Advanced

Airway inflammation in smokers with nonobstructive and obstructive chronic bronchitis

Linden, M; Rasmussen, J B; Piitulainen, Eeva LU ; Tunek, A; Larson, M; Tegner, H; Venge, P; Laitinen, L A and Brattsand, R (1993) In The American review of respiratory disease 148(5). p.1226-1232
Abstract
To assess the manifestation and location of airway inflammation in smokers with chronic bronchitis (CB) or chronic obstructive pulmonary disease (COPD), we lavaged the airways of 12 smokers with CB and 11 smokers with COPD and coexisting CB (OCB). For comparison, the airways of 5 asymptomatic smokers (AS) and 10 healthy nonsmokers (HNS) were lavaged. In all cases, the first lavage aliquot, labeled "bronchial lavage" (BL), was processed separately from the four subsequent aliquots, which were combined and labeled "bronchoalveolar lavage" (BAL). The composition of BL and BAL fluids indicate an ongoing inflammatory process in the airways of all three groups of smokers. CB patients with obstruction had significantly lower concentrations of... (More)
To assess the manifestation and location of airway inflammation in smokers with chronic bronchitis (CB) or chronic obstructive pulmonary disease (COPD), we lavaged the airways of 12 smokers with CB and 11 smokers with COPD and coexisting CB (OCB). For comparison, the airways of 5 asymptomatic smokers (AS) and 10 healthy nonsmokers (HNS) were lavaged. In all cases, the first lavage aliquot, labeled "bronchial lavage" (BL), was processed separately from the four subsequent aliquots, which were combined and labeled "bronchoalveolar lavage" (BAL). The composition of BL and BAL fluids indicate an ongoing inflammatory process in the airways of all three groups of smokers. CB patients with obstruction had significantly lower concentrations of inflammatory cells in the BL and BAL fluids compared with subjects with nonobstructed CB. Furthermore, airway obstruction, indicated by a reduced FEV1, was significantly correlated with the concentrations of glutathione (p < 0.001), myeloperoxidase (MPO; p < 0.01), and eosinophil cationic protein (ECP; p < 0.01) in BAL fluids. Taken together, these findings suggest that the manifestations of inflammation present in the airways of smokers with CB are different in those who have developed obstruction compared with those who have not. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The American review of respiratory disease
volume
148
issue
5
pages
1226 - 1232
publisher
American Lung Association
external identifiers
  • pmid:8239158
  • scopus:0027331602
ISSN
0003-0805
language
English
LU publication?
yes
id
8091929e-025a-4e13-b5d7-82e3668995e7 (old id 1107509)
date added to LUP
2008-07-31 10:43:04
date last changed
2017-07-30 04:41:05
@article{8091929e-025a-4e13-b5d7-82e3668995e7,
  abstract     = {To assess the manifestation and location of airway inflammation in smokers with chronic bronchitis (CB) or chronic obstructive pulmonary disease (COPD), we lavaged the airways of 12 smokers with CB and 11 smokers with COPD and coexisting CB (OCB). For comparison, the airways of 5 asymptomatic smokers (AS) and 10 healthy nonsmokers (HNS) were lavaged. In all cases, the first lavage aliquot, labeled "bronchial lavage" (BL), was processed separately from the four subsequent aliquots, which were combined and labeled "bronchoalveolar lavage" (BAL). The composition of BL and BAL fluids indicate an ongoing inflammatory process in the airways of all three groups of smokers. CB patients with obstruction had significantly lower concentrations of inflammatory cells in the BL and BAL fluids compared with subjects with nonobstructed CB. Furthermore, airway obstruction, indicated by a reduced FEV1, was significantly correlated with the concentrations of glutathione (p &lt; 0.001), myeloperoxidase (MPO; p &lt; 0.01), and eosinophil cationic protein (ECP; p &lt; 0.01) in BAL fluids. Taken together, these findings suggest that the manifestations of inflammation present in the airways of smokers with CB are different in those who have developed obstruction compared with those who have not.},
  author       = {Linden, M and Rasmussen, J B and Piitulainen, Eeva and Tunek, A and Larson, M and Tegner, H and Venge, P and Laitinen, L A and Brattsand, R},
  issn         = {0003-0805},
  language     = {eng},
  number       = {5},
  pages        = {1226--1232},
  publisher    = {American Lung Association},
  series       = {The American review of respiratory disease},
  title        = {Airway inflammation in smokers with nonobstructive and obstructive chronic bronchitis},
  volume       = {148},
  year         = {1993},
}