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Prospective malignancy grading, flow cytometry DNA-measurements and adjuvant chemotherapy for invasive squamous cell carcinoma of the uterine cervix

Willen, R; Himmelmann, A; Långström-Einarsson, Eva LU ; Fernö, Mårten LU ; Ranstam, Jonas LU ; Baldetorp, Bo LU ; Skjaerris, J; Prien-Larsen, J; Trope, C and Stendahl, U (1993) In Anticancer Research 13(4). p.1187-1196
Abstract
In a prospective study comprising 310 consecutive patients with carcinoma of the cervix, FIGO stages I-IV, the prognostic significance of clinical and flow cytometric variable was evaluated in a univariate and multivariate analysis. The parameters studied included stage according to FIGO, age, histopathologic grade according to Ackerman and MGS scores, DNA ploidy, S-phase fraction as well as treatment with radiation only, surgery only or a combination thereof as well as adjuvant chemotherapy. Univariate analysis showed that patients in FIGO stages IA-IIA with MGS up to 14 points survived significantly better than other groups. MGS parameter mitosis, vascular invasion and type of invasion predicted survival as did clinical stage. Diploid... (More)
In a prospective study comprising 310 consecutive patients with carcinoma of the cervix, FIGO stages I-IV, the prognostic significance of clinical and flow cytometric variable was evaluated in a univariate and multivariate analysis. The parameters studied included stage according to FIGO, age, histopathologic grade according to Ackerman and MGS scores, DNA ploidy, S-phase fraction as well as treatment with radiation only, surgery only or a combination thereof as well as adjuvant chemotherapy. Univariate analysis showed that patients in FIGO stages IA-IIA with MGS up to 14 points survived significantly better than other groups. MGS parameter mitosis, vascular invasion and type of invasion predicted survival as did clinical stage. Diploid cases with SPF > 15% survived less than remaining other cases. Multivariate analysis not including treatment indicated that FIGO stage and diploid cases with SPF > 15% predicted survival but not total MGS score and age. When treatment for FIGO stages IA-IIA was included, elderly women had a worse prognosis. Adjuvant chemotherapy, surgical alone or radiation alone did not demonstrate any differences within groups. In Figo stages IIB-IV, cases with radiotherapy only survived significantly better than patients with other treatment schedules. The frequency of low malignancy patients (< MGS 16) in relation to year of initial diagnosis was found to have decreased between years 1967 and 1988, probably as a result of screening activities. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Anticancer Research
volume
13
issue
4
pages
1187 - 1196
publisher
International Institute of Cancer Research
external identifiers
  • pmid:8352543
  • scopus:0027169019
ISSN
1791-7530
language
English
LU publication?
yes
id
2b279c93-995d-4ec4-adfa-05f72b35d03f (old id 1107039)
date added to LUP
2008-07-30 09:55:16
date last changed
2017-07-09 03:42:30
@article{2b279c93-995d-4ec4-adfa-05f72b35d03f,
  abstract     = {In a prospective study comprising 310 consecutive patients with carcinoma of the cervix, FIGO stages I-IV, the prognostic significance of clinical and flow cytometric variable was evaluated in a univariate and multivariate analysis. The parameters studied included stage according to FIGO, age, histopathologic grade according to Ackerman and MGS scores, DNA ploidy, S-phase fraction as well as treatment with radiation only, surgery only or a combination thereof as well as adjuvant chemotherapy. Univariate analysis showed that patients in FIGO stages IA-IIA with MGS up to 14 points survived significantly better than other groups. MGS parameter mitosis, vascular invasion and type of invasion predicted survival as did clinical stage. Diploid cases with SPF &gt; 15% survived less than remaining other cases. Multivariate analysis not including treatment indicated that FIGO stage and diploid cases with SPF &gt; 15% predicted survival but not total MGS score and age. When treatment for FIGO stages IA-IIA was included, elderly women had a worse prognosis. Adjuvant chemotherapy, surgical alone or radiation alone did not demonstrate any differences within groups. In Figo stages IIB-IV, cases with radiotherapy only survived significantly better than patients with other treatment schedules. The frequency of low malignancy patients (&lt; MGS 16) in relation to year of initial diagnosis was found to have decreased between years 1967 and 1988, probably as a result of screening activities.},
  author       = {Willen, R and Himmelmann, A and Långström-Einarsson, Eva and Fernö, Mårten and Ranstam, Jonas and Baldetorp, Bo and Skjaerris, J and Prien-Larsen, J and Trope, C and Stendahl, U},
  issn         = {1791-7530},
  language     = {eng},
  number       = {4},
  pages        = {1187--1196},
  publisher    = {International Institute of Cancer Research},
  series       = {Anticancer Research},
  title        = {Prospective malignancy grading, flow cytometry DNA-measurements and adjuvant chemotherapy for invasive squamous cell carcinoma of the uterine cervix},
  volume       = {13},
  year         = {1993},
}