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The response of regulatory peptides to moderate hypoglycaemia of short duration in type 1 (insulin-dependent) diabetes mellitus and in normal man

Tallroth, G; Ryding, Erik LU ; Ekman, R and Agardh, Carl-David LU (1992) In Diabetes Research (Edinburgh, Scotland) 20(3). p.73-85
Abstract
The changes in plasma gastrin-releasing peptide (GRP), arginine vasopressin (AVP), neuropeptide Y (NPY), corticotropin releasing hormone (CRH), galanin, ACTH, cortisol, delta sleep-inducing peptide (DSIP), adrenaline, noradrenaline and pancreatic polypeptide (PP) were measured after 5 and 15 minutes of acute insulin-induced moderate hypoglycaemia (2.0 mmol/l) in 10 patients with Type 1 diabetes mellitus with no autonomic neuropathy and in 10 healthy subjects. Plasma catecholamine and PP levels rose in both groups in response to hypoglycemia and the secretory response of ACTH was lower in the diabetic subjects (p < 0.01). GRP concentrations increased during hypoglycaemia (p < 0.01) while a reduction in AVP occurred at the start of... (More)
The changes in plasma gastrin-releasing peptide (GRP), arginine vasopressin (AVP), neuropeptide Y (NPY), corticotropin releasing hormone (CRH), galanin, ACTH, cortisol, delta sleep-inducing peptide (DSIP), adrenaline, noradrenaline and pancreatic polypeptide (PP) were measured after 5 and 15 minutes of acute insulin-induced moderate hypoglycaemia (2.0 mmol/l) in 10 patients with Type 1 diabetes mellitus with no autonomic neuropathy and in 10 healthy subjects. Plasma catecholamine and PP levels rose in both groups in response to hypoglycemia and the secretory response of ACTH was lower in the diabetic subjects (p < 0.01). GRP concentrations increased during hypoglycaemia (p < 0.01) while a reduction in AVP occurred at the start of hypoglycaemia (p < 0.001). The plasma AVP concentrations were higher in the diabetic group compared with those in the normal group (p < 0.05). The NPY concentrations were higher in the normal subjects (p < 0.05) but no change in the mean level occurred in either group during hypoglycaemia. No group differences or changes in mean plasma concentrations were found for galanin, DSIP and CRH. These observations support the view that regulatory peptides, if involved in glucose homeostasis, may rather have a modulatory effect than a direct action in restoring normoglycaemia. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Research (Edinburgh, Scotland)
volume
20
issue
3
pages
73 - 85
publisher
Teviot-Kimpton
external identifiers
  • pmid:1285360
  • scopus:0027012143
ISSN
0265-5985
language
English
LU publication?
yes
id
22521886-34ae-42e1-9954-57e8e3b878ab (old id 1106598)
date added to LUP
2008-08-12 08:52:33
date last changed
2017-01-01 07:13:47
@article{22521886-34ae-42e1-9954-57e8e3b878ab,
  abstract     = {The changes in plasma gastrin-releasing peptide (GRP), arginine vasopressin (AVP), neuropeptide Y (NPY), corticotropin releasing hormone (CRH), galanin, ACTH, cortisol, delta sleep-inducing peptide (DSIP), adrenaline, noradrenaline and pancreatic polypeptide (PP) were measured after 5 and 15 minutes of acute insulin-induced moderate hypoglycaemia (2.0 mmol/l) in 10 patients with Type 1 diabetes mellitus with no autonomic neuropathy and in 10 healthy subjects. Plasma catecholamine and PP levels rose in both groups in response to hypoglycemia and the secretory response of ACTH was lower in the diabetic subjects (p &lt; 0.01). GRP concentrations increased during hypoglycaemia (p &lt; 0.01) while a reduction in AVP occurred at the start of hypoglycaemia (p &lt; 0.001). The plasma AVP concentrations were higher in the diabetic group compared with those in the normal group (p &lt; 0.05). The NPY concentrations were higher in the normal subjects (p &lt; 0.05) but no change in the mean level occurred in either group during hypoglycaemia. No group differences or changes in mean plasma concentrations were found for galanin, DSIP and CRH. These observations support the view that regulatory peptides, if involved in glucose homeostasis, may rather have a modulatory effect than a direct action in restoring normoglycaemia.},
  author       = {Tallroth, G and Ryding, Erik and Ekman, R and Agardh, Carl-David},
  issn         = {0265-5985},
  language     = {eng},
  number       = {3},
  pages        = {73--85},
  publisher    = {Teviot-Kimpton},
  series       = {Diabetes Research (Edinburgh, Scotland)},
  title        = {The response of regulatory peptides to moderate hypoglycaemia of short duration in type 1 (insulin-dependent) diabetes mellitus and in normal man},
  volume       = {20},
  year         = {1992},
}