Advanced

Viktigt att upptäcka ärftliga fall av kolorektal- och endometriecancer. Mutationer hos »HNPCC-individer» kan orsaka flera tumörsjukdomar

Nilbert, Mef LU ; Grönberg, Henrik and Lindblom, Annika (2002) In Läkartidningen 99(34). p.300-3296
Abstract
Hereditary Nonpolyposis Colorectal Cancer (HNPCC) is one of our most common hereditary cancer syndromes and confers an increased risk for several tumor types, with the greatest lifetime risks being for colorectal cancer and endometrial cancer. Hereditary mutations in one of several mismatch-repair (MMR) genes cause the syndrome, and 39 such mutations, involving the genes MLH1, MSH2 and MSH6, have been been characterized in Sweden. Screening programs for HNPCC have been shown to be cost-effective and to prevent cancer. Identification of HNPCC individuals thus allows prevention of additional tumors in the patient as well as in the family.
Please use this url to cite or link to this publication:
author
organization
alternative title
Essential to discover hereditary colorectal and endometrial cancer.
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Genetic Screening: economics, Genetic Predisposition to Disease, prevention & control, Genetic Counseling, Hereditary Nonpolyposis: complications, genetics, pathology, Cost-Benefit Analysis, Endometrial Neoplasms: genetics, Mutation: genetics, Base Pair Mismatch, Colorectal Neoplasms: genetics, Colorectal Neoplasms
in
Läkartidningen
volume
99
issue
34
pages
300 - 3296
publisher
Swedish Medical Association
external identifiers
  • scopus:0037158765
ISSN
0023-7205
language
Swedish
LU publication?
yes
id
1257c12b-f974-4130-b707-cd1fb40a2e42 (old id 110794)
alternative location
http://ltarkiv.lakartidningen.se/artNo25242
date added to LUP
2007-07-19 09:31:39
date last changed
2017-01-01 07:16:08
@article{1257c12b-f974-4130-b707-cd1fb40a2e42,
  abstract     = {Hereditary Nonpolyposis Colorectal Cancer (HNPCC) is one of our most common hereditary cancer syndromes and confers an increased risk for several tumor types, with the greatest lifetime risks being for colorectal cancer and endometrial cancer. Hereditary mutations in one of several mismatch-repair (MMR) genes cause the syndrome, and 39 such mutations, involving the genes MLH1, MSH2 and MSH6, have been been characterized in Sweden. Screening programs for HNPCC have been shown to be cost-effective and to prevent cancer. Identification of HNPCC individuals thus allows prevention of additional tumors in the patient as well as in the family.},
  author       = {Nilbert, Mef and Grönberg, Henrik and Lindblom, Annika},
  issn         = {0023-7205},
  keyword      = {Genetic Screening: economics,Genetic Predisposition to Disease,prevention & control,Genetic Counseling,Hereditary Nonpolyposis: complications,genetics,pathology,Cost-Benefit Analysis,Endometrial Neoplasms: genetics,Mutation: genetics,Base Pair Mismatch,Colorectal Neoplasms: genetics,Colorectal Neoplasms},
  language     = {swe},
  number       = {34},
  pages        = {300--3296},
  publisher    = {Swedish Medical Association},
  series       = {Läkartidningen},
  title        = {Viktigt att upptäcka ärftliga fall av kolorektal- och endometriecancer. Mutationer hos »HNPCC-individer» kan orsaka flera tumörsjukdomar},
  volume       = {99},
  year         = {2002},
}