Advanced

Regulation of lung endothelin content by the glucocorticosteroid budesonide

Andersson, Sven LU ; Zackrisson, Catarina; Hemsen, Anette and Lundberg, Jan M. (1992) In Biochemical and Biophysical Research Communications 188(3). p.1116-1121
Abstract
Intratracheal instillation of Sephadex beads induced a long-lasting inflammation in the rat lung as seen by an increase in lung weights. Repeated instillation enhanced this reaction and increased lung endothelin-1 content 3.5 times. Budesonide given s.c. abolished these effects and even reduced basal endothelin-1 content by 72%. The tissue content of the sensory neuropeptide neurokinin A were unaffected by both treatments. Endothelin has been proposed to play a part in the pathogenesis of bronchial asthma. If it is so, the ability of budesonide to reduce endothelin-1 content could thus be added to the list of beneficial effects of glucocorticosteroids in these conditions.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biochemical and Biophysical Research Communications
volume
188
issue
3
pages
1116 - 1121
publisher
Elsevier
external identifiers
  • pmid:1280129
  • scopus:0026486806
ISSN
1090-2104
DOI
10.1016/0006-291X(92)91347-S
language
English
LU publication?
yes
id
d00a118a-560c-40ae-bd3b-cd19c4997f43 (old id 1106914)
date added to LUP
2008-07-31 08:47:54
date last changed
2017-08-20 04:24:01
@article{d00a118a-560c-40ae-bd3b-cd19c4997f43,
  abstract     = {Intratracheal instillation of Sephadex beads induced a long-lasting inflammation in the rat lung as seen by an increase in lung weights. Repeated instillation enhanced this reaction and increased lung endothelin-1 content 3.5 times. Budesonide given s.c. abolished these effects and even reduced basal endothelin-1 content by 72%. The tissue content of the sensory neuropeptide neurokinin A were unaffected by both treatments. Endothelin has been proposed to play a part in the pathogenesis of bronchial asthma. If it is so, the ability of budesonide to reduce endothelin-1 content could thus be added to the list of beneficial effects of glucocorticosteroids in these conditions.},
  author       = {Andersson, Sven and Zackrisson, Catarina and Hemsen, Anette and Lundberg, Jan M.},
  issn         = {1090-2104},
  language     = {eng},
  number       = {3},
  pages        = {1116--1121},
  publisher    = {Elsevier},
  series       = {Biochemical and Biophysical Research Communications},
  title        = {Regulation of lung endothelin content by the glucocorticosteroid budesonide},
  url          = {http://dx.doi.org/10.1016/0006-291X(92)91347-S},
  volume       = {188},
  year         = {1992},
}