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Increase in catalase activity in developing rat brain cell reaggregation cultures in the presence of ethanol

Aspberg, Anders LU ; Söderbäck, Maria and Tottmar, Olof (1993) In Biochemical Pharmacology 46(10). p.1873-1876
Abstract
The aim of this investigation was to study the effects of ethanol on antioxidant enzymes in the developing brain, using reaggregation cultures of fetal rat brain cells as a model. The cultures were grown in the presence of 20 and 40 mM ethanol from day 2 until day 44 of the culture period, corresponding to a period in vivo from gestational day 17 to postnatal day 37. The catalase (EC 1.11.1.6) activity was consistently increased at all observation periods, from culture day 11 to day 44, by both doses of ethanol, and an immunoblot showed that the amount of catalase protein was markedly increased. The activities of manganese and copper-zinc superoxide dismutase (EC 1.15.1.1) and glutathione peroxidase (EC 1.11.1.9) were largely unaffected.
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
in
Biochemical Pharmacology
volume
46
issue
10
pages
1873 - 1876
publisher
Elsevier
external identifiers
  • pmid:8250977
  • scopus:0027425724
ISSN
0006-2952
DOI
10.1016/0006-2952(93)90598-Q
language
English
LU publication?
no
id
e069ab87-0b17-4adf-9890-08b7ea69571d (old id 1107663)
date added to LUP
2008-07-31 14:24:50
date last changed
2017-01-01 05:13:14
@article{e069ab87-0b17-4adf-9890-08b7ea69571d,
  abstract     = {The aim of this investigation was to study the effects of ethanol on antioxidant enzymes in the developing brain, using reaggregation cultures of fetal rat brain cells as a model. The cultures were grown in the presence of 20 and 40 mM ethanol from day 2 until day 44 of the culture period, corresponding to a period in vivo from gestational day 17 to postnatal day 37. The catalase (EC 1.11.1.6) activity was consistently increased at all observation periods, from culture day 11 to day 44, by both doses of ethanol, and an immunoblot showed that the amount of catalase protein was markedly increased. The activities of manganese and copper-zinc superoxide dismutase (EC 1.15.1.1) and glutathione peroxidase (EC 1.11.1.9) were largely unaffected.},
  author       = {Aspberg, Anders and Söderbäck, Maria and Tottmar, Olof},
  issn         = {0006-2952},
  language     = {eng},
  number       = {10},
  pages        = {1873--1876},
  publisher    = {Elsevier},
  series       = {Biochemical Pharmacology},
  title        = {Increase in catalase activity in developing rat brain cell reaggregation cultures in the presence of ethanol},
  url          = {http://dx.doi.org/10.1016/0006-2952(93)90598-Q},
  volume       = {46},
  year         = {1993},
}