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Quantitative morphology of stimulation-induced damage in rabbit fast-twitch skeletal muscles

Lexell, Jan LU ; Jarvis, Jonathan; Downham, David and Salmons, Stanley (1992) In Cell and Tissue Research 269(2). p.195-204
Abstract
The purpose of this study was to examine the contention that stimulation-induced damage, resulting in degeneration with subsequent regeneration, plays a major role in the transformation of fibre type brought about by chronic electrical stimulation. Data from histological and histochemical sections of 9-day-stimulated rabbit fast-twitch muscles were analysed with multivariate statistical techniques. Fibre degeneration and regeneration varied non-systematically between sample areas at any given cross-sectional level. In the extensor digitorum longus muscle, but not in the tibialis anterior, there was more degeneration in proximal than in distal portions of the muscle. The extensor digitorum longus muscle consistently showed more degeneration... (More)
The purpose of this study was to examine the contention that stimulation-induced damage, resulting in degeneration with subsequent regeneration, plays a major role in the transformation of fibre type brought about by chronic electrical stimulation. Data from histological and histochemical sections of 9-day-stimulated rabbit fast-twitch muscles were analysed with multivariate statistical techniques. Fibre degeneration and regeneration varied non-systematically between sample areas at any given cross-sectional level. In the extensor digitorum longus muscle, but not in the tibialis anterior, there was more degeneration in proximal than in distal portions of the muscle. The extensor digitorum longus muscle consistently showed more degeneration than the tibialis anterior muscle. Degeneration was less extensive for an intermittent pattern of stimulation that delivered half the aggregate number of impulses of continuous stimulation. Degeneration and regeneration varied markedly between individual rabbits in each of the groups. Sections that revealed the most degeneration and regeneration also had more fibres that reacted positively with an anti-neonatal antibody. Rigorous analysis of different sources of variation has helped to explain apparent conflicts in the literature. The incidence of muscle fibre damage in the stimulated tibialis anterior muscle is low, showing that the contribution of degenerative-regenerative phenomena to fibre type conversion in this muscle is insignificant. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Histochemistry, Degeneration, Immunohistochemistry, Morphometry, Muscle, Stimulation, chronic, Rabbit
in
Cell and Tissue Research
volume
269
issue
2
pages
195 - 204
publisher
Springer
external identifiers
  • pmid:1423488
  • scopus:0026741851
ISSN
1432-0878
DOI
10.1007/BF00319609
language
English
LU publication?
no
id
c90f0b2e-d34c-4241-9bb5-b32f9a6b8dda (old id 1106716)
date added to LUP
2008-08-04 10:14:32
date last changed
2017-01-01 05:17:16
@article{c90f0b2e-d34c-4241-9bb5-b32f9a6b8dda,
  abstract     = {The purpose of this study was to examine the contention that stimulation-induced damage, resulting in degeneration with subsequent regeneration, plays a major role in the transformation of fibre type brought about by chronic electrical stimulation. Data from histological and histochemical sections of 9-day-stimulated rabbit fast-twitch muscles were analysed with multivariate statistical techniques. Fibre degeneration and regeneration varied non-systematically between sample areas at any given cross-sectional level. In the extensor digitorum longus muscle, but not in the tibialis anterior, there was more degeneration in proximal than in distal portions of the muscle. The extensor digitorum longus muscle consistently showed more degeneration than the tibialis anterior muscle. Degeneration was less extensive for an intermittent pattern of stimulation that delivered half the aggregate number of impulses of continuous stimulation. Degeneration and regeneration varied markedly between individual rabbits in each of the groups. Sections that revealed the most degeneration and regeneration also had more fibres that reacted positively with an anti-neonatal antibody. Rigorous analysis of different sources of variation has helped to explain apparent conflicts in the literature. The incidence of muscle fibre damage in the stimulated tibialis anterior muscle is low, showing that the contribution of degenerative-regenerative phenomena to fibre type conversion in this muscle is insignificant.},
  author       = {Lexell, Jan and Jarvis, Jonathan and Downham, David and Salmons, Stanley},
  issn         = {1432-0878},
  keyword      = {Histochemistry,Degeneration,Immunohistochemistry,Morphometry,Muscle,Stimulation,chronic,Rabbit},
  language     = {eng},
  number       = {2},
  pages        = {195--204},
  publisher    = {Springer},
  series       = {Cell and Tissue Research},
  title        = {Quantitative morphology of stimulation-induced damage in rabbit fast-twitch skeletal muscles},
  url          = {http://dx.doi.org/10.1007/BF00319609},
  volume       = {269},
  year         = {1992},
}