Advanced

Fasting insulin, calcium metabolism and the electrocardiogram in hypertensive subjects

Lind, L; Hvarfner, Andreas LU ; Pollare, T; Lithell, H and Ljunghall, S (1992) In Journal of Internal Medicine 232(4). p.335-339
Abstract
Changes in both calcium and insulin metabolism have been described in essential hypertension. Low levels of plasma ionized calcium (Ca2+) and high levels of insulin have previously been associated with vascular complications and coronary heart disease. In the present study, indices of calcium metabolism and fasting serum insulin were related to electrocardiographic (ECG) variables in 58 patients with untreated hypertension. Fasting insulin was found to be related to heart rate (r = 0.47, P < 0.001), diastolic interval (r = -0.39, P < 0.004) and electrical axis (r = -0.29, P < 0.03) while Ca2+ was found to be correlated with the QRS amplitude (r = -0.32, P < 0.03) and diastolic interval (r = 0.37, P < 0.02). Furthermore,... (More)
Changes in both calcium and insulin metabolism have been described in essential hypertension. Low levels of plasma ionized calcium (Ca2+) and high levels of insulin have previously been associated with vascular complications and coronary heart disease. In the present study, indices of calcium metabolism and fasting serum insulin were related to electrocardiographic (ECG) variables in 58 patients with untreated hypertension. Fasting insulin was found to be related to heart rate (r = 0.47, P < 0.001), diastolic interval (r = -0.39, P < 0.004) and electrical axis (r = -0.29, P < 0.03) while Ca2+ was found to be correlated with the QRS amplitude (r = -0.32, P < 0.03) and diastolic interval (r = 0.37, P < 0.02). Furthermore, non-ionized serum calcium was correlated with the QRS duration (r = 0.36, P < 0.02), ST-segment interval (r = -0.49, P < 0.002) and QT interval (QoT, r = -0.42, P < 0.008). These correlations were still significant when the influences of age, sex, obesity, blood pressure and heart rate were taken into account in the multiple regression analysis. In conclusion, the present study demonstrates that calcium and insulin metabolism are related to several basic characteristic functions of the heart, such as the systolic and diastolic function, as well as to signs of left ventricular hypertrophy. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Internal Medicine
volume
232
issue
4
pages
335 - 339
publisher
Wiley-Blackwell
external identifiers
  • pmid:1402637
  • scopus:0026646458
ISSN
1365-2796
language
English
LU publication?
yes
id
9db1c2d0-3987-49d3-953a-6ee620cb3c91 (old id 1106825)
date added to LUP
2008-08-04 10:31:34
date last changed
2017-08-06 04:34:33
@article{9db1c2d0-3987-49d3-953a-6ee620cb3c91,
  abstract     = {Changes in both calcium and insulin metabolism have been described in essential hypertension. Low levels of plasma ionized calcium (Ca2+) and high levels of insulin have previously been associated with vascular complications and coronary heart disease. In the present study, indices of calcium metabolism and fasting serum insulin were related to electrocardiographic (ECG) variables in 58 patients with untreated hypertension. Fasting insulin was found to be related to heart rate (r = 0.47, P &lt; 0.001), diastolic interval (r = -0.39, P &lt; 0.004) and electrical axis (r = -0.29, P &lt; 0.03) while Ca2+ was found to be correlated with the QRS amplitude (r = -0.32, P &lt; 0.03) and diastolic interval (r = 0.37, P &lt; 0.02). Furthermore, non-ionized serum calcium was correlated with the QRS duration (r = 0.36, P &lt; 0.02), ST-segment interval (r = -0.49, P &lt; 0.002) and QT interval (QoT, r = -0.42, P &lt; 0.008). These correlations were still significant when the influences of age, sex, obesity, blood pressure and heart rate were taken into account in the multiple regression analysis. In conclusion, the present study demonstrates that calcium and insulin metabolism are related to several basic characteristic functions of the heart, such as the systolic and diastolic function, as well as to signs of left ventricular hypertrophy.},
  author       = {Lind, L and Hvarfner, Andreas and Pollare, T and Lithell, H and Ljunghall, S},
  issn         = {1365-2796},
  language     = {eng},
  number       = {4},
  pages        = {335--339},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Internal Medicine},
  title        = {Fasting insulin, calcium metabolism and the electrocardiogram in hypertensive subjects},
  volume       = {232},
  year         = {1992},
}