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Neuroendocrine regulatory mechanisms in the choroid plexus-cerebrospinal fluid system

Nilsson, Christer; Lindvall-Axelsson, Maria and Owman, Christer LU (1992) In Brain research. Brain research reviews1989-01-01+01:002005-01-01+01:00 17(2). p.109-138
Abstract
The CSF is often regarded as merely a mechanical support for the brain, as well as an unspecific sink for waste products from the CNS. New methodology in receptor autoradiography, immunohistochemistry and molecular biology has revealed the presence of many different neuroendocrine substances or their corresponding receptors in the main CSF-forming structure, the choroid plexus. Both older research on the sympathetic nerves and recent studies of peptide neurotransmitters in the choroid plexus support a neurogenic regulation of choroid plexus CSF production and other transport functions. Among the endocrine substances present in blood and CSF, 5-HT, ANP, vasopressin and the IGFs have high receptor concentrations in the choroid plexus and... (More)
The CSF is often regarded as merely a mechanical support for the brain, as well as an unspecific sink for waste products from the CNS. New methodology in receptor autoradiography, immunohistochemistry and molecular biology has revealed the presence of many different neuroendocrine substances or their corresponding receptors in the main CSF-forming structure, the choroid plexus. Both older research on the sympathetic nerves and recent studies of peptide neurotransmitters in the choroid plexus support a neurogenic regulation of choroid plexus CSF production and other transport functions. Among the endocrine substances present in blood and CSF, 5-HT, ANP, vasopressin and the IGFs have high receptor concentrations in the choroid plexus and have been shown to influence choroid plexus function. Finally, the choroid plexus produces the growth factor IGF-II and a number of transport proteins, most importantly transthyretin, that might regulate hormone transport from blood to brain. These studies suggest that the choroid plexus-CSF system could constitute an important pathway for neuroendocrine signalling in the brain, although clearcut evidence for such a role is still largely lacking. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Choroid plexus, Cerebrospinal fluid, Neuroendocrine, Central nervous system, Vasoactive intestinal polypeptide, 5-Hydroxytryptamine, Atrial natriuretic peptide, Vasopressin, Insulin-like growth factor, Transthyretin
in
Brain research. Brain research reviews1989-01-01+01:002005-01-01+01:00
volume
17
issue
2
pages
109 - 138
publisher
Elsevier
external identifiers
  • pmid:1393190
  • scopus:0026744517
DOI
10.1016/0165-0173(92)90011-A
language
English
LU publication?
yes
id
8b95e72b-48b0-4e43-ac32-1d18fe457baa (old id 1106658)
date added to LUP
2008-08-08 14:53:19
date last changed
2017-01-01 08:03:38
@article{8b95e72b-48b0-4e43-ac32-1d18fe457baa,
  abstract     = {The CSF is often regarded as merely a mechanical support for the brain, as well as an unspecific sink for waste products from the CNS. New methodology in receptor autoradiography, immunohistochemistry and molecular biology has revealed the presence of many different neuroendocrine substances or their corresponding receptors in the main CSF-forming structure, the choroid plexus. Both older research on the sympathetic nerves and recent studies of peptide neurotransmitters in the choroid plexus support a neurogenic regulation of choroid plexus CSF production and other transport functions. Among the endocrine substances present in blood and CSF, 5-HT, ANP, vasopressin and the IGFs have high receptor concentrations in the choroid plexus and have been shown to influence choroid plexus function. Finally, the choroid plexus produces the growth factor IGF-II and a number of transport proteins, most importantly transthyretin, that might regulate hormone transport from blood to brain. These studies suggest that the choroid plexus-CSF system could constitute an important pathway for neuroendocrine signalling in the brain, although clearcut evidence for such a role is still largely lacking.},
  author       = {Nilsson, Christer and Lindvall-Axelsson, Maria and Owman, Christer},
  keyword      = {Choroid plexus,Cerebrospinal fluid,Neuroendocrine,Central nervous system,Vasoactive intestinal polypeptide,5-Hydroxytryptamine,Atrial natriuretic peptide,Vasopressin,Insulin-like growth factor,Transthyretin},
  language     = {eng},
  number       = {2},
  pages        = {109--138},
  publisher    = {Elsevier},
  series       = {Brain research. Brain research reviews1989-01-01+01:002005-01-01+01:00},
  title        = {Neuroendocrine regulatory mechanisms in the choroid plexus-cerebrospinal fluid system},
  url          = {http://dx.doi.org/10.1016/0165-0173(92)90011-A},
  volume       = {17},
  year         = {1992},
}