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Serotonin-stimulated phosphoinositide hydrolysis in platelets from post-withdrawal alcoholics

Simonsson, Per LU ; Berglund, Mats LU ; Oreland, Lars; Moberg, Anne-Louise and Alling, Christer LU (1992) In Alcohol and Alcoholism 27(6). p.607-612
Abstract
It has previously been reported that serotonin-stimulated second messenger formation is inhibited in platelets from alcoholics undergoing detoxification. Serotonin-stimulated signal transduction was therefore analysed in platelets from young post-withdrawal alcoholics to elucidate whether the previously reported inhibition is a state or trait marker of alcoholism. No difference between post-withdrawal alcoholics and controls was found with regard to serotonin-stimulated [32P]-phosphatidylinositol 4,5-bisphosphate hydrolysis or [32P]-phosphatidic acid formation. The results indicate that the inhibited serotonin2 receptor function seen in alcoholics undergoing detoxification is a state-dependent rather than a trait-dependent marker.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Alcohol and Alcoholism
volume
27
issue
6
pages
607 - 612
publisher
Oxford University Press
external identifiers
  • pmid:1337965
  • scopus:0027081791
ISSN
1464-3502
language
English
LU publication?
yes
id
b5aab4d1-c787-4b9d-a8a8-e740b4251de1 (old id 1106768)
alternative location
http://alcalc.oxfordjournals.org/cgi/reprint/27/6/607
date added to LUP
2008-08-12 09:24:14
date last changed
2017-07-30 03:52:23
@article{b5aab4d1-c787-4b9d-a8a8-e740b4251de1,
  abstract     = {It has previously been reported that serotonin-stimulated second messenger formation is inhibited in platelets from alcoholics undergoing detoxification. Serotonin-stimulated signal transduction was therefore analysed in platelets from young post-withdrawal alcoholics to elucidate whether the previously reported inhibition is a state or trait marker of alcoholism. No difference between post-withdrawal alcoholics and controls was found with regard to serotonin-stimulated [32P]-phosphatidylinositol 4,5-bisphosphate hydrolysis or [32P]-phosphatidic acid formation. The results indicate that the inhibited serotonin2 receptor function seen in alcoholics undergoing detoxification is a state-dependent rather than a trait-dependent marker.},
  author       = {Simonsson, Per and Berglund, Mats and Oreland, Lars and Moberg, Anne-Louise and Alling, Christer},
  issn         = {1464-3502},
  language     = {eng},
  number       = {6},
  pages        = {607--612},
  publisher    = {Oxford University Press},
  series       = {Alcohol and Alcoholism},
  title        = {Serotonin-stimulated phosphoinositide hydrolysis in platelets from post-withdrawal alcoholics},
  volume       = {27},
  year         = {1992},
}