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Resistance to fluoroquinolones in Pseudomonas aeruginosa and Klebsiella pneumoniae

Rydberg, Johan LU ; Larsson, Charlotte U LU and Miörner, Håkan LU (1994) In Scandinavian Journal of Infectious Diseases 26(3). p.317-320
Abstract
The fluoroquinolone sensitivity of Pseudomonas aeruginosa and Klebsiella pneumoniae was studied by determinations of Minimum Inhibitory Concentrations (MICs) of norfloxacin and ciprofloxacin in consecutive clinical isolates. In P. aeruginosa, resistance or reduced susceptibility (MIC > or = 8 mg/l for norfloxacin and > or = 2 mg/l for ciprofloxacin) was found in 17% (9/54) of the isolates. Reduced susceptibility (MIC > or = 2 mg/l for norfloxacin) was found in 12% (10/84) of K. pneumoniae isolates. P. aeruginosa strains isolated in 1991 had reduced susceptibility to both norfloxacin and ciprofloxacin significantly more often than isolates from 1984-85 (p = 0.02). 10/84 K. pneumoniae strains from 1991 had reduced susceptibility to... (More)
The fluoroquinolone sensitivity of Pseudomonas aeruginosa and Klebsiella pneumoniae was studied by determinations of Minimum Inhibitory Concentrations (MICs) of norfloxacin and ciprofloxacin in consecutive clinical isolates. In P. aeruginosa, resistance or reduced susceptibility (MIC > or = 8 mg/l for norfloxacin and > or = 2 mg/l for ciprofloxacin) was found in 17% (9/54) of the isolates. Reduced susceptibility (MIC > or = 2 mg/l for norfloxacin) was found in 12% (10/84) of K. pneumoniae isolates. P. aeruginosa strains isolated in 1991 had reduced susceptibility to both norfloxacin and ciprofloxacin significantly more often than isolates from 1984-85 (p = 0.02). 10/84 K. pneumoniae strains from 1991 had reduced susceptibility to norfloxacin, compared with 1/34 from 1984-85. This difference was not statistically significant (p = 0.11). (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Infectious Diseases
volume
26
issue
3
pages
317 - 320
publisher
Informa Healthcare
external identifiers
  • pmid:7939432
  • scopus:0028237961
ISSN
1651-1980
DOI
10.3109/00365549409011801
language
English
LU publication?
yes
id
52d7b9d2-67cd-44be-840b-f8da0b96057f (old id 1108135)
date added to LUP
2008-07-23 14:34:14
date last changed
2017-06-25 04:30:16
@article{52d7b9d2-67cd-44be-840b-f8da0b96057f,
  abstract     = {The fluoroquinolone sensitivity of Pseudomonas aeruginosa and Klebsiella pneumoniae was studied by determinations of Minimum Inhibitory Concentrations (MICs) of norfloxacin and ciprofloxacin in consecutive clinical isolates. In P. aeruginosa, resistance or reduced susceptibility (MIC > or = 8 mg/l for norfloxacin and > or = 2 mg/l for ciprofloxacin) was found in 17% (9/54) of the isolates. Reduced susceptibility (MIC > or = 2 mg/l for norfloxacin) was found in 12% (10/84) of K. pneumoniae isolates. P. aeruginosa strains isolated in 1991 had reduced susceptibility to both norfloxacin and ciprofloxacin significantly more often than isolates from 1984-85 (p = 0.02). 10/84 K. pneumoniae strains from 1991 had reduced susceptibility to norfloxacin, compared with 1/34 from 1984-85. This difference was not statistically significant (p = 0.11).},
  author       = {Rydberg, Johan and Larsson, Charlotte U and Miörner, Håkan},
  issn         = {1651-1980},
  language     = {eng},
  number       = {3},
  pages        = {317--320},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Infectious Diseases},
  title        = {Resistance to fluoroquinolones in Pseudomonas aeruginosa and Klebsiella pneumoniae},
  url          = {http://dx.doi.org/10.3109/00365549409011801},
  volume       = {26},
  year         = {1994},
}