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Development of antioxidant enzymes in rat brain and in reaggregation culture of fetal brain cells

Aspberg, Anders LU and Tottmar, O (1992) In Developmental Brain Research 66(1). p.55-58
Abstract
The development of antioxidant enzymes in rat brain and reaggregation cultures of fetal brain cells was studied from embryonic day 15 to postnatal day 45. Both in vivo and in culture, the copper-zinc superoxide dismutase activity first increased and then decreased with age, whereas the manganese superoxide dismutase activity increased throughout the period. Catalase showed a maximum activity at day 5 after birth, thereafter decreasing to adult level around day 30, both in vivo and in culture. The glutathione peroxidase activity increased from the first week after birth and reached adult level at day 45. In culture, the activity of this enzyme was slightly lower. The good correlation between the development of the antioxidant enzymes in... (More)
The development of antioxidant enzymes in rat brain and reaggregation cultures of fetal brain cells was studied from embryonic day 15 to postnatal day 45. Both in vivo and in culture, the copper-zinc superoxide dismutase activity first increased and then decreased with age, whereas the manganese superoxide dismutase activity increased throughout the period. Catalase showed a maximum activity at day 5 after birth, thereafter decreasing to adult level around day 30, both in vivo and in culture. The glutathione peroxidase activity increased from the first week after birth and reached adult level at day 45. In culture, the activity of this enzyme was slightly lower. The good correlation between the development of the antioxidant enzymes in vivo and in culture suggests that reaggregation cultures might be a valuable system for studying defense mechanisms against free radicals in the brain. (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Catalase, Glutathione Peroxidase, Superoxide dismutase, Development, Rat brain, Reaggregation culture
in
Developmental Brain Research
volume
66
issue
1
pages
55 - 58
publisher
Elsevier
external identifiers
  • pmid:1600632
  • scopus:0026514613
ISSN
0165-3806
DOI
10.1016/0165-3806(92)90139-N
language
English
LU publication?
no
id
db9cd06c-4642-48f2-b7cc-674252e016de (old id 1106902)
date added to LUP
2008-07-31 09:23:39
date last changed
2017-10-01 04:51:21
@article{db9cd06c-4642-48f2-b7cc-674252e016de,
  abstract     = {The development of antioxidant enzymes in rat brain and reaggregation cultures of fetal brain cells was studied from embryonic day 15 to postnatal day 45. Both in vivo and in culture, the copper-zinc superoxide dismutase activity first increased and then decreased with age, whereas the manganese superoxide dismutase activity increased throughout the period. Catalase showed a maximum activity at day 5 after birth, thereafter decreasing to adult level around day 30, both in vivo and in culture. The glutathione peroxidase activity increased from the first week after birth and reached adult level at day 45. In culture, the activity of this enzyme was slightly lower. The good correlation between the development of the antioxidant enzymes in vivo and in culture suggests that reaggregation cultures might be a valuable system for studying defense mechanisms against free radicals in the brain.},
  author       = {Aspberg, Anders and Tottmar, O},
  issn         = {0165-3806},
  keyword      = {Catalase,Glutathione Peroxidase,Superoxide dismutase,Development,Rat brain,Reaggregation culture},
  language     = {eng},
  number       = {1},
  pages        = {55--58},
  publisher    = {Elsevier},
  series       = {Developmental Brain Research},
  title        = {Development of antioxidant enzymes in rat brain and in reaggregation culture of fetal brain cells},
  url          = {http://dx.doi.org/10.1016/0165-3806(92)90139-N},
  volume       = {66},
  year         = {1992},
}