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On the relationships between mineral metabolism, obesity and fat distribution

Lind, L; Lithell, H; Hvarfner, Andreas LU ; Pollare, T and Ljunghall, S (1993) In European Journal of Clinical Investigation 23(5). p.307-310
Abstract
Alterations in calcium metabolism have been associated with cardiovascular risk factors. An altered binding of calcium to plasma proteins and raised levels of parathyroid hormone (PTH) have been described in morbid obesity. In the present study, indices of mineral metabolism were related to obesity (body mass index, BMI) and fat distribution (waist to hip ratio, w/h) in 194 subjects with a wide range of BMI and w/h. The ratio of total serum calcium to plasma ionized calcium (Ca2+) was found to be significantly correlated to both BMI (r = 0.20, P < 0.02) and w/h (r = 0.22, P < 0.005). Serum phosphate was also correlated to both of the indices of obesity in an inverse way (r = -0.24, P < 0.0008 for BMI and r = -0.33, P < 0.0001... (More)
Alterations in calcium metabolism have been associated with cardiovascular risk factors. An altered binding of calcium to plasma proteins and raised levels of parathyroid hormone (PTH) have been described in morbid obesity. In the present study, indices of mineral metabolism were related to obesity (body mass index, BMI) and fat distribution (waist to hip ratio, w/h) in 194 subjects with a wide range of BMI and w/h. The ratio of total serum calcium to plasma ionized calcium (Ca2+) was found to be significantly correlated to both BMI (r = 0.20, P < 0.02) and w/h (r = 0.22, P < 0.005). Serum phosphate was also correlated to both of the indices of obesity in an inverse way (r = -0.24, P < 0.0008 for BMI and r = -0.33, P < 0.0001 for w/h). These relationships were still significant when the influences of age, sex and serum creatinine were included in the multiple regression analysis. This kind of analysis also disclosed that w/h was superior to BMI as a determinant of serum phosphate and the total calcium/Ca2+ ratio in serum. PTH was not significantly correlated to any of the indices of obesity. In conclusion, fat distribution rather than obesity per se was found to be associated with an altered mineral metabolism. (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Calcium, obesity, parathyroid hormone, phosphate
in
European Journal of Clinical Investigation
volume
23
issue
5
pages
307 - 310
publisher
Wiley-Blackwell
external identifiers
  • pmid:8354338
  • scopus:0027312187
ISSN
0014-2972
DOI
10.1111/j.1365-2362.1993.tb00779.x
language
English
LU publication?
no
id
464db323-9313-4d9b-875a-373383ea82af (old id 1107584)
date added to LUP
2008-07-31 13:00:50
date last changed
2017-07-02 03:33:01
@article{464db323-9313-4d9b-875a-373383ea82af,
  abstract     = {Alterations in calcium metabolism have been associated with cardiovascular risk factors. An altered binding of calcium to plasma proteins and raised levels of parathyroid hormone (PTH) have been described in morbid obesity. In the present study, indices of mineral metabolism were related to obesity (body mass index, BMI) and fat distribution (waist to hip ratio, w/h) in 194 subjects with a wide range of BMI and w/h. The ratio of total serum calcium to plasma ionized calcium (Ca2+) was found to be significantly correlated to both BMI (r = 0.20, P &lt; 0.02) and w/h (r = 0.22, P &lt; 0.005). Serum phosphate was also correlated to both of the indices of obesity in an inverse way (r = -0.24, P &lt; 0.0008 for BMI and r = -0.33, P &lt; 0.0001 for w/h). These relationships were still significant when the influences of age, sex and serum creatinine were included in the multiple regression analysis. This kind of analysis also disclosed that w/h was superior to BMI as a determinant of serum phosphate and the total calcium/Ca2+ ratio in serum. PTH was not significantly correlated to any of the indices of obesity. In conclusion, fat distribution rather than obesity per se was found to be associated with an altered mineral metabolism.},
  author       = {Lind, L and Lithell, H and Hvarfner, Andreas and Pollare, T and Ljunghall, S},
  issn         = {0014-2972},
  keyword      = {Calcium,obesity,parathyroid hormone,phosphate},
  language     = {eng},
  number       = {5},
  pages        = {307--310},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Clinical Investigation},
  title        = {On the relationships between mineral metabolism, obesity and fat distribution},
  url          = {http://dx.doi.org/10.1111/j.1365-2362.1993.tb00779.x},
  volume       = {23},
  year         = {1993},
}