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Growth hormone levels in the basal state and after thyrotropin-releasing hormone stimulation in young type 1 (insulin-dependent) diabetic patients with severe retinopathy

Agardh, Carl-David LU ; Agardh, Elisabet LU ; Eckert, B and Sjöberg, U (1992) In Diabetes Research (Edinburgh, Scotland) 19(2). p.81-85
Abstract
Sixteen young patients with type 1 diabetes mellitus and rapidly progressive severe retinopathy were examined regarding serum levels of growth hormone before and after the i.v. administration of 200 micrograms thyrotropin-releasing hormone (TRH). Serum IGF I, HbA1c, blood pressure, urinary albumin, and serum creatinine levels were also measured. The control group consisted of type 1 diabetic patients matched for age, duration of diabetes and metabolic control with no or minimal background retinopathy. The results show that basal growth hormone levels were above normal in both groups, and that there was a paradoxical increment in growth hormone levels after TRH stimulation (p < 0.05) in patients with severe retinopathy, but the values... (More)
Sixteen young patients with type 1 diabetes mellitus and rapidly progressive severe retinopathy were examined regarding serum levels of growth hormone before and after the i.v. administration of 200 micrograms thyrotropin-releasing hormone (TRH). Serum IGF I, HbA1c, blood pressure, urinary albumin, and serum creatinine levels were also measured. The control group consisted of type 1 diabetic patients matched for age, duration of diabetes and metabolic control with no or minimal background retinopathy. The results show that basal growth hormone levels were above normal in both groups, and that there was a paradoxical increment in growth hormone levels after TRH stimulation (p < 0.05) in patients with severe retinopathy, but the values did not differ from patients with background retinopathy. IGD I levels were normal in all patients but one, and no differences were seen between the two groups. HbA1c, serum creatine, blood pressure, and urinary albumin levels were similar in the groups but patients with severe retinopathy were treated with more insulin (p < 0.001). Thus, neither abnormal growth hormone levels, nor IGF I, seems to be associated with the development of severe retinopathy in young type 1 diabetic patients. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Research (Edinburgh, Scotland)
volume
19
issue
2
pages
81 - 85
publisher
Teviot-Kimpton
external identifiers
  • pmid:1286543
  • scopus:0026817211
ISSN
0265-5985
language
English
LU publication?
yes
id
a01d000a-7a90-4240-aded-11d13170ea59 (old id 1106589)
date added to LUP
2008-07-30 10:52:16
date last changed
2017-01-01 07:02:56
@article{a01d000a-7a90-4240-aded-11d13170ea59,
  abstract     = {Sixteen young patients with type 1 diabetes mellitus and rapidly progressive severe retinopathy were examined regarding serum levels of growth hormone before and after the i.v. administration of 200 micrograms thyrotropin-releasing hormone (TRH). Serum IGF I, HbA1c, blood pressure, urinary albumin, and serum creatinine levels were also measured. The control group consisted of type 1 diabetic patients matched for age, duration of diabetes and metabolic control with no or minimal background retinopathy. The results show that basal growth hormone levels were above normal in both groups, and that there was a paradoxical increment in growth hormone levels after TRH stimulation (p &lt; 0.05) in patients with severe retinopathy, but the values did not differ from patients with background retinopathy. IGD I levels were normal in all patients but one, and no differences were seen between the two groups. HbA1c, serum creatine, blood pressure, and urinary albumin levels were similar in the groups but patients with severe retinopathy were treated with more insulin (p &lt; 0.001). Thus, neither abnormal growth hormone levels, nor IGF I, seems to be associated with the development of severe retinopathy in young type 1 diabetic patients.},
  author       = {Agardh, Carl-David and Agardh, Elisabet and Eckert, B and Sjöberg, U},
  issn         = {0265-5985},
  language     = {eng},
  number       = {2},
  pages        = {81--85},
  publisher    = {Teviot-Kimpton},
  series       = {Diabetes Research (Edinburgh, Scotland)},
  title        = {Growth hormone levels in the basal state and after thyrotropin-releasing hormone stimulation in young type 1 (insulin-dependent) diabetic patients with severe retinopathy},
  volume       = {19},
  year         = {1992},
}