Regulation of lung endothelin content by the glucocorticosteroid budesonide
(1992) In Biochemical and Biophysical Research Communications 188(3). p.1116-1121- Abstract
- Intratracheal instillation of Sephadex beads induced a long-lasting inflammation in the rat lung as seen by an increase in lung weights. Repeated instillation enhanced this reaction and increased lung endothelin-1 content 3.5 times. Budesonide given s.c. abolished these effects and even reduced basal endothelin-1 content by 72%. The tissue content of the sensory neuropeptide neurokinin A were unaffected by both treatments. Endothelin has been proposed to play a part in the pathogenesis of bronchial asthma. If it is so, the ability of budesonide to reduce endothelin-1 content could thus be added to the list of beneficial effects of glucocorticosteroids in these conditions.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1106914
- author
- Andersson, Sven LU ; Zackrisson, Catarina ; Hemsen, Anette and Lundberg, Jan M.
- organization
- publishing date
- 1992
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Biochemical and Biophysical Research Communications
- volume
- 188
- issue
- 3
- pages
- 1116 - 1121
- publisher
- Elsevier
- external identifiers
-
- pmid:1280129
- scopus:0026486806
- ISSN
- 1090-2104
- DOI
- 10.1016/0006-291X(92)91347-S
- language
- English
- LU publication?
- yes
- id
- d00a118a-560c-40ae-bd3b-cd19c4997f43 (old id 1106914)
- date added to LUP
- 2016-04-01 16:16:55
- date last changed
- 2024-01-11 05:09:31
@article{d00a118a-560c-40ae-bd3b-cd19c4997f43, abstract = {{Intratracheal instillation of Sephadex beads induced a long-lasting inflammation in the rat lung as seen by an increase in lung weights. Repeated instillation enhanced this reaction and increased lung endothelin-1 content 3.5 times. Budesonide given s.c. abolished these effects and even reduced basal endothelin-1 content by 72%. The tissue content of the sensory neuropeptide neurokinin A were unaffected by both treatments. Endothelin has been proposed to play a part in the pathogenesis of bronchial asthma. If it is so, the ability of budesonide to reduce endothelin-1 content could thus be added to the list of beneficial effects of glucocorticosteroids in these conditions.}}, author = {{Andersson, Sven and Zackrisson, Catarina and Hemsen, Anette and Lundberg, Jan M.}}, issn = {{1090-2104}}, language = {{eng}}, number = {{3}}, pages = {{1116--1121}}, publisher = {{Elsevier}}, series = {{Biochemical and Biophysical Research Communications}}, title = {{Regulation of lung endothelin content by the glucocorticosteroid budesonide}}, url = {{http://dx.doi.org/10.1016/0006-291X(92)91347-S}}, doi = {{10.1016/0006-291X(92)91347-S}}, volume = {{188}}, year = {{1992}}, }