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Growth and development of human muscle: a quantitative morphological study of whole vastus lateralis from childhood to adult age

Lexell, Jan LU ; Sjöström, Michael; Nordlund, Ann-Sofie and Taylor, Charles C (1992) In Muscle and Nerve 15(3). p.404-409
Abstract
The mechanisms underlying the increase in volume of muscle tissue, and the functional development of muscle fibers from childhood through adolescence to adult age, have been studied. Cross sections of autopsied whole vastus lateralis muscle from 22 previously physically healthy males, 5 to 37 years of age, were prepared enzyme histochemically (myofibrillar ATPase) and examined morphometrically. The data obtained on muscle cross-sectional area, size, total number, and proportion of type 1 (slow-twitch) and type 2 (fast-twitch) fibers were analyzed using linear regression techniques. The results show that the increase in muscle cross-sectional area from childhood to adult age is caused by an increase in mean fiber size. This is accompanied... (More)
The mechanisms underlying the increase in volume of muscle tissue, and the functional development of muscle fibers from childhood through adolescence to adult age, have been studied. Cross sections of autopsied whole vastus lateralis muscle from 22 previously physically healthy males, 5 to 37 years of age, were prepared enzyme histochemically (myofibrillar ATPase) and examined morphometrically. The data obtained on muscle cross-sectional area, size, total number, and proportion of type 1 (slow-twitch) and type 2 (fast-twitch) fibers were analyzed using linear regression techniques. The results show that the increase in muscle cross-sectional area from childhood to adult age is caused by an increase in mean fiber size. This is accompanied by a functional development of the fiber population: the proportion of type 2 fibers increases significantly from the age of 5 (approx. 35%) to the age of 20 (approx. 50%), which, in the absence of any discernible effect on the total number of fibers, is most likely caused by a transformation of type 1 to type 2 fibers. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
aging, histocytochemistry, growth, muscles, physiological adaptation
in
Muscle and Nerve
volume
15
issue
3
pages
404 - 409
publisher
John Wiley & Sons
external identifiers
  • pmid:1557091
  • scopus:0026606708
ISSN
0148-639X
DOI
10.1002/mus.880150323
language
English
LU publication?
no
id
bb81405e-1e24-485a-883a-1670e2bae9cc (old id 1106711)
date added to LUP
2008-08-04 10:10:24
date last changed
2017-08-13 03:35:54
@article{bb81405e-1e24-485a-883a-1670e2bae9cc,
  abstract     = {The mechanisms underlying the increase in volume of muscle tissue, and the functional development of muscle fibers from childhood through adolescence to adult age, have been studied. Cross sections of autopsied whole vastus lateralis muscle from 22 previously physically healthy males, 5 to 37 years of age, were prepared enzyme histochemically (myofibrillar ATPase) and examined morphometrically. The data obtained on muscle cross-sectional area, size, total number, and proportion of type 1 (slow-twitch) and type 2 (fast-twitch) fibers were analyzed using linear regression techniques. The results show that the increase in muscle cross-sectional area from childhood to adult age is caused by an increase in mean fiber size. This is accompanied by a functional development of the fiber population: the proportion of type 2 fibers increases significantly from the age of 5 (approx. 35%) to the age of 20 (approx. 50%), which, in the absence of any discernible effect on the total number of fibers, is most likely caused by a transformation of type 1 to type 2 fibers.},
  author       = {Lexell, Jan and Sjöström, Michael and Nordlund, Ann-Sofie and Taylor, Charles C},
  issn         = {0148-639X},
  keyword      = {aging,histocytochemistry,growth,muscles,physiological adaptation},
  language     = {eng},
  number       = {3},
  pages        = {404--409},
  publisher    = {John Wiley & Sons},
  series       = {Muscle and Nerve},
  title        = {Growth and development of human muscle: a quantitative morphological study of whole vastus lateralis from childhood to adult age},
  url          = {http://dx.doi.org/10.1002/mus.880150323},
  volume       = {15},
  year         = {1992},
}