinomas, respectively, most adenocarcinomas, and 84% of the squamous cell carcinomas, among which staining decreased with dedifferentiation and was often focal. EMA reacted with 90%, and NSE with 20% of all histological types. There was no staining for NF. All antibodies, except EMA, were more efficient with surgical specimens. Our study implies that the cytokeratins we used work better with surgical material, but are generally comparable to monospecific cytokeratin antibodies. Also, EMA is a reliable marker for epithelial differentiation with all types of tissue samples. Moreover, CEA negativity in several poorly differentiated lung carcinomas might have implications in the differential diagnosis against pleural mesothelioma.}},
  author       = {{Johansson, L and Andersson, C and Albin, Maria}},
  issn         = {{1600-0463}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{914--921}},
  publisher    = {{Blackwell Munksgaard}},
  series       = {{APMIS : acta pathologica, microbiologica, et immunologica Scandinavica}},
  title        = {{Immunohistochemical study of 158 lung carcinomas}},
  volume       = {{100}},
  year         = {{1992}},
}