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Effect on cardiac contractile force from addition of cations and oxygen to iohexol. Comparison with other low-osmotic contrast media in the isolated rabbit heart during normal and reduced perfusion pressure

Besjakov, Jack LU ; Bååth, Lars LU ; Almén, Torsten LU and Oksendal, A N (1993) In Acta Radiologica 34(4). p.381-387
Abstract
The coronary arteries of the isolated rabbit heart were perfused with different contrast media (CM). The effects on cardiac contractile force (CF) from enriching iohexol solutions with sodium, calcium, potassium, magnesium and oxygen were investigated. The effects were studied during normal and reduced perfusion pressure; the latter was intended to simulate flow conditions distal to proximal stenotic processes of the coronary arteries. By adding the above mentioned cations to iohexol (175 mg I/ml) the smallest influence on CF was found when the CM contained 30 mM NaCl, 0.3 mM CaCl2, 0.9 mM KCl and 0.3 mM MgCl2 and this influence on CF was significantly less than caused by iohexol with 30 mM NaCl (p < or = 0.01). The influence on CF was... (More)
The coronary arteries of the isolated rabbit heart were perfused with different contrast media (CM). The effects on cardiac contractile force (CF) from enriching iohexol solutions with sodium, calcium, potassium, magnesium and oxygen were investigated. The effects were studied during normal and reduced perfusion pressure; the latter was intended to simulate flow conditions distal to proximal stenotic processes of the coronary arteries. By adding the above mentioned cations to iohexol (175 mg I/ml) the smallest influence on CF was found when the CM contained 30 mM NaCl, 0.3 mM CaCl2, 0.9 mM KCl and 0.3 mM MgCl2 and this influence on CF was significantly less than caused by iohexol with 30 mM NaCl (p < or = 0.01). The influence on CF was further reduced when this iohexol solution was oxygenated with 100% oxygen (p < or = 0.001). This modified iohexol solution caused a significantly smaller influence on CF than the low-osmotic media iohexol, iopamiro, ioversol and ioxaglate (p < or = 0.001). Ioxaglate caused the greatest decrease in CF of all the CM (p < or = 0.001) and to a greater extent during reduced flow than during normal flow (p < or = 0.01). In conclusion, iohexol enriched with a balanced electrolyte solution and saturated with oxygen had a smaller adverse effect on contractility than iohexol, iopamidol, ioversol and ioxaglate. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Radiologica
volume
34
issue
4
pages
381 - 387
publisher
John Wiley & Sons
external identifiers
  • pmid:8318303
  • scopus:0027279853
ISSN
1600-0455
language
English
LU publication?
yes
id
27900361-6d0b-47b7-8ab1-b3f033d7af2a (old id 1107471)
date added to LUP
2008-07-31 09:38:38
date last changed
2017-01-01 06:53:25
@article{27900361-6d0b-47b7-8ab1-b3f033d7af2a,
  abstract     = {The coronary arteries of the isolated rabbit heart were perfused with different contrast media (CM). The effects on cardiac contractile force (CF) from enriching iohexol solutions with sodium, calcium, potassium, magnesium and oxygen were investigated. The effects were studied during normal and reduced perfusion pressure; the latter was intended to simulate flow conditions distal to proximal stenotic processes of the coronary arteries. By adding the above mentioned cations to iohexol (175 mg I/ml) the smallest influence on CF was found when the CM contained 30 mM NaCl, 0.3 mM CaCl2, 0.9 mM KCl and 0.3 mM MgCl2 and this influence on CF was significantly less than caused by iohexol with 30 mM NaCl (p &lt; or = 0.01). The influence on CF was further reduced when this iohexol solution was oxygenated with 100% oxygen (p &lt; or = 0.001). This modified iohexol solution caused a significantly smaller influence on CF than the low-osmotic media iohexol, iopamiro, ioversol and ioxaglate (p &lt; or = 0.001). Ioxaglate caused the greatest decrease in CF of all the CM (p &lt; or = 0.001) and to a greater extent during reduced flow than during normal flow (p &lt; or = 0.01). In conclusion, iohexol enriched with a balanced electrolyte solution and saturated with oxygen had a smaller adverse effect on contractility than iohexol, iopamidol, ioversol and ioxaglate.},
  author       = {Besjakov, Jack and Bååth, Lars and Almén, Torsten and Oksendal, A N},
  issn         = {1600-0455},
  language     = {eng},
  number       = {4},
  pages        = {381--387},
  publisher    = {John Wiley & Sons},
  series       = {Acta Radiologica},
  title        = {Effect on cardiac contractile force from addition of cations and oxygen to iohexol. Comparison with other low-osmotic contrast media in the isolated rabbit heart during normal and reduced perfusion pressure},
  volume       = {34},
  year         = {1993},
}