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Urinary excretion rate of NC1 and Tamm-Horsfall protein in the microalbuminuric type I diabetic patient

Torffvit, Ole LU and Agardh, Carl-David LU (1994) In Journal of Diabetes and its Complications 8(2). p.77-83
Abstract
Fifty-six type I diabetic patients with microalbuminuria (albumin excretion rate 20-200 micrograms/min) were characterized as to sex, age, duration of diabetes, smoking habits, blood pressure, glomerular filtration rate, urinary NC1 (the carboxy-terminal domain of collagen IV), and Tamm-Horsfall protein excretion rate. Albumin excretion rate was considered a sign of glomerular damage, NC1 excretion rate a measure of renal basement membrane turnover, and Tamm-Horsfall protein excretion rate a marker for distal tubular function. There were no differences between males and females and between smokers and nonsmokers with respect to blood pressure, body-mass index, albumin excretion rate, glomerular filtration rate, excretion rate of NC1, and... (More)
Fifty-six type I diabetic patients with microalbuminuria (albumin excretion rate 20-200 micrograms/min) were characterized as to sex, age, duration of diabetes, smoking habits, blood pressure, glomerular filtration rate, urinary NC1 (the carboxy-terminal domain of collagen IV), and Tamm-Horsfall protein excretion rate. Albumin excretion rate was considered a sign of glomerular damage, NC1 excretion rate a measure of renal basement membrane turnover, and Tamm-Horsfall protein excretion rate a marker for distal tubular function. There were no differences between males and females and between smokers and nonsmokers with respect to blood pressure, body-mass index, albumin excretion rate, glomerular filtration rate, excretion rate of NC1, and Tamm-Horsfall protein. As a group, the patients with microalbuminuria had normal glomerular filtration rate, excretion rate of NC1, and Tamm-Horsfall protein. The latter was influenced by glycosylated hemoglobin (HbA1c) levels, especially so in patients with an albumin excretion rate less than the median value of 53.0 micrograms/min (r = -0.61, p < 0.01). Furthermore, both excretion rate of NC1 and Tamm-Horsfall protein were increased in patients with high glomerular filtration rate > or = 130 mL min-1 1.73 m-2). There was no association between glomerular filtration rate and HbA1c levels. As glomerular filtration rate is related to kidney size, these observations suggest that patients with a high glomerular filtration rate have an increased mass and turnover of tubular basement membrane.(ABSTRACT TRUNCATED AT 250 WORDS) (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Diabetes and its Complications
volume
8
issue
2
pages
77 - 83
publisher
Elsevier
external identifiers
  • pmid:8061350
  • scopus:0028114905
ISSN
1873-460X
DOI
10.1016/1056-8727(94)90055-8
language
English
LU publication?
yes
id
044be19b-2868-44be-ada3-655c72c5a623 (old id 1108038)
date added to LUP
2008-07-23 11:41:09
date last changed
2017-10-01 04:35:27
@article{044be19b-2868-44be-ada3-655c72c5a623,
  abstract     = {Fifty-six type I diabetic patients with microalbuminuria (albumin excretion rate 20-200 micrograms/min) were characterized as to sex, age, duration of diabetes, smoking habits, blood pressure, glomerular filtration rate, urinary NC1 (the carboxy-terminal domain of collagen IV), and Tamm-Horsfall protein excretion rate. Albumin excretion rate was considered a sign of glomerular damage, NC1 excretion rate a measure of renal basement membrane turnover, and Tamm-Horsfall protein excretion rate a marker for distal tubular function. There were no differences between males and females and between smokers and nonsmokers with respect to blood pressure, body-mass index, albumin excretion rate, glomerular filtration rate, excretion rate of NC1, and Tamm-Horsfall protein. As a group, the patients with microalbuminuria had normal glomerular filtration rate, excretion rate of NC1, and Tamm-Horsfall protein. The latter was influenced by glycosylated hemoglobin (HbA1c) levels, especially so in patients with an albumin excretion rate less than the median value of 53.0 micrograms/min (r = -0.61, p &lt; 0.01). Furthermore, both excretion rate of NC1 and Tamm-Horsfall protein were increased in patients with high glomerular filtration rate &gt; or = 130 mL min-1 1.73 m-2). There was no association between glomerular filtration rate and HbA1c levels. As glomerular filtration rate is related to kidney size, these observations suggest that patients with a high glomerular filtration rate have an increased mass and turnover of tubular basement membrane.(ABSTRACT TRUNCATED AT 250 WORDS)},
  author       = {Torffvit, Ole and Agardh, Carl-David},
  issn         = {1873-460X},
  language     = {eng},
  number       = {2},
  pages        = {77--83},
  publisher    = {Elsevier},
  series       = {Journal of Diabetes and its Complications},
  title        = {Urinary excretion rate of NC1 and Tamm-Horsfall protein in the microalbuminuric type I diabetic patient},
  url          = {http://dx.doi.org/10.1016/1056-8727(94)90055-8},
  volume       = {8},
  year         = {1994},
}