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Effects of total parenteral nutrition on lipid metabolism in rats

Ekelund, Mats LU ; Roth, B; Trelde, H; Ekström, Ulf LU and Nilsson-Ehle, Peter LU (1994) In JPEN 18(6). p.503-509
Abstract
BACKGROUND: The pathophysiologic mechanisms behind the development of liver steatosis during total parenteral nutrition (TPN) and the possible relationship to alterations of lipoprotein lipase activities in different tissues are not fully known. It is also unknown whether continuous and discontinuous administration of TPN affect lipid metabolism differently. METHODS: TPN, including 8.4 g of triglycerides per kilogram per day, was given for 10 days to two groups of male Sprague-Dawley rats that received the infusions discontinuously and continuously, respectively. Freely fed rats were used as controls. RESULTS: TPN led to hyperlipidemia and accumulation of triglycerides in the liver. High-density lipoproteins were enriched in triglycerides,... (More)
BACKGROUND: The pathophysiologic mechanisms behind the development of liver steatosis during total parenteral nutrition (TPN) and the possible relationship to alterations of lipoprotein lipase activities in different tissues are not fully known. It is also unknown whether continuous and discontinuous administration of TPN affect lipid metabolism differently. METHODS: TPN, including 8.4 g of triglycerides per kilogram per day, was given for 10 days to two groups of male Sprague-Dawley rats that received the infusions discontinuously and continuously, respectively. Freely fed rats were used as controls. RESULTS: TPN led to hyperlipidemia and accumulation of triglycerides in the liver. High-density lipoproteins were enriched in triglycerides, whereas high-density lipoprotein cholesterol and phospholipid levels were low. The activities of hepatic lipase were markedly decreased, and lipoprotein lipase activities in adipose tissue and in cardiac muscle were both up-regulated. The increased levels of cholesterol and phospholipids in the serum of TPN animals were more pronounced after discontinuous administration. CONCLUSIONS: TPN including lipids interferes with the normal regulation of lipid metabolism. Although the mechanisms remain obscure, the elevation of lipoprotein lipase activities seems functionally important to accommodate the increased input of triglycerides during TPN. Possibly, the observed alterations in lipase activities may be attributed to a state of hypothyroidism. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
JPEN
volume
18
issue
6
pages
503 - 509
publisher
American Society for Parenteral and Enteral Nutrition
external identifiers
  • pmid:7602725
  • scopus:0028054260
ISSN
0148-6071
DOI
10.1177/0148607194018006503
language
English
LU publication?
yes
id
f82029f4-e69e-44ed-87f6-15894453a441 (old id 1107898)
date added to LUP
2008-07-23 09:38:17
date last changed
2017-01-01 07:20:29
@article{f82029f4-e69e-44ed-87f6-15894453a441,
  abstract     = {BACKGROUND: The pathophysiologic mechanisms behind the development of liver steatosis during total parenteral nutrition (TPN) and the possible relationship to alterations of lipoprotein lipase activities in different tissues are not fully known. It is also unknown whether continuous and discontinuous administration of TPN affect lipid metabolism differently. METHODS: TPN, including 8.4 g of triglycerides per kilogram per day, was given for 10 days to two groups of male Sprague-Dawley rats that received the infusions discontinuously and continuously, respectively. Freely fed rats were used as controls. RESULTS: TPN led to hyperlipidemia and accumulation of triglycerides in the liver. High-density lipoproteins were enriched in triglycerides, whereas high-density lipoprotein cholesterol and phospholipid levels were low. The activities of hepatic lipase were markedly decreased, and lipoprotein lipase activities in adipose tissue and in cardiac muscle were both up-regulated. The increased levels of cholesterol and phospholipids in the serum of TPN animals were more pronounced after discontinuous administration. CONCLUSIONS: TPN including lipids interferes with the normal regulation of lipid metabolism. Although the mechanisms remain obscure, the elevation of lipoprotein lipase activities seems functionally important to accommodate the increased input of triglycerides during TPN. Possibly, the observed alterations in lipase activities may be attributed to a state of hypothyroidism.},
  author       = {Ekelund, Mats and Roth, B and Trelde, H and Ekström, Ulf and Nilsson-Ehle, Peter},
  issn         = {0148-6071},
  language     = {eng},
  number       = {6},
  pages        = {503--509},
  publisher    = {American Society for Parenteral and Enteral Nutrition},
  series       = {JPEN},
  title        = {Effects of total parenteral nutrition on lipid metabolism in rats},
  url          = {http://dx.doi.org/10.1177/0148607194018006503},
  volume       = {18},
  year         = {1994},
}