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Hepatitis C virus infection with progression to hepatocellular carcinoma: a report of five prospectively followed patients in Sweden

Wejstål, Rune; Widell, Anders LU and Norkrans, Gunnar (1993) In Scandinavian Journal of Infectious Diseases 25(4). p.417-420
Abstract
Five Swedish patients with chronic hepatitis C were prospectively followed until hepatocellular carcinoma (HCC) developed. Hepatitis C virus (HCV) antibodies were analysed by a second generation anti-HCV ELISA and a recombinant immunoblot assay (RIBA-2) and viraemia by detection of serum HCV RNA by polymerase chain reaction. Four patients had post transfusion hepatitis and in one patient the source of infection was unknown. HCC developed after 8 to 23 years of mostly asymptomatic disease and all patients died. Four of them were repeatedly biopsied during follow-up and all had chronic active hepatitis. When HCC was diagnosed, cirrhosis was present in all 5. In 4 patients with available sera, anti-HCV was positive and confirmed with RIBA-2,... (More)
Five Swedish patients with chronic hepatitis C were prospectively followed until hepatocellular carcinoma (HCC) developed. Hepatitis C virus (HCV) antibodies were analysed by a second generation anti-HCV ELISA and a recombinant immunoblot assay (RIBA-2) and viraemia by detection of serum HCV RNA by polymerase chain reaction. Four patients had post transfusion hepatitis and in one patient the source of infection was unknown. HCC developed after 8 to 23 years of mostly asymptomatic disease and all patients died. Four of them were repeatedly biopsied during follow-up and all had chronic active hepatitis. When HCC was diagnosed, cirrhosis was present in all 5. In 4 patients with available sera, anti-HCV was positive and confirmed with RIBA-2, whereof 2 were reactive only to the c-22 and c-33c epitopes. HCV-RNA was present in all sera when HCC was diagnosed. Thus, after prolonged disease duration these patients were still viraemic. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Infectious Diseases
volume
25
issue
4
pages
417 - 420
publisher
Informa Healthcare
external identifiers
  • pmid:7504321
  • scopus:0027260739
ISSN
1651-1980
DOI
10.3109/00365549309008521
language
English
LU publication?
yes
id
db79d6bc-a06f-40ae-b452-21a15ac02e79 (old id 1106996)
date added to LUP
2008-07-30 09:06:07
date last changed
2017-01-01 06:59:49
@article{db79d6bc-a06f-40ae-b452-21a15ac02e79,
  abstract     = {Five Swedish patients with chronic hepatitis C were prospectively followed until hepatocellular carcinoma (HCC) developed. Hepatitis C virus (HCV) antibodies were analysed by a second generation anti-HCV ELISA and a recombinant immunoblot assay (RIBA-2) and viraemia by detection of serum HCV RNA by polymerase chain reaction. Four patients had post transfusion hepatitis and in one patient the source of infection was unknown. HCC developed after 8 to 23 years of mostly asymptomatic disease and all patients died. Four of them were repeatedly biopsied during follow-up and all had chronic active hepatitis. When HCC was diagnosed, cirrhosis was present in all 5. In 4 patients with available sera, anti-HCV was positive and confirmed with RIBA-2, whereof 2 were reactive only to the c-22 and c-33c epitopes. HCV-RNA was present in all sera when HCC was diagnosed. Thus, after prolonged disease duration these patients were still viraemic.},
  author       = {Wejstål, Rune and Widell, Anders and Norkrans, Gunnar},
  issn         = {1651-1980},
  language     = {eng},
  number       = {4},
  pages        = {417--420},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Infectious Diseases},
  title        = {Hepatitis C virus infection with progression to hepatocellular carcinoma: a report of five prospectively followed patients in Sweden},
  url          = {http://dx.doi.org/10.3109/00365549309008521},
  volume       = {25},
  year         = {1993},
}