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Circulating cell adhesion molecules in bronchial lavage and serum in COPD patients with chronic bronchitis

Riise, G C; Larsson, S; Löfdahl, Claes-Göran LU and Andersson, B A (1994) In European Respiratory Journal 7(9). p.1673-1677
Abstract
The initial phase of inflammation in bronchial asthma appears to be triggered by the expression of leucocyte-endothelial adhesion molecules on endothelial cell surfaces. Cell adhesion molecules (CAMs) cause adhesion of leucocytes to the endothelium prior to their subsequent extravasation into inflamed tissue. We wanted to determine whether circulating intercellular adhesion molecule-1 (cICAM-1) and circulating E-selectin (cE-selectin) could be detected in bronchial lavage fluid and serum in patients with stable chronic obstructive pulmonary disease (COPD) and chronic bronchitis. Bronchoscopy and small volume bronchial lavage was performed in 19 patients with COPD and chronic bronchitis and in 13 control subjects. We found increased mean... (More)
The initial phase of inflammation in bronchial asthma appears to be triggered by the expression of leucocyte-endothelial adhesion molecules on endothelial cell surfaces. Cell adhesion molecules (CAMs) cause adhesion of leucocytes to the endothelium prior to their subsequent extravasation into inflamed tissue. We wanted to determine whether circulating intercellular adhesion molecule-1 (cICAM-1) and circulating E-selectin (cE-selectin) could be detected in bronchial lavage fluid and serum in patients with stable chronic obstructive pulmonary disease (COPD) and chronic bronchitis. Bronchoscopy and small volume bronchial lavage was performed in 19 patients with COPD and chronic bronchitis and in 13 control subjects. We found increased mean levels of cICAM-1 both in serum (481 micrograms.l-1) and in bronchial lavage (24 micrograms.l-1) in the COPD patients as compared to the controls (321 micrograms.l-1 in serum, 15 micrograms.l-1 in lavage). We also found higher mean levels of cE-selectin in serum from the COPD patients (86 micrograms.l-1) compared to controls (50 micrograms.l-1). The serum levels of cE-selectin correlated significantly with lung function measured as forced expiratory volume in one second (FEV1) in percentage of predicted. Patients with significant intrabronchial bacterial colonization had increased levels of serum cE-selectin. Our results indicate that cCAMs may reflect an upregulation of CAMs on endothelial and epithelial airway cells in COPD. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
chronic obstructive pulmonary disease, chronic bronchitis, Bronchial lavage, cell adhesion molecules
in
European Respiratory Journal
volume
7
issue
9
pages
1673 - 1677
publisher
Eur Respiratory Soc
external identifiers
  • pmid:7527787
  • scopus:0028068771
ISSN
1399-3003
language
English
LU publication?
yes
id
b9159f1b-a41d-43bb-b980-874ef9ea9465 (old id 1108297)
alternative location
http://erj.ersjournals.com/cgi/reprint/7/9/1673
date added to LUP
2008-07-23 17:01:00
date last changed
2017-04-09 03:33:05
@article{b9159f1b-a41d-43bb-b980-874ef9ea9465,
  abstract     = {The initial phase of inflammation in bronchial asthma appears to be triggered by the expression of leucocyte-endothelial adhesion molecules on endothelial cell surfaces. Cell adhesion molecules (CAMs) cause adhesion of leucocytes to the endothelium prior to their subsequent extravasation into inflamed tissue. We wanted to determine whether circulating intercellular adhesion molecule-1 (cICAM-1) and circulating E-selectin (cE-selectin) could be detected in bronchial lavage fluid and serum in patients with stable chronic obstructive pulmonary disease (COPD) and chronic bronchitis. Bronchoscopy and small volume bronchial lavage was performed in 19 patients with COPD and chronic bronchitis and in 13 control subjects. We found increased mean levels of cICAM-1 both in serum (481 micrograms.l-1) and in bronchial lavage (24 micrograms.l-1) in the COPD patients as compared to the controls (321 micrograms.l-1 in serum, 15 micrograms.l-1 in lavage). We also found higher mean levels of cE-selectin in serum from the COPD patients (86 micrograms.l-1) compared to controls (50 micrograms.l-1). The serum levels of cE-selectin correlated significantly with lung function measured as forced expiratory volume in one second (FEV1) in percentage of predicted. Patients with significant intrabronchial bacterial colonization had increased levels of serum cE-selectin. Our results indicate that cCAMs may reflect an upregulation of CAMs on endothelial and epithelial airway cells in COPD.},
  author       = {Riise, G C and Larsson, S and Löfdahl, Claes-Göran and Andersson, B A},
  issn         = {1399-3003},
  keyword      = {chronic obstructive pulmonary disease,chronic bronchitis,Bronchial lavage,cell adhesion molecules},
  language     = {eng},
  number       = {9},
  pages        = {1673--1677},
  publisher    = {Eur Respiratory Soc},
  series       = {European Respiratory Journal},
  title        = {Circulating cell adhesion molecules in bronchial lavage and serum in COPD patients with chronic bronchitis},
  volume       = {7},
  year         = {1994},
}