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Regulation of lung endothelin content by the glucocorticosteroid budesonide

Andersson, Sven LU ; Zackrisson, Catarina ; Hemsen, Anette and Lundberg, Jan M. (1992) In Biochemical and Biophysical Research Communications 188(3). p.1116-1121
Abstract
Intratracheal instillation of Sephadex beads induced a long-lasting inflammation in the rat lung as seen by an increase in lung weights. Repeated instillation enhanced this reaction and increased lung endothelin-1 content 3.5 times. Budesonide given s.c. abolished these effects and even reduced basal endothelin-1 content by 72%. The tissue content of the sensory neuropeptide neurokinin A were unaffected by both treatments. Endothelin has been proposed to play a part in the pathogenesis of bronchial asthma. If it is so, the ability of budesonide to reduce endothelin-1 content could thus be added to the list of beneficial effects of glucocorticosteroids in these conditions.
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biochemical and Biophysical Research Communications
volume
188
issue
3
pages
1116 - 1121
publisher
Elsevier
external identifiers
  • pmid:1280129
  • scopus:0026486806
ISSN
1090-2104
DOI
10.1016/0006-291X(92)91347-S
language
English
LU publication?
yes
id
d00a118a-560c-40ae-bd3b-cd19c4997f43 (old id 1106914)
date added to LUP
2016-04-01 16:16:55
date last changed
2021-02-07 06:53:27
@article{d00a118a-560c-40ae-bd3b-cd19c4997f43,
  abstract     = {{Intratracheal instillation of Sephadex beads induced a long-lasting inflammation in the rat lung as seen by an increase in lung weights. Repeated instillation enhanced this reaction and increased lung endothelin-1 content 3.5 times. Budesonide given s.c. abolished these effects and even reduced basal endothelin-1 content by 72%. The tissue content of the sensory neuropeptide neurokinin A were unaffected by both treatments. Endothelin has been proposed to play a part in the pathogenesis of bronchial asthma. If it is so, the ability of budesonide to reduce endothelin-1 content could thus be added to the list of beneficial effects of glucocorticosteroids in these conditions.}},
  author       = {{Andersson, Sven and Zackrisson, Catarina and Hemsen, Anette and Lundberg, Jan M.}},
  issn         = {{1090-2104}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{1116--1121}},
  publisher    = {{Elsevier}},
  series       = {{Biochemical and Biophysical Research Communications}},
  title        = {{Regulation of lung endothelin content by the glucocorticosteroid budesonide}},
  url          = {{http://dx.doi.org/10.1016/0006-291X(92)91347-S}},
  doi          = {{10.1016/0006-291X(92)91347-S}},
  volume       = {{188}},
  year         = {{1992}},
}