Analysis of immunoglobulin isotype levels in acute pneumococcal bacteremia and in convalescence
(1994) In European Journal of Clinical Microbiology & Infectious Diseases 13(5). p.374-378- Abstract
- In 48 patients with a history of a pneumococcal bacteremia, serum taken during the acute phase of the infection was analyzed for IgG and IgG subclasses. Once the patients were free of infection, a serum sample was analyzed for IgG, IgG subclasses, IgA and IgM. In an additional 20 patients, it was only possible to analyze serum from the infection-free phase. Seventeen of 48 (35%) patients had reduced levels of total IgG or of one or more of the IgG subclasses during acute disease. Of the 48 patients in whom both acute phase and infection-free phase serum were analyzed, values of IgG (p < 0.001), IgG1 (p < 0.001), IgG2 (p < 0.001), IgG3 (p < 0.01) and IgG4 (p < 0.01) were decreased during the acute infection. During the... (More)
- In 48 patients with a history of a pneumococcal bacteremia, serum taken during the acute phase of the infection was analyzed for IgG and IgG subclasses. Once the patients were free of infection, a serum sample was analyzed for IgG, IgG subclasses, IgA and IgM. In an additional 20 patients, it was only possible to analyze serum from the infection-free phase. Seventeen of 48 (35%) patients had reduced levels of total IgG or of one or more of the IgG subclasses during acute disease. Of the 48 patients in whom both acute phase and infection-free phase serum were analyzed, values of IgG (p < 0.001), IgG1 (p < 0.001), IgG2 (p < 0.001), IgG3 (p < 0.01) and IgG4 (p < 0.01) were decreased during the acute infection. During the infection-free phase, 12 of 68 (18%) patients had a recognizable immunodeficiency, including two patients with common variable immunodeficiency. Routine screening for immunoglobulins during the infection-free period could result in the discovery of previously unrecognized immunoglobulin deficiencies in patients with a history of bacteremic pneumococcal infection. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1108138
- author
- Ekdahl, K ; Rollof, J ; Oxelius, Vivi-Anne LU ; Engellau, Jacob LU and Braconier, Jean Henrik LU
- organization
- publishing date
- 1994
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Clinical Microbiology & Infectious Diseases
- volume
- 13
- issue
- 5
- pages
- 374 - 378
- publisher
- Springer
- external identifiers
-
- pmid:8070449
- scopus:0028361044
- ISSN
- 1435-4373
- DOI
- 10.1007/BF01971993
- language
- English
- LU publication?
- yes
- id
- 087cbdc3-0ef9-485d-b947-362926cc4642 (old id 1108138)
- date added to LUP
- 2016-04-01 17:02:01
- date last changed
- 2021-01-03 03:07:35
@article{087cbdc3-0ef9-485d-b947-362926cc4642, abstract = {{In 48 patients with a history of a pneumococcal bacteremia, serum taken during the acute phase of the infection was analyzed for IgG and IgG subclasses. Once the patients were free of infection, a serum sample was analyzed for IgG, IgG subclasses, IgA and IgM. In an additional 20 patients, it was only possible to analyze serum from the infection-free phase. Seventeen of 48 (35%) patients had reduced levels of total IgG or of one or more of the IgG subclasses during acute disease. Of the 48 patients in whom both acute phase and infection-free phase serum were analyzed, values of IgG (p < 0.001), IgG1 (p < 0.001), IgG2 (p < 0.001), IgG3 (p < 0.01) and IgG4 (p < 0.01) were decreased during the acute infection. During the infection-free phase, 12 of 68 (18%) patients had a recognizable immunodeficiency, including two patients with common variable immunodeficiency. Routine screening for immunoglobulins during the infection-free period could result in the discovery of previously unrecognized immunoglobulin deficiencies in patients with a history of bacteremic pneumococcal infection.}}, author = {{Ekdahl, K and Rollof, J and Oxelius, Vivi-Anne and Engellau, Jacob and Braconier, Jean Henrik}}, issn = {{1435-4373}}, language = {{eng}}, number = {{5}}, pages = {{374--378}}, publisher = {{Springer}}, series = {{European Journal of Clinical Microbiology & Infectious Diseases}}, title = {{Analysis of immunoglobulin isotype levels in acute pneumococcal bacteremia and in convalescence}}, url = {{http://dx.doi.org/10.1007/BF01971993}}, doi = {{10.1007/BF01971993}}, volume = {{13}}, year = {{1994}}, }