Permeability of parietal pleura to liquid and proteins
(1994) In Journal of Applied Physiology 76(2). p.627633 Abstract
 The permselectivity of the parietal pleura was determined in spontaneously breathing anesthetized rabbits and dogs. In rabbits, we injected intrapleurally 5 ml of 1g/dl albumin solution containing 100 microCi of 131Ilabeled albumin plus 100 microCi of either lactate dehydrogenase (LDH) or alpha 2125Imacroglobulin. Dogs received 100 ml of 1g/dl albumin solution containing 100 microCi of 131Ialbumin plus 100 microCi of alpha 2125Imacroglobulin. A transpleural pressure gradient was set, lowering the intracapsular pressure to 30 cmH2O. The solvent drag reflection coefficients (sigma f) were calculated as the ratio between tracer concentrations in capsular and pleural liquid collected at 60180 min. In rabbits sigma f was 0.44 +/ 0.2... (More)
 The permselectivity of the parietal pleura was determined in spontaneously breathing anesthetized rabbits and dogs. In rabbits, we injected intrapleurally 5 ml of 1g/dl albumin solution containing 100 microCi of 131Ilabeled albumin plus 100 microCi of either lactate dehydrogenase (LDH) or alpha 2125Imacroglobulin. Dogs received 100 ml of 1g/dl albumin solution containing 100 microCi of 131Ialbumin plus 100 microCi of alpha 2125Imacroglobulin. A transpleural pressure gradient was set, lowering the intracapsular pressure to 30 cmH2O. The solvent drag reflection coefficients (sigma f) were calculated as the ratio between tracer concentrations in capsular and pleural liquid collected at 60180 min. In rabbits sigma f was 0.44 +/ 0.2 (SD) for albumin, 0.84 +/ 0.1 for LDH, and 0.93 +/ 0.05 for alpha 2macroglobulin. In dogs sigma f was 0.30 +/ 0.19 for albumin and 0.53 +/ 0.15 for alpha 2macroglobulin. The hydraulic conductivity of the parietal pleura was 2.18 +/ 1.54 microliters.h1.cmH2O1.cm2 in rabbits and 1.22 +/ 1.13 microliters.h1.cmH2O1.cm2 in dogs. The parietal pleura could be modeled by two pore populations with radii of 8389 and 156222 A. The permeability coefficient averaged 0.080.21 x 10(6) cm/s for albumin, 0.060.09 x 10(6) cm/s for LDH, and 0.010.03 x 10(6) cm/s for alpha 2macroglobulin. (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/record/1107991
 author
 Negrini, D; Venturoli, Daniele ^{LU} ; Townsley, M I and Reed, R K
 organization
 publishing date
 1994
 type
 Contribution to journal
 publication status
 published
 subject
 in
 Journal of Applied Physiology
 volume
 76
 issue
 2
 pages
 627  633
 publisher
 American Physiological Society
 external identifiers

 pmid:7513686
 scopus:0028266082
 ISSN
 15221601
 language
 English
 LU publication?
 yes
 id
 69b0447352774b71a561e28405bf7d7d (old id 1107991)
 alternative location
 http://jap.physiology.org/cgi/reprint/76/2/627
 date added to LUP
 20080723 10:54:38
 date last changed
 20180225 03:30:17
@article{69b0447352774b71a561e28405bf7d7d, abstract = {The permselectivity of the parietal pleura was determined in spontaneously breathing anesthetized rabbits and dogs. In rabbits, we injected intrapleurally 5 ml of 1g/dl albumin solution containing 100 microCi of 131Ilabeled albumin plus 100 microCi of either lactate dehydrogenase (LDH) or alpha 2125Imacroglobulin. Dogs received 100 ml of 1g/dl albumin solution containing 100 microCi of 131Ialbumin plus 100 microCi of alpha 2125Imacroglobulin. A transpleural pressure gradient was set, lowering the intracapsular pressure to 30 cmH2O. The solvent drag reflection coefficients (sigma f) were calculated as the ratio between tracer concentrations in capsular and pleural liquid collected at 60180 min. In rabbits sigma f was 0.44 +/ 0.2 (SD) for albumin, 0.84 +/ 0.1 for LDH, and 0.93 +/ 0.05 for alpha 2macroglobulin. In dogs sigma f was 0.30 +/ 0.19 for albumin and 0.53 +/ 0.15 for alpha 2macroglobulin. The hydraulic conductivity of the parietal pleura was 2.18 +/ 1.54 microliters.h1.cmH2O1.cm2 in rabbits and 1.22 +/ 1.13 microliters.h1.cmH2O1.cm2 in dogs. The parietal pleura could be modeled by two pore populations with radii of 8389 and 156222 A. The permeability coefficient averaged 0.080.21 x 10(6) cm/s for albumin, 0.060.09 x 10(6) cm/s for LDH, and 0.010.03 x 10(6) cm/s for alpha 2macroglobulin.}, author = {Negrini, D and Venturoli, Daniele and Townsley, M I and Reed, R K}, issn = {15221601}, language = {eng}, number = {2}, pages = {627633}, publisher = {American Physiological Society}, series = {Journal of Applied Physiology}, title = {Permeability of parietal pleura to liquid and proteins}, volume = {76}, year = {1994}, }