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Influence of intensified insulin regimen on quality of life and metabolic control in insulin-dependent diabetes mellitus

Karlson, Björn LU and Agardh, Carl-David LU (1994) In Diabetes Research and Clinical Practice 25(2). p.111-115
Abstract
Seventy-eight non-randomized patients with IDDM, aged 33.8 +/- 9.6 years (mean +/- S.D.), with a duration of diabetes of 16.6 +/- 9.5 years and a HbA1c level of 8.0% +/- 1.5 at baseline were included in the study. The effects of a change from a 3-dose insulin regimen using conventional syringes to a treatment mode using 4 injections per day with a pen injector on metabolic control, perceived distress from diabetes on everyday life and correspondence between expectations and experiences of treatment during a 1-year trial were assessed. The experience measures were registered at baseline and after 3 and 12 months, respectively. HbA1c levels were measured every 3 months. Neither the metabolic control nor the body mass index or rate of... (More)
Seventy-eight non-randomized patients with IDDM, aged 33.8 +/- 9.6 years (mean +/- S.D.), with a duration of diabetes of 16.6 +/- 9.5 years and a HbA1c level of 8.0% +/- 1.5 at baseline were included in the study. The effects of a change from a 3-dose insulin regimen using conventional syringes to a treatment mode using 4 injections per day with a pen injector on metabolic control, perceived distress from diabetes on everyday life and correspondence between expectations and experiences of treatment during a 1-year trial were assessed. The experience measures were registered at baseline and after 3 and 12 months, respectively. HbA1c levels were measured every 3 months. Neither the metabolic control nor the body mass index or rate of hypoglycemic episodes changed during the study period. However, the patients experienced a decreased distress from diabetes, which appeared during the first 3 months and remained unchanged thereafter. The expectations of advantages from the intensified insulin therapy were generally high and were mostly either fulfilled or exceeded by experiences. We conclude that multiple insulin injection therapy, under routine treatment conditions, is subjectively preferable to patients and has favourable effects on their quality of life although something more is required in order to also achieve an improvement of metabolic control. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Insulin regimens, Metabolic control, Quality of life, Insulin-dependent diabetes mellitus
in
Diabetes Research and Clinical Practice
volume
25
issue
2
pages
111 - 115
publisher
Elsevier
external identifiers
  • pmid:7821190
  • scopus:0028030693
ISSN
1872-8227
DOI
10.1016/0168-8227(94)90036-1
language
English
LU publication?
yes
id
734e6721-be9b-458e-a8b4-b4e7f5b11871 (old id 1107955)
date added to LUP
2008-07-23 10:19:40
date last changed
2017-01-01 05:05:44
@article{734e6721-be9b-458e-a8b4-b4e7f5b11871,
  abstract     = {Seventy-eight non-randomized patients with IDDM, aged 33.8 +/- 9.6 years (mean +/- S.D.), with a duration of diabetes of 16.6 +/- 9.5 years and a HbA1c level of 8.0% +/- 1.5 at baseline were included in the study. The effects of a change from a 3-dose insulin regimen using conventional syringes to a treatment mode using 4 injections per day with a pen injector on metabolic control, perceived distress from diabetes on everyday life and correspondence between expectations and experiences of treatment during a 1-year trial were assessed. The experience measures were registered at baseline and after 3 and 12 months, respectively. HbA1c levels were measured every 3 months. Neither the metabolic control nor the body mass index or rate of hypoglycemic episodes changed during the study period. However, the patients experienced a decreased distress from diabetes, which appeared during the first 3 months and remained unchanged thereafter. The expectations of advantages from the intensified insulin therapy were generally high and were mostly either fulfilled or exceeded by experiences. We conclude that multiple insulin injection therapy, under routine treatment conditions, is subjectively preferable to patients and has favourable effects on their quality of life although something more is required in order to also achieve an improvement of metabolic control.},
  author       = {Karlson, Björn and Agardh, Carl-David},
  issn         = {1872-8227},
  keyword      = {Insulin regimens,Metabolic control,Quality of life,Insulin-dependent diabetes mellitus},
  language     = {eng},
  number       = {2},
  pages        = {111--115},
  publisher    = {Elsevier},
  series       = {Diabetes Research and Clinical Practice},
  title        = {Influence of intensified insulin regimen on quality of life and metabolic control in insulin-dependent diabetes mellitus},
  url          = {http://dx.doi.org/10.1016/0168-8227(94)90036-1},
  volume       = {25},
  year         = {1994},
}