Advanced

Effects of nonionic monomeric and dimeric contrast media on the twitching reaction of the rat. Importance of osmolality and electrolyte content

Bååth, Lars LU ; Besjakov, Jack LU and Pettersson, G (1994) In Investigative Radiology 29(11). p.985-989
Abstract
RATIONALE AND OBJECTIVES. The authors established a rat model of the twitching reaction to contrast media in striated muscle and investigated the influence of nonionic contrast medium on the twitching reaction regarding the nonionic dimer iodixanol compared with the monomer iohexol and the dimer iotrolan. The authors also studied the influences from the electrolyte additions of iodixanol. METHODS. The interval from start of contrast medium injection to start of head movement was compared for iohexol (140 and 350 mg iodine/mL), iodixanol (150 and 320 mg iodine/mL), and iotrolan (300 mg iodine/mL). Comparison was made with mannitol and mannitol containing the same electrolyte concentrations as iodixanol (150 and 320 mg iodine/mL). RESULTS.... (More)
RATIONALE AND OBJECTIVES. The authors established a rat model of the twitching reaction to contrast media in striated muscle and investigated the influence of nonionic contrast medium on the twitching reaction regarding the nonionic dimer iodixanol compared with the monomer iohexol and the dimer iotrolan. The authors also studied the influences from the electrolyte additions of iodixanol. METHODS. The interval from start of contrast medium injection to start of head movement was compared for iohexol (140 and 350 mg iodine/mL), iodixanol (150 and 320 mg iodine/mL), and iotrolan (300 mg iodine/mL). Comparison was made with mannitol and mannitol containing the same electrolyte concentrations as iodixanol (150 and 320 mg iodine/mL). RESULTS. No differences in latency period were found between iohexol 140 mg iodine/mL (isotonic) and 350 mg iodine/mL (880 mOsm/kg). Iodixanol caused a lesser effect on the twitching reaction than the iohexol solutions and iotrolan. When the electrolytes of iodixanol were added to mannitol (300 mOsm/kg), there was a later onset of the twitching reaction than with electrolyte-free mannitol. CONCLUSIONS. Differences in latency period caused by a change in osmolality were not found. The interval for a twitching reaction was longer with iodixanol than with iohexol, iotrolan, and iso-osmolar mannitol. The weak effect of the iodixanol solution was probably partially caused by the electrolyte content. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Investigative Radiology
volume
29
issue
11
pages
985 - 989
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:7890513
  • scopus:0028567304
ISSN
0020-9996
language
English
LU publication?
yes
id
684134f2-978b-438f-b755-b56deb3e5966 (old id 1108379)
date added to LUP
2008-07-24 08:49:56
date last changed
2017-01-01 04:52:54
@article{684134f2-978b-438f-b755-b56deb3e5966,
  abstract     = {RATIONALE AND OBJECTIVES. The authors established a rat model of the twitching reaction to contrast media in striated muscle and investigated the influence of nonionic contrast medium on the twitching reaction regarding the nonionic dimer iodixanol compared with the monomer iohexol and the dimer iotrolan. The authors also studied the influences from the electrolyte additions of iodixanol. METHODS. The interval from start of contrast medium injection to start of head movement was compared for iohexol (140 and 350 mg iodine/mL), iodixanol (150 and 320 mg iodine/mL), and iotrolan (300 mg iodine/mL). Comparison was made with mannitol and mannitol containing the same electrolyte concentrations as iodixanol (150 and 320 mg iodine/mL). RESULTS. No differences in latency period were found between iohexol 140 mg iodine/mL (isotonic) and 350 mg iodine/mL (880 mOsm/kg). Iodixanol caused a lesser effect on the twitching reaction than the iohexol solutions and iotrolan. When the electrolytes of iodixanol were added to mannitol (300 mOsm/kg), there was a later onset of the twitching reaction than with electrolyte-free mannitol. CONCLUSIONS. Differences in latency period caused by a change in osmolality were not found. The interval for a twitching reaction was longer with iodixanol than with iohexol, iotrolan, and iso-osmolar mannitol. The weak effect of the iodixanol solution was probably partially caused by the electrolyte content.},
  author       = {Bååth, Lars and Besjakov, Jack and Pettersson, G},
  issn         = {0020-9996},
  language     = {eng},
  number       = {11},
  pages        = {985--989},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Investigative Radiology},
  title        = {Effects of nonionic monomeric and dimeric contrast media on the twitching reaction of the rat. Importance of osmolality and electrolyte content},
  volume       = {29},
  year         = {1994},
}