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Analysis of immunoglobulin isotype levels in acute pneumococcal bacteremia and in convalescence

Ekdahl, K; Rollof, J; Oxelius, Vivi-Anne LU ; Engellau, Jacob LU and Braconier, Jean Henrik LU (1994) In European Journal of Clinical Microbiology & Infectious Diseases 13(5). p.374-378
Abstract
In 48 patients with a history of a pneumococcal bacteremia, serum taken during the acute phase of the infection was analyzed for IgG and IgG subclasses. Once the patients were free of infection, a serum sample was analyzed for IgG, IgG subclasses, IgA and IgM. In an additional 20 patients, it was only possible to analyze serum from the infection-free phase. Seventeen of 48 (35%) patients had reduced levels of total IgG or of one or more of the IgG subclasses during acute disease. Of the 48 patients in whom both acute phase and infection-free phase serum were analyzed, values of IgG (p < 0.001), IgG1 (p < 0.001), IgG2 (p < 0.001), IgG3 (p < 0.01) and IgG4 (p < 0.01) were decreased during the acute infection. During the... (More)
In 48 patients with a history of a pneumococcal bacteremia, serum taken during the acute phase of the infection was analyzed for IgG and IgG subclasses. Once the patients were free of infection, a serum sample was analyzed for IgG, IgG subclasses, IgA and IgM. In an additional 20 patients, it was only possible to analyze serum from the infection-free phase. Seventeen of 48 (35%) patients had reduced levels of total IgG or of one or more of the IgG subclasses during acute disease. Of the 48 patients in whom both acute phase and infection-free phase serum were analyzed, values of IgG (p < 0.001), IgG1 (p < 0.001), IgG2 (p < 0.001), IgG3 (p < 0.01) and IgG4 (p < 0.01) were decreased during the acute infection. During the infection-free phase, 12 of 68 (18%) patients had a recognizable immunodeficiency, including two patients with common variable immunodeficiency. Routine screening for immunoglobulins during the infection-free period could result in the discovery of previously unrecognized immunoglobulin deficiencies in patients with a history of bacteremic pneumococcal infection. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Clinical Microbiology & Infectious Diseases
volume
13
issue
5
pages
374 - 378
publisher
Springer
external identifiers
  • pmid:8070449
  • scopus:0028361044
ISSN
1435-4373
DOI
10.1007/BF01971993
language
English
LU publication?
yes
id
087cbdc3-0ef9-485d-b947-362926cc4642 (old id 1108138)
date added to LUP
2008-07-23 14:38:42
date last changed
2017-08-13 04:29:59
@article{087cbdc3-0ef9-485d-b947-362926cc4642,
  abstract     = {In 48 patients with a history of a pneumococcal bacteremia, serum taken during the acute phase of the infection was analyzed for IgG and IgG subclasses. Once the patients were free of infection, a serum sample was analyzed for IgG, IgG subclasses, IgA and IgM. In an additional 20 patients, it was only possible to analyze serum from the infection-free phase. Seventeen of 48 (35%) patients had reduced levels of total IgG or of one or more of the IgG subclasses during acute disease. Of the 48 patients in whom both acute phase and infection-free phase serum were analyzed, values of IgG (p &lt; 0.001), IgG1 (p &lt; 0.001), IgG2 (p &lt; 0.001), IgG3 (p &lt; 0.01) and IgG4 (p &lt; 0.01) were decreased during the acute infection. During the infection-free phase, 12 of 68 (18%) patients had a recognizable immunodeficiency, including two patients with common variable immunodeficiency. Routine screening for immunoglobulins during the infection-free period could result in the discovery of previously unrecognized immunoglobulin deficiencies in patients with a history of bacteremic pneumococcal infection.},
  author       = {Ekdahl, K and Rollof, J and Oxelius, Vivi-Anne and Engellau, Jacob and Braconier, Jean Henrik},
  issn         = {1435-4373},
  language     = {eng},
  number       = {5},
  pages        = {374--378},
  publisher    = {Springer},
  series       = {European Journal of Clinical Microbiology & Infectious Diseases},
  title        = {Analysis of immunoglobulin isotype levels in acute pneumococcal bacteremia and in convalescence},
  url          = {http://dx.doi.org/10.1007/BF01971993},
  volume       = {13},
  year         = {1994},
}