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The influence of hypoglycaemia on regional cerebral blood flow and cerebral volume in type 1 (insulin-dependent) diabetes mellitus

Tallroth, G; Ryding, Erik LU and Agardh, Carl-David LU (1993) In Diabetologia 36(6). p.530-535
Abstract
The effect of moderate hypoglycaemia (venous blood glucose 2.0 +/- 0.2 mmol/l; mean +/- SD) on regional cerebral blood flow and cerebral volume was studied in a group of ten right-handed patients with Type 1 (insulin-dependent) diabetes mellitus (age 26.0 +/- 2.4 years, duration 18.4 +/- 3.8 years) using an intravenous Xenon 133 single photon emission computed tomography technique. After 10 min of hypoglycaemia, global cerebral blood flow had increased to 55.8 +/- 4.5 ml.100 g-1.min-1 compared to the initial normoglycaemic flow of 49.5 +/- 3.7 ml.100 g-1.min-1 (p < 0.01). A further increase in global cerebral blood flow to 59.5 +/- 4.5 ml.100 g-1.min-1 (p < 0.05) occurred 15 min after normalization of the blood glucose level. The... (More)
The effect of moderate hypoglycaemia (venous blood glucose 2.0 +/- 0.2 mmol/l; mean +/- SD) on regional cerebral blood flow and cerebral volume was studied in a group of ten right-handed patients with Type 1 (insulin-dependent) diabetes mellitus (age 26.0 +/- 2.4 years, duration 18.4 +/- 3.8 years) using an intravenous Xenon 133 single photon emission computed tomography technique. After 10 min of hypoglycaemia, global cerebral blood flow had increased to 55.8 +/- 4.5 ml.100 g-1.min-1 compared to the initial normoglycaemic flow of 49.5 +/- 3.7 ml.100 g-1.min-1 (p < 0.01). A further increase in global cerebral blood flow to 59.5 +/- 4.5 ml.100 g-1.min-1 (p < 0.05) occurred 15 min after normalization of the blood glucose level. The global cerebral blood flow change from before hypoglycaemia to after recovery was inversely related to the initial glucose level. No change in the relative distribution of the regional cerebral blood flow was found between the measurements. The cerebral blood flow was significantly higher in the right hemisphere compared with the left hemisphere (2.3, 1.6 and 2.2%, respectively; p < 0.05) in all measurements. Deeper hypoglycemia was associated with a more pronounced decrease in brain volume, while the length of the restitution time after hypoglycaemia correlated with a volume increase. Due to influences with opposite effects there was no mean change in the brain volume. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Hypoglycaemia, cerebral blood flow, brain volume
in
Diabetologia
volume
36
issue
6
pages
530 - 535
publisher
Springer Verlag
external identifiers
  • pmid:8335175
  • scopus:0027217321
ISSN
1432-0428
DOI
10.1007/BF02743269
language
English
LU publication?
yes
id
3b545620-2f5d-4405-9964-2753884aaa8d (old id 1107697)
date added to LUP
2008-07-31 15:30:55
date last changed
2017-06-11 03:47:45
@article{3b545620-2f5d-4405-9964-2753884aaa8d,
  abstract     = {The effect of moderate hypoglycaemia (venous blood glucose 2.0 +/- 0.2 mmol/l; mean +/- SD) on regional cerebral blood flow and cerebral volume was studied in a group of ten right-handed patients with Type 1 (insulin-dependent) diabetes mellitus (age 26.0 +/- 2.4 years, duration 18.4 +/- 3.8 years) using an intravenous Xenon 133 single photon emission computed tomography technique. After 10 min of hypoglycaemia, global cerebral blood flow had increased to 55.8 +/- 4.5 ml.100 g-1.min-1 compared to the initial normoglycaemic flow of 49.5 +/- 3.7 ml.100 g-1.min-1 (p &lt; 0.01). A further increase in global cerebral blood flow to 59.5 +/- 4.5 ml.100 g-1.min-1 (p &lt; 0.05) occurred 15 min after normalization of the blood glucose level. The global cerebral blood flow change from before hypoglycaemia to after recovery was inversely related to the initial glucose level. No change in the relative distribution of the regional cerebral blood flow was found between the measurements. The cerebral blood flow was significantly higher in the right hemisphere compared with the left hemisphere (2.3, 1.6 and 2.2%, respectively; p &lt; 0.05) in all measurements. Deeper hypoglycemia was associated with a more pronounced decrease in brain volume, while the length of the restitution time after hypoglycaemia correlated with a volume increase. Due to influences with opposite effects there was no mean change in the brain volume.},
  author       = {Tallroth, G and Ryding, Erik and Agardh, Carl-David},
  issn         = {1432-0428},
  keyword      = {Hypoglycaemia,cerebral blood flow,brain volume},
  language     = {eng},
  number       = {6},
  pages        = {530--535},
  publisher    = {Springer Verlag},
  series       = {Diabetologia},
  title        = {The influence of hypoglycaemia on regional cerebral blood flow and cerebral volume in type 1 (insulin-dependent) diabetes mellitus},
  url          = {http://dx.doi.org/10.1007/BF02743269},
  volume       = {36},
  year         = {1993},
}