Advanced

Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture

Hodges, S J; Akesson, K; Vergnaud, P; Obrant, Karl LU and Delmas, P D (1993) In Journal of Bone and Mineral Research 8(10). p.1241-1245
Abstract
We measured the serum levels of phylloquinone (vitamin K1) and of the menaquinones, MK-7 and MK-8, in a group of 51 women with a mean age of 81 years who were studied within a few hours after a hip fracture. A group of 38 healthy age-matched women randomly chosen from the same population served as controls. Patients with hip fracture had a marked reduction in serum vitamin K1 (336 +/- 302 versus 585 +/- 490 pg/ml, p < 0.01), MK-7 (120 +/- 84 versus 226 +/- 178 pg/ml, p < 0.001), and MK-8 (89 +/- 113 versus 161 +/- 145 pg/ml, p < 0.01), and a large number had undetectable levels, especially of MK-8. Vitamin K levels were not correlated with the time elapsed after fracture or with serum cortisol or other biochemical variables. These... (More)
We measured the serum levels of phylloquinone (vitamin K1) and of the menaquinones, MK-7 and MK-8, in a group of 51 women with a mean age of 81 years who were studied within a few hours after a hip fracture. A group of 38 healthy age-matched women randomly chosen from the same population served as controls. Patients with hip fracture had a marked reduction in serum vitamin K1 (336 +/- 302 versus 585 +/- 490 pg/ml, p < 0.01), MK-7 (120 +/- 84 versus 226 +/- 178 pg/ml, p < 0.001), and MK-8 (89 +/- 113 versus 161 +/- 145 pg/ml, p < 0.01), and a large number had undetectable levels, especially of MK-8. Vitamin K levels were not correlated with the time elapsed after fracture or with serum cortisol or other biochemical variables. These data suggest that patients with hip fracture have vitamin K deficiency, an abnormality that could affect bone metabolism through an impairment of the gamma carboxylation of the gla-containing proteins of bone. (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Bone and Mineral Research
volume
8
issue
10
pages
1241 - 1245
publisher
AMBMR
external identifiers
  • pmid:8256661
  • scopus:0027484982
ISSN
1523-4681
language
English
LU publication?
no
id
7c2ca24d-e43e-4330-b974-b38a99da1864 (old id 1107255)
date added to LUP
2008-07-30 14:35:49
date last changed
2017-08-20 03:46:19
@article{7c2ca24d-e43e-4330-b974-b38a99da1864,
  abstract     = {We measured the serum levels of phylloquinone (vitamin K1) and of the menaquinones, MK-7 and MK-8, in a group of 51 women with a mean age of 81 years who were studied within a few hours after a hip fracture. A group of 38 healthy age-matched women randomly chosen from the same population served as controls. Patients with hip fracture had a marked reduction in serum vitamin K1 (336 +/- 302 versus 585 +/- 490 pg/ml, p &lt; 0.01), MK-7 (120 +/- 84 versus 226 +/- 178 pg/ml, p &lt; 0.001), and MK-8 (89 +/- 113 versus 161 +/- 145 pg/ml, p &lt; 0.01), and a large number had undetectable levels, especially of MK-8. Vitamin K levels were not correlated with the time elapsed after fracture or with serum cortisol or other biochemical variables. These data suggest that patients with hip fracture have vitamin K deficiency, an abnormality that could affect bone metabolism through an impairment of the gamma carboxylation of the gla-containing proteins of bone.},
  author       = {Hodges, S J and Akesson, K and Vergnaud, P and Obrant, Karl and Delmas, P D},
  issn         = {1523-4681},
  language     = {eng},
  number       = {10},
  pages        = {1241--1245},
  publisher    = {AMBMR},
  series       = {Journal of Bone and Mineral Research},
  title        = {Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture},
  volume       = {8},
  year         = {1993},
}