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Effect on primary haemostasis of prophylactic regimens of low molecular weight heparin, unfractionated heparin, dextran and their combinations. An animal experimental study

Holst, Jan LU ; Lindblad, Bengt LU ; Mätzsch, Thomas LU and Bergqvist, David (1992) In Thrombosis Research 65(4-5). p.651-656
Abstract
The aim of the study was to determine whether an impairment of the haemostasis could be observed experimentally when thromboprophylactic substances, which act differently on the haemostatic mechanism, were given single or in combination in prophylactic doses. In 36 rabbits we measured the primary haemostatic plug formation time (PHT), rebleedings and total haemostatic plug formation time (THT) after transection of venules and arterioles using an intravital microscope. We combined unfractionated heparin (UH) and low molecular weight heparin (LMWH) in low dose with either dextran 70 or polygeline (placebo volume expander) in a randomized double-dummy set up. In the placebo group (NaCl and polygeline) the median PHT was 55 and 101 seconds for... (More)
The aim of the study was to determine whether an impairment of the haemostasis could be observed experimentally when thromboprophylactic substances, which act differently on the haemostatic mechanism, were given single or in combination in prophylactic doses. In 36 rabbits we measured the primary haemostatic plug formation time (PHT), rebleedings and total haemostatic plug formation time (THT) after transection of venules and arterioles using an intravital microscope. We combined unfractionated heparin (UH) and low molecular weight heparin (LMWH) in low dose with either dextran 70 or polygeline (placebo volume expander) in a randomized double-dummy set up. In the placebo group (NaCl and polygeline) the median PHT was 55 and 101 seconds for arterioles and venules respectively, which are well-comparable to earlier results from our group. Most prolonged PHT and THT for arterioles were seen for dextran+NaCl, actually less prolongation was seen for UH+dextran. We did not observe any differences, except for a prolongation of THT for venules in rabbits given dextran+NaCl (p less than 0.05). Thus, in thromboprophylactic doses used, there does not seem to be an impaired or additive effect between heparins and dextran 70 in primary haemostasis in rabbits. (Less)
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Contribution to journal
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published
subject
keywords
Author Keywords: haemostasis, thromboprophylaxis, low dose heparin, low molecular weight heparin, dextran
in
Thrombosis Research
volume
65
issue
4-5
pages
651 - 656
publisher
Elsevier
external identifiers
  • pmid:1377419
  • scopus:0026521039
ISSN
1879-2472
DOI
10.1016/0049-3848(92)90214-U
language
English
LU publication?
yes
id
5816c361-4e75-4068-ad96-efe8079f3b77 (old id 1106561)
date added to LUP
2008-08-01 16:23:39
date last changed
2017-01-01 04:47:51
@article{5816c361-4e75-4068-ad96-efe8079f3b77,
  abstract     = {The aim of the study was to determine whether an impairment of the haemostasis could be observed experimentally when thromboprophylactic substances, which act differently on the haemostatic mechanism, were given single or in combination in prophylactic doses. In 36 rabbits we measured the primary haemostatic plug formation time (PHT), rebleedings and total haemostatic plug formation time (THT) after transection of venules and arterioles using an intravital microscope. We combined unfractionated heparin (UH) and low molecular weight heparin (LMWH) in low dose with either dextran 70 or polygeline (placebo volume expander) in a randomized double-dummy set up. In the placebo group (NaCl and polygeline) the median PHT was 55 and 101 seconds for arterioles and venules respectively, which are well-comparable to earlier results from our group. Most prolonged PHT and THT for arterioles were seen for dextran+NaCl, actually less prolongation was seen for UH+dextran. We did not observe any differences, except for a prolongation of THT for venules in rabbits given dextran+NaCl (p less than 0.05). Thus, in thromboprophylactic doses used, there does not seem to be an impaired or additive effect between heparins and dextran 70 in primary haemostasis in rabbits.},
  author       = {Holst, Jan and Lindblad, Bengt and Mätzsch, Thomas and Bergqvist, David},
  issn         = {1879-2472},
  keyword      = {Author Keywords: haemostasis,thromboprophylaxis,low dose heparin,low molecular weight heparin,dextran},
  language     = {eng},
  number       = {4-5},
  pages        = {651--656},
  publisher    = {Elsevier},
  series       = {Thrombosis Research},
  title        = {Effect on primary haemostasis of prophylactic regimens of low molecular weight heparin, unfractionated heparin, dextran and their combinations. An animal experimental study},
  url          = {http://dx.doi.org/10.1016/0049-3848(92)90214-U},
  volume       = {65},
  year         = {1992},
}