Advanced

Ion channels, electrical activity and insulin secretion

Rorsman, Patrik LU ; Bokvist, K; Ammala, C; Eliasson, L; Renström, Erik LU and Gabel, J (1994) In Diabete & metabolisme 20(2). p.138-145
Abstract
The insulin-secreting pancreatic beta cell is electrically excitable and changes in the membrane potential play an important role in coupling the metabolism of glucose (and other nutrient secretagogues) to the discharge of the insulin-containing granule. The application of the patch-clamp technique, which permits the recordings of the minute currents associated with the opening of individual ion channels, to pancreatic islet cells has revolutionized our understanding of the beta cell electrophysiology. Here we review some of the recent progress in the field. The properties of functionally important ion channels are described and their possible roles are discussed.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabete & metabolisme
volume
20
issue
2
pages
138 - 145
publisher
Masson
external identifiers
  • pmid:7528694
  • scopus:0028619809
ISSN
0338-1684
language
English
LU publication?
yes
id
e38110c9-da53-4eb0-a659-b7782813d755 (old id 1107727)
date added to LUP
2008-07-22 14:24:53
date last changed
2017-06-25 04:26:22
@article{e38110c9-da53-4eb0-a659-b7782813d755,
  abstract     = {The insulin-secreting pancreatic beta cell is electrically excitable and changes in the membrane potential play an important role in coupling the metabolism of glucose (and other nutrient secretagogues) to the discharge of the insulin-containing granule. The application of the patch-clamp technique, which permits the recordings of the minute currents associated with the opening of individual ion channels, to pancreatic islet cells has revolutionized our understanding of the beta cell electrophysiology. Here we review some of the recent progress in the field. The properties of functionally important ion channels are described and their possible roles are discussed.},
  author       = {Rorsman, Patrik and Bokvist, K and Ammala, C and Eliasson, L and Renström, Erik and Gabel, J},
  issn         = {0338-1684},
  language     = {eng},
  number       = {2},
  pages        = {138--145},
  publisher    = {Masson},
  series       = {Diabete & metabolisme},
  title        = {Ion channels, electrical activity and insulin secretion},
  volume       = {20},
  year         = {1994},
}