Viktigt att upptäcka ärftliga fall av kolorektal- och endometriecancer. Mutationer hos »HNPCC-individer» kan orsaka flera tumörsjukdomar
(2002) In Läkartidningen 99(34). p.300-3296- Abstract
- Hereditary Nonpolyposis Colorectal Cancer (HNPCC) is one of our most common hereditary cancer syndromes and confers an increased risk for several tumor types, with the greatest lifetime risks being for colorectal cancer and endometrial cancer. Hereditary mutations in one of several mismatch-repair (MMR) genes cause the syndrome, and 39 such mutations, involving the genes MLH1, MSH2 and MSH6, have been been characterized in Sweden. Screening programs for HNPCC have been shown to be cost-effective and to prevent cancer. Identification of HNPCC individuals thus allows prevention of additional tumors in the patient as well as in the family.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/110794
- author
- Nilbert, Mef LU ; Grönberg, Henrik and Lindblom, Annika
- organization
- alternative title
- Essential to discover hereditary colorectal and endometrial cancer.
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Genetic Screening: economics, Genetic Predisposition to Disease, prevention & control, Genetic Counseling, Hereditary Nonpolyposis: complications, genetics, pathology, Cost-Benefit Analysis, Endometrial Neoplasms: genetics, Mutation: genetics, Base Pair Mismatch, Colorectal Neoplasms: genetics, Colorectal Neoplasms
- in
- Läkartidningen
- volume
- 99
- issue
- 34
- pages
- 300 - 3296
- publisher
- Swedish Medical Association
- external identifiers
-
- scopus:0037158765
- ISSN
- 0023-7205
- language
- Swedish
- LU publication?
- yes
- id
- 1257c12b-f974-4130-b707-cd1fb40a2e42 (old id 110794)
- alternative location
- http://ltarkiv.lakartidningen.se/artNo25242
- date added to LUP
- 2016-04-01 16:49:13
- date last changed
- 2022-04-15 07:10:42
@article{1257c12b-f974-4130-b707-cd1fb40a2e42, abstract = {{Hereditary Nonpolyposis Colorectal Cancer (HNPCC) is one of our most common hereditary cancer syndromes and confers an increased risk for several tumor types, with the greatest lifetime risks being for colorectal cancer and endometrial cancer. Hereditary mutations in one of several mismatch-repair (MMR) genes cause the syndrome, and 39 such mutations, involving the genes MLH1, MSH2 and MSH6, have been been characterized in Sweden. Screening programs for HNPCC have been shown to be cost-effective and to prevent cancer. Identification of HNPCC individuals thus allows prevention of additional tumors in the patient as well as in the family.}}, author = {{Nilbert, Mef and Grönberg, Henrik and Lindblom, Annika}}, issn = {{0023-7205}}, keywords = {{Genetic Screening: economics; Genetic Predisposition to Disease; prevention & control; Genetic Counseling; Hereditary Nonpolyposis: complications; genetics; pathology; Cost-Benefit Analysis; Endometrial Neoplasms: genetics; Mutation: genetics; Base Pair Mismatch; Colorectal Neoplasms: genetics; Colorectal Neoplasms}}, language = {{swe}}, number = {{34}}, pages = {{300--3296}}, publisher = {{Swedish Medical Association}}, series = {{Läkartidningen}}, title = {{Viktigt att upptäcka ärftliga fall av kolorektal- och endometriecancer. Mutationer hos »HNPCC-individer» kan orsaka flera tumörsjukdomar}}, url = {{http://ltarkiv.lakartidningen.se/artNo25242}}, volume = {{99}}, year = {{2002}}, }