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Reduced risk of ventricular fibrillation by balancing sodium, calcium, potassium and magnesium added to nonionic contrast media. An investigation in the isolated rabbit heart

Besjakov, Jack LU ; Bååth, Lars LU ; Oksendal, A N and Almén, Torsten LU (1993) In Acta Radiologica 34(3). p.246-251
Abstract
The effect of addition of calcium, potassium and magnesium to iohexol (350 mg I/ml) enriched with 30 mM sodium was investigated with regard to ventricular fibrillation (VF) in isolated rabbit hearts. Enriching iohexol containing 30 mM sodium with increasing amounts of calcium (0-1.2 mM) caused an increase in the frequency of VF. Increasing amounts of potassium (0-3.8 mM) to iohexol with 30 mM Na + 0.15 mM Ca + 0.1 mM Mg reduced the risk of VF. However, this protective effect of potassium on VF was reduced if magnesium was removed from the test solution. Furthermore, increasing amounts of magnesium (0-1.2 mM) to iohexol with 30 mM Na + 0.15 mM Ca + 0.4 mM K led to an increased frequency of VF. Iohexol with 30 mM Na + 0.3 mM Ca + 0.9 mM K +... (More)
The effect of addition of calcium, potassium and magnesium to iohexol (350 mg I/ml) enriched with 30 mM sodium was investigated with regard to ventricular fibrillation (VF) in isolated rabbit hearts. Enriching iohexol containing 30 mM sodium with increasing amounts of calcium (0-1.2 mM) caused an increase in the frequency of VF. Increasing amounts of potassium (0-3.8 mM) to iohexol with 30 mM Na + 0.15 mM Ca + 0.1 mM Mg reduced the risk of VF. However, this protective effect of potassium on VF was reduced if magnesium was removed from the test solution. Furthermore, increasing amounts of magnesium (0-1.2 mM) to iohexol with 30 mM Na + 0.15 mM Ca + 0.4 mM K led to an increased frequency of VF. Iohexol with 30 mM Na + 0.3 mM Ca + 0.9 mM K + 0.3 mM Mg caused no VF. It is of interest to add multiple cations to sodium-containing nonionic media to improve cardiac contractility following coronary perfusion. The present study indicates that it is possible to enrich iohexol 350 mg I/ml + 30 mM Na with calcium, potassium and magnesium in small amounts, and balanced with respect to each ion, without changing the risk of VF. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Radiologica
volume
34
issue
3
pages
246 - 251
publisher
John Wiley & Sons
external identifiers
  • pmid:8489837
  • scopus:0027284090
ISSN
1600-0455
language
English
LU publication?
yes
id
1eba6e34-848f-48d8-aa29-264f012ce3f5 (old id 1107475)
date added to LUP
2008-07-31 09:46:28
date last changed
2017-07-30 04:28:29
@article{1eba6e34-848f-48d8-aa29-264f012ce3f5,
  abstract     = {The effect of addition of calcium, potassium and magnesium to iohexol (350 mg I/ml) enriched with 30 mM sodium was investigated with regard to ventricular fibrillation (VF) in isolated rabbit hearts. Enriching iohexol containing 30 mM sodium with increasing amounts of calcium (0-1.2 mM) caused an increase in the frequency of VF. Increasing amounts of potassium (0-3.8 mM) to iohexol with 30 mM Na + 0.15 mM Ca + 0.1 mM Mg reduced the risk of VF. However, this protective effect of potassium on VF was reduced if magnesium was removed from the test solution. Furthermore, increasing amounts of magnesium (0-1.2 mM) to iohexol with 30 mM Na + 0.15 mM Ca + 0.4 mM K led to an increased frequency of VF. Iohexol with 30 mM Na + 0.3 mM Ca + 0.9 mM K + 0.3 mM Mg caused no VF. It is of interest to add multiple cations to sodium-containing nonionic media to improve cardiac contractility following coronary perfusion. The present study indicates that it is possible to enrich iohexol 350 mg I/ml + 30 mM Na with calcium, potassium and magnesium in small amounts, and balanced with respect to each ion, without changing the risk of VF.},
  author       = {Besjakov, Jack and Bååth, Lars and Oksendal, A N and Almén, Torsten},
  issn         = {1600-0455},
  language     = {eng},
  number       = {3},
  pages        = {246--251},
  publisher    = {John Wiley & Sons},
  series       = {Acta Radiologica},
  title        = {Reduced risk of ventricular fibrillation by balancing sodium, calcium, potassium and magnesium added to nonionic contrast media. An investigation in the isolated rabbit heart},
  volume       = {34},
  year         = {1993},
}