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The influence of lithium on the antidiuretic effect of desmopressin.

Callréus, Torbjörn; Holmquist, Ing-Britt LU ; Lundin, Stefan and Höglund, Peter LU (2002) In Journal of Pharmacy and Pharmacology 54(9). p.1279-1285
Abstract
The objective of this study was to investigate the graded influence from lithium on the antidiuretic effects of desmopressin. Eight healthy male subjects participated in this open, randomised cross-over study with two periods comprising 6 days each. For each subject, one of the study days (6th day) was preceded by a period of lithium treatment. On the study days the subjects were orally water loaded to achieve a state of overhydration with a high urine flow rate. When a steady-state diuresis was achieved after approximately 2 h, 0.396 microg of desmopressin was administered intravenously as a bolus injection. An indirect-response model, where desmopressin was assumed to inhibit the elimination of response, was fitted to the urine... (More)
The objective of this study was to investigate the graded influence from lithium on the antidiuretic effects of desmopressin. Eight healthy male subjects participated in this open, randomised cross-over study with two periods comprising 6 days each. For each subject, one of the study days (6th day) was preceded by a period of lithium treatment. On the study days the subjects were orally water loaded to achieve a state of overhydration with a high urine flow rate. When a steady-state diuresis was achieved after approximately 2 h, 0.396 microg of desmopressin was administered intravenously as a bolus injection. An indirect-response model, where desmopressin was assumed to inhibit the elimination of response, was fitted to the urine osmolarity data. The effects of the independent variables, Uflow(baseline) (baseline urine flow rate), R0 (baseline osmolarity) and serum lithium concentration, on IC50 (concentration producing 50% of the maximum inhibition) could be expressed by multiple linear regression. In conclusion, we found that an indirect-response model can be a useful tool in investigating and describing the pharmacodynamic interaction between drugs, in this particular case, between lithium and desmopressin. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Journal of Pharmacy and Pharmacology
volume
54
issue
9
pages
1279 - 1285
publisher
Pharmaceutical Press
external identifiers
  • wos:000178617700014
  • pmid:12356283
  • scopus:0036733781
ISSN
0022-3573
language
English
LU publication?
yes
id
0f9822e5-e5a0-4d37-95e1-c3e0f859f7f0 (old id 110827)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12356283&dopt=Abstract
date added to LUP
2007-07-05 07:38:50
date last changed
2017-01-01 07:24:16
@article{0f9822e5-e5a0-4d37-95e1-c3e0f859f7f0,
  abstract     = {The objective of this study was to investigate the graded influence from lithium on the antidiuretic effects of desmopressin. Eight healthy male subjects participated in this open, randomised cross-over study with two periods comprising 6 days each. For each subject, one of the study days (6th day) was preceded by a period of lithium treatment. On the study days the subjects were orally water loaded to achieve a state of overhydration with a high urine flow rate. When a steady-state diuresis was achieved after approximately 2 h, 0.396 microg of desmopressin was administered intravenously as a bolus injection. An indirect-response model, where desmopressin was assumed to inhibit the elimination of response, was fitted to the urine osmolarity data. The effects of the independent variables, Uflow(baseline) (baseline urine flow rate), R0 (baseline osmolarity) and serum lithium concentration, on IC50 (concentration producing 50% of the maximum inhibition) could be expressed by multiple linear regression. In conclusion, we found that an indirect-response model can be a useful tool in investigating and describing the pharmacodynamic interaction between drugs, in this particular case, between lithium and desmopressin.},
  author       = {Callréus, Torbjörn and Holmquist, Ing-Britt and Lundin, Stefan and Höglund, Peter},
  issn         = {0022-3573},
  language     = {eng},
  number       = {9},
  pages        = {1279--1285},
  publisher    = {Pharmaceutical Press},
  series       = {Journal of Pharmacy and Pharmacology},
  title        = {The influence of lithium on the antidiuretic effect of desmopressin.},
  volume       = {54},
  year         = {2002},
}