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A follow-up study of laboratory animal exposed workers: the influence of atopy for the development of occupational asthma

Sjöstedt, Lars; Willers, Stefan LU and Örbaek, Palle LU (1993) In American Journal of Industrial Medicine 24(4). p.459-469
Abstract
In a 5-year follow-up study of 88 animal exposed laboratory technicians, the incidence of laboratory animal allergy (LAA), lung function, and the development of allergy test reactivity were investigated. Only two individuals developed test positive LAA rhinitis during the follow-up period. Furthermore, one subject who had previously had LAA rhinitis developed LAA asthma. In the remaining subjects the results of skin prick tests against laboratory animals and environmental allergens, total serum IgE levels, and lung function were unchanged. Atopy defined as parental and childhood allergy, raised total serum IgE levels, and positive skin prick tests against nonanimal environmental allergens and nonlaboratory animals (dog and horse) were risk... (More)
In a 5-year follow-up study of 88 animal exposed laboratory technicians, the incidence of laboratory animal allergy (LAA), lung function, and the development of allergy test reactivity were investigated. Only two individuals developed test positive LAA rhinitis during the follow-up period. Furthermore, one subject who had previously had LAA rhinitis developed LAA asthma. In the remaining subjects the results of skin prick tests against laboratory animals and environmental allergens, total serum IgE levels, and lung function were unchanged. Atopy defined as parental and childhood allergy, raised total serum IgE levels, and positive skin prick tests against nonanimal environmental allergens and nonlaboratory animals (dog and horse) were risk indicators for development of test positive LAA asthma. The low incidence of LAA during the 5-year follow-up is interpreted as a result of an early LAA development in atopic subjects. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
LAA, lung function, animal lab work, skin prick testing
in
American Journal of Industrial Medicine
volume
24
issue
4
pages
459 - 469
publisher
John Wiley & Sons
external identifiers
  • pmid:8250064
  • scopus:0027365621
ISSN
0271-3586
DOI
10.1002/ajim.4700240410
language
English
LU publication?
yes
id
5d1aa606-7bff-4498-bd9e-5a1ac1265f39 (old id 1107581)
date added to LUP
2008-07-31 12:58:38
date last changed
2017-08-27 04:21:28
@article{5d1aa606-7bff-4498-bd9e-5a1ac1265f39,
  abstract     = {In a 5-year follow-up study of 88 animal exposed laboratory technicians, the incidence of laboratory animal allergy (LAA), lung function, and the development of allergy test reactivity were investigated. Only two individuals developed test positive LAA rhinitis during the follow-up period. Furthermore, one subject who had previously had LAA rhinitis developed LAA asthma. In the remaining subjects the results of skin prick tests against laboratory animals and environmental allergens, total serum IgE levels, and lung function were unchanged. Atopy defined as parental and childhood allergy, raised total serum IgE levels, and positive skin prick tests against nonanimal environmental allergens and nonlaboratory animals (dog and horse) were risk indicators for development of test positive LAA asthma. The low incidence of LAA during the 5-year follow-up is interpreted as a result of an early LAA development in atopic subjects.},
  author       = {Sjöstedt, Lars and Willers, Stefan and Örbaek, Palle},
  issn         = {0271-3586},
  keyword      = {LAA,lung function,animal lab work,skin prick testing},
  language     = {eng},
  number       = {4},
  pages        = {459--469},
  publisher    = {John Wiley & Sons},
  series       = {American Journal of Industrial Medicine},
  title        = {A follow-up study of laboratory animal exposed workers: the influence of atopy for the development of occupational asthma},
  url          = {http://dx.doi.org/10.1002/ajim.4700240410},
  volume       = {24},
  year         = {1993},
}