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The predictive value of albuminuria for cardiovascular and renal disease. A 5-year follow-up study of 476 patients with type I diabetes mellitus

Torffvit, Ole LU and Agardh, Carl-David LU (1993) In Journal of Diabetes and its Complications 7(1). p.49-56
Abstract
A 5-year follow-up study of 476 type I adult diabetic patients previously studied cross sectionally revealed that, during the observation period, 19 patients died and 30 developed cardiovascular or renal disease, such as myocardial infarction (n = 8), cerebrovascular disease (n = 3), amputation (n = 6), and renal insufficiency (n = 13). The patients were registered by one and the most-severe event only. The yearly death rate was 8.0 per 1000, compared with the expected death rate of 2.0 for people with corresponding age and sex in the general population. In patients with renal insufficiency, one also had myocardial infarction, and one had had an amputation. The ages of patients who died, with myocardial infarction, cerebrovascular disease,... (More)
A 5-year follow-up study of 476 type I adult diabetic patients previously studied cross sectionally revealed that, during the observation period, 19 patients died and 30 developed cardiovascular or renal disease, such as myocardial infarction (n = 8), cerebrovascular disease (n = 3), amputation (n = 6), and renal insufficiency (n = 13). The patients were registered by one and the most-severe event only. The yearly death rate was 8.0 per 1000, compared with the expected death rate of 2.0 for people with corresponding age and sex in the general population. In patients with renal insufficiency, one also had myocardial infarction, and one had had an amputation. The ages of patients who died, with myocardial infarction, cerebrovascular disease, amputation, or renal insufficiency, were 44.2 +/- 12.7, 41.3 +/- 6.6, 43.7 +/- 13.2, 45.3 +/- 15.7, and 40.8 +/- 9.8 years, respectively. Urinary albumin concentration in a single early morning urine sample was found to be a strong prognostic marker for the development of cardiovascular disease or death. In contrast, age, gender, age at onset and duration of diabetes, levels of blood pressure, serum creatinine, and HbA1c, or presence of hypertension, as well as changes in blood pressure and hBa1c, during the observation period did not influence the survival or incidence of cardiovascular disease. However, blood pressure and HbA1c were associated with increased urinary albumin concentrations during the follow-up period. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Diabetes and its Complications
volume
7
issue
1
pages
49 - 56
publisher
Elsevier
external identifiers
  • pmid:8481551
  • scopus:0027136136
ISSN
1873-460X
DOI
10.1016/1056-8727(93)90024-S
language
English
LU publication?
yes
id
ab845c2c-2579-4edb-b838-28abfba502a2 (old id 1107702)
date added to LUP
2008-07-31 15:40:55
date last changed
2017-08-13 04:29:10
@article{ab845c2c-2579-4edb-b838-28abfba502a2,
  abstract     = {A 5-year follow-up study of 476 type I adult diabetic patients previously studied cross sectionally revealed that, during the observation period, 19 patients died and 30 developed cardiovascular or renal disease, such as myocardial infarction (n = 8), cerebrovascular disease (n = 3), amputation (n = 6), and renal insufficiency (n = 13). The patients were registered by one and the most-severe event only. The yearly death rate was 8.0 per 1000, compared with the expected death rate of 2.0 for people with corresponding age and sex in the general population. In patients with renal insufficiency, one also had myocardial infarction, and one had had an amputation. The ages of patients who died, with myocardial infarction, cerebrovascular disease, amputation, or renal insufficiency, were 44.2 +/- 12.7, 41.3 +/- 6.6, 43.7 +/- 13.2, 45.3 +/- 15.7, and 40.8 +/- 9.8 years, respectively. Urinary albumin concentration in a single early morning urine sample was found to be a strong prognostic marker for the development of cardiovascular disease or death. In contrast, age, gender, age at onset and duration of diabetes, levels of blood pressure, serum creatinine, and HbA1c, or presence of hypertension, as well as changes in blood pressure and hBa1c, during the observation period did not influence the survival or incidence of cardiovascular disease. However, blood pressure and HbA1c were associated with increased urinary albumin concentrations during the follow-up period.},
  author       = {Torffvit, Ole and Agardh, Carl-David},
  issn         = {1873-460X},
  language     = {eng},
  number       = {1},
  pages        = {49--56},
  publisher    = {Elsevier},
  series       = {Journal of Diabetes and its Complications},
  title        = {The predictive value of albuminuria for cardiovascular and renal disease. A 5-year follow-up study of 476 patients with type I diabetes mellitus},
  url          = {http://dx.doi.org/10.1016/1056-8727(93)90024-S},
  volume       = {7},
  year         = {1993},
}