Effect on primary haemostasis of prophylactic regimens of low molecular weight heparin, unfractionated heparin, dextran and their combinations. An animal experimental study
(1992) In Thrombosis Research 65(4-5). p.651-656- Abstract
- The aim of the study was to determine whether an impairment of the haemostasis could be observed experimentally when thromboprophylactic substances, which act differently on the haemostatic mechanism, were given single or in combination in prophylactic doses. In 36 rabbits we measured the primary haemostatic plug formation time (PHT), rebleedings and total haemostatic plug formation time (THT) after transection of venules and arterioles using an intravital microscope. We combined unfractionated heparin (UH) and low molecular weight heparin (LMWH) in low dose with either dextran 70 or polygeline (placebo volume expander) in a randomized double-dummy set up. In the placebo group (NaCl and polygeline) the median PHT was 55 and 101 seconds for... (More)
- The aim of the study was to determine whether an impairment of the haemostasis could be observed experimentally when thromboprophylactic substances, which act differently on the haemostatic mechanism, were given single or in combination in prophylactic doses. In 36 rabbits we measured the primary haemostatic plug formation time (PHT), rebleedings and total haemostatic plug formation time (THT) after transection of venules and arterioles using an intravital microscope. We combined unfractionated heparin (UH) and low molecular weight heparin (LMWH) in low dose with either dextran 70 or polygeline (placebo volume expander) in a randomized double-dummy set up. In the placebo group (NaCl and polygeline) the median PHT was 55 and 101 seconds for arterioles and venules respectively, which are well-comparable to earlier results from our group. Most prolonged PHT and THT for arterioles were seen for dextran+NaCl, actually less prolongation was seen for UH+dextran. We did not observe any differences, except for a prolongation of THT for venules in rabbits given dextran+NaCl (p less than 0.05). Thus, in thromboprophylactic doses used, there does not seem to be an impaired or additive effect between heparins and dextran 70 in primary haemostasis in rabbits. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1106561
- author
- Holst, Jan LU ; Lindblad, Bengt LU ; Mätzsch, Thomas LU and Bergqvist, David
- organization
- publishing date
- 1992
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Author Keywords: haemostasis, thromboprophylaxis, low dose heparin, low molecular weight heparin, dextran
- in
- Thrombosis Research
- volume
- 65
- issue
- 4-5
- pages
- 651 - 656
- publisher
- Elsevier
- external identifiers
-
- pmid:1377419
- scopus:0026521039
- ISSN
- 1879-2472
- DOI
- 10.1016/0049-3848(92)90214-U
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Unit for Clinical Vascular Disease Research (013242410), Emergency medicine/Medicine/Surgery (013240200)
- id
- 5816c361-4e75-4068-ad96-efe8079f3b77 (old id 1106561)
- date added to LUP
- 2016-04-01 12:03:34
- date last changed
- 2021-09-19 04:22:44
@article{5816c361-4e75-4068-ad96-efe8079f3b77, abstract = {{The aim of the study was to determine whether an impairment of the haemostasis could be observed experimentally when thromboprophylactic substances, which act differently on the haemostatic mechanism, were given single or in combination in prophylactic doses. In 36 rabbits we measured the primary haemostatic plug formation time (PHT), rebleedings and total haemostatic plug formation time (THT) after transection of venules and arterioles using an intravital microscope. We combined unfractionated heparin (UH) and low molecular weight heparin (LMWH) in low dose with either dextran 70 or polygeline (placebo volume expander) in a randomized double-dummy set up. In the placebo group (NaCl and polygeline) the median PHT was 55 and 101 seconds for arterioles and venules respectively, which are well-comparable to earlier results from our group. Most prolonged PHT and THT for arterioles were seen for dextran+NaCl, actually less prolongation was seen for UH+dextran. We did not observe any differences, except for a prolongation of THT for venules in rabbits given dextran+NaCl (p less than 0.05). Thus, in thromboprophylactic doses used, there does not seem to be an impaired or additive effect between heparins and dextran 70 in primary haemostasis in rabbits.}}, author = {{Holst, Jan and Lindblad, Bengt and Mätzsch, Thomas and Bergqvist, David}}, issn = {{1879-2472}}, keywords = {{Author Keywords: haemostasis; thromboprophylaxis; low dose heparin; low molecular weight heparin; dextran}}, language = {{eng}}, number = {{4-5}}, pages = {{651--656}}, publisher = {{Elsevier}}, series = {{Thrombosis Research}}, title = {{Effect on primary haemostasis of prophylactic regimens of low molecular weight heparin, unfractionated heparin, dextran and their combinations. An animal experimental study}}, url = {{http://dx.doi.org/10.1016/0049-3848(92)90214-U}}, doi = {{10.1016/0049-3848(92)90214-U}}, volume = {{65}}, year = {{1992}}, }