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The stability of 5-S-cysteinyldopa and 6-hydroxy-5-methoxyindole-2-carboxylic acid in human urine

Kågedal, B; Lenner, L; Arstrand, K and Hansson, Christer LU (1992) In Pigment Cell Research1987-01-01+01:002008-01-01+01:00 p.304-307
Abstract
5-S-cysteinyldopa and 6-hydroxy-5-methoxyindole-2-carboxylic acid are important intermediate metabolites in the formation of cutaneous melanin pigment. Since they both are serious candidates as markers of melanoma progression, their stability in urine has been investigated during storage at various conditions. The results show that storage at -20 degrees C is necessary. Both compounds are nonstable at room temperature, particularly if the urine was not acidified to pH 4-5. Reference levels were obtained from analysis of urine from 31 men and 40 women. The mean (SD) excretion of 5-S-cysteinyldopa was 32 (12.5) mumol/mol creatinine (women). Corresponding figures for 6H5MI2C were 23 (10.3) and 24 (8.1) mumol/mol creatinine for men and women... (More)
5-S-cysteinyldopa and 6-hydroxy-5-methoxyindole-2-carboxylic acid are important intermediate metabolites in the formation of cutaneous melanin pigment. Since they both are serious candidates as markers of melanoma progression, their stability in urine has been investigated during storage at various conditions. The results show that storage at -20 degrees C is necessary. Both compounds are nonstable at room temperature, particularly if the urine was not acidified to pH 4-5. Reference levels were obtained from analysis of urine from 31 men and 40 women. The mean (SD) excretion of 5-S-cysteinyldopa was 32 (12.5) mumol/mol creatinine (women). Corresponding figures for 6H5MI2C were 23 (10.3) and 24 (8.1) mumol/mol creatinine for men and women respectively. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pigment Cell Research1987-01-01+01:002008-01-01+01:00
issue
Suppl 2
pages
304 - 307
publisher
Wiley-Blackwell
external identifiers
  • pmid:1409435
  • scopus:0026472853
ISSN
0893-5785
language
English
LU publication?
yes
id
b7892365-d1a2-4340-b3ee-a2676b75918e (old id 1106701)
date added to LUP
2008-08-04 08:58:24
date last changed
2017-01-01 05:04:29
@article{b7892365-d1a2-4340-b3ee-a2676b75918e,
  abstract     = {5-S-cysteinyldopa and 6-hydroxy-5-methoxyindole-2-carboxylic acid are important intermediate metabolites in the formation of cutaneous melanin pigment. Since they both are serious candidates as markers of melanoma progression, their stability in urine has been investigated during storage at various conditions. The results show that storage at -20 degrees C is necessary. Both compounds are nonstable at room temperature, particularly if the urine was not acidified to pH 4-5. Reference levels were obtained from analysis of urine from 31 men and 40 women. The mean (SD) excretion of 5-S-cysteinyldopa was 32 (12.5) mumol/mol creatinine (women). Corresponding figures for 6H5MI2C were 23 (10.3) and 24 (8.1) mumol/mol creatinine for men and women respectively.},
  author       = {Kågedal, B and Lenner, L and Arstrand, K and Hansson, Christer},
  issn         = {0893-5785},
  language     = {eng},
  number       = {Suppl 2},
  pages        = {304--307},
  publisher    = {Wiley-Blackwell},
  series       = {Pigment Cell Research1987-01-01+01:002008-01-01+01:00},
  title        = {The stability of 5-S-cysteinyldopa and 6-hydroxy-5-methoxyindole-2-carboxylic acid in human urine},
  year         = {1992},
}