Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture
(1993) In Journal of Bone and Mineral Research 8(10). p.1241-1245- Abstract
- We measured the serum levels of phylloquinone (vitamin K1) and of the menaquinones, MK-7 and MK-8, in a group of 51 women with a mean age of 81 years who were studied within a few hours after a hip fracture. A group of 38 healthy age-matched women randomly chosen from the same population served as controls. Patients with hip fracture had a marked reduction in serum vitamin K1 (336 +/- 302 versus 585 +/- 490 pg/ml, p < 0.01), MK-7 (120 +/- 84 versus 226 +/- 178 pg/ml, p < 0.001), and MK-8 (89 +/- 113 versus 161 +/- 145 pg/ml, p < 0.01), and a large number had undetectable levels, especially of MK-8. Vitamin K levels were not correlated with the time elapsed after fracture or with serum cortisol or other biochemical variables. These... (More)
- We measured the serum levels of phylloquinone (vitamin K1) and of the menaquinones, MK-7 and MK-8, in a group of 51 women with a mean age of 81 years who were studied within a few hours after a hip fracture. A group of 38 healthy age-matched women randomly chosen from the same population served as controls. Patients with hip fracture had a marked reduction in serum vitamin K1 (336 +/- 302 versus 585 +/- 490 pg/ml, p < 0.01), MK-7 (120 +/- 84 versus 226 +/- 178 pg/ml, p < 0.001), and MK-8 (89 +/- 113 versus 161 +/- 145 pg/ml, p < 0.01), and a large number had undetectable levels, especially of MK-8. Vitamin K levels were not correlated with the time elapsed after fracture or with serum cortisol or other biochemical variables. These data suggest that patients with hip fracture have vitamin K deficiency, an abnormality that could affect bone metabolism through an impairment of the gamma carboxylation of the gla-containing proteins of bone. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1107255
- author
- Hodges, S J ; Akesson, K ; Vergnaud, P ; Obrant, Karl LU and Delmas, P D
- publishing date
- 1993
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Bone and Mineral Research
- volume
- 8
- issue
- 10
- pages
- 1241 - 1245
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:8256661
- scopus:0027484982
- ISSN
- 1523-4681
- language
- English
- LU publication?
- no
- id
- 7c2ca24d-e43e-4330-b974-b38a99da1864 (old id 1107255)
- date added to LUP
- 2016-04-01 12:29:02
- date last changed
- 2021-04-11 05:52:51
@article{7c2ca24d-e43e-4330-b974-b38a99da1864, abstract = {{We measured the serum levels of phylloquinone (vitamin K1) and of the menaquinones, MK-7 and MK-8, in a group of 51 women with a mean age of 81 years who were studied within a few hours after a hip fracture. A group of 38 healthy age-matched women randomly chosen from the same population served as controls. Patients with hip fracture had a marked reduction in serum vitamin K1 (336 +/- 302 versus 585 +/- 490 pg/ml, p < 0.01), MK-7 (120 +/- 84 versus 226 +/- 178 pg/ml, p < 0.001), and MK-8 (89 +/- 113 versus 161 +/- 145 pg/ml, p < 0.01), and a large number had undetectable levels, especially of MK-8. Vitamin K levels were not correlated with the time elapsed after fracture or with serum cortisol or other biochemical variables. These data suggest that patients with hip fracture have vitamin K deficiency, an abnormality that could affect bone metabolism through an impairment of the gamma carboxylation of the gla-containing proteins of bone.}}, author = {{Hodges, S J and Akesson, K and Vergnaud, P and Obrant, Karl and Delmas, P D}}, issn = {{1523-4681}}, language = {{eng}}, number = {{10}}, pages = {{1241--1245}}, publisher = {{Wiley-Blackwell}}, series = {{Journal of Bone and Mineral Research}}, title = {{Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture}}, volume = {{8}}, year = {{1993}}, }