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Fibre type composition of rabbit tibialis anterior and extensor digitorum longus muscles

Lexell, Jan LU ; Jarvis, J C; Currie, J; Downham, D Y and Salmons, S (1994) In Journal of Anatomy 185(Pt 1). p.95-101
Abstract
Rabbit tibialis anterior (TA) and extensor digitorum longus (EDL) muscles are used extensively in studies of stimulation-induced fibre type transformation, but the proportions and sizes of the 2 main fibre types, and the way in which they are distributed within the muscles, have never been described in any detail. In this study, transverse sections were processed by enzyme histochemical and immunohistochemical techniques and assessed morphometrically. The data were analysed by multivariate methods. In both TA and EDL muscles, the proportion of type 1 fibres varied significantly, and to a similar extent, within a cross-section, from lateral to medial and from superficial to deep parts. The fibre density, an indirect estimate of the mean... (More)
Rabbit tibialis anterior (TA) and extensor digitorum longus (EDL) muscles are used extensively in studies of stimulation-induced fibre type transformation, but the proportions and sizes of the 2 main fibre types, and the way in which they are distributed within the muscles, have never been described in any detail. In this study, transverse sections were processed by enzyme histochemical and immunohistochemical techniques and assessed morphometrically. The data were analysed by multivariate methods. In both TA and EDL muscles, the proportion of type 1 fibres varied significantly, and to a similar extent, within a cross-section, from lateral to medial and from superficial to deep parts. The fibre density, an indirect estimate of the mean muscle fibre area, also varied significantly, but not systematically, within a cross-section. For the EDL muscle, the proportion of type 1 fibres was consistently higher in the distal than in the proximal part of the muscle. The proportion of type 1 fibres was also significantly higher in the EDL than in the TA muscle for each of the 6 rabbits. There was no systematic variation between muscles from left and right limbs. The type proportions and fibre densities for both TA and EDL muscles differed significantly between individual rabbits, but not between sexes. The study provides a database that has hitherto been lacking on normal fibre type composition and its variation within and between these experimentally important muscles. (Less)
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author
organization
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Contribution to journal
publication status
published
subject
keywords
Muscle histochemistry, immunocytochemistry
in
Journal of Anatomy
volume
185
issue
Pt 1
pages
95 - 101
publisher
John Wiley & Sons
external identifiers
  • pmid:7559119
  • scopus:0028087903
ISSN
0021-8782
language
English
LU publication?
yes
id
50e5c40b-90cc-4d66-9d79-5ef2e673d1e1 (old id 1108409)
alternative location
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1166818
date added to LUP
2008-07-24 09:31:25
date last changed
2017-01-01 04:37:37
@article{50e5c40b-90cc-4d66-9d79-5ef2e673d1e1,
  abstract     = {Rabbit tibialis anterior (TA) and extensor digitorum longus (EDL) muscles are used extensively in studies of stimulation-induced fibre type transformation, but the proportions and sizes of the 2 main fibre types, and the way in which they are distributed within the muscles, have never been described in any detail. In this study, transverse sections were processed by enzyme histochemical and immunohistochemical techniques and assessed morphometrically. The data were analysed by multivariate methods. In both TA and EDL muscles, the proportion of type 1 fibres varied significantly, and to a similar extent, within a cross-section, from lateral to medial and from superficial to deep parts. The fibre density, an indirect estimate of the mean muscle fibre area, also varied significantly, but not systematically, within a cross-section. For the EDL muscle, the proportion of type 1 fibres was consistently higher in the distal than in the proximal part of the muscle. The proportion of type 1 fibres was also significantly higher in the EDL than in the TA muscle for each of the 6 rabbits. There was no systematic variation between muscles from left and right limbs. The type proportions and fibre densities for both TA and EDL muscles differed significantly between individual rabbits, but not between sexes. The study provides a database that has hitherto been lacking on normal fibre type composition and its variation within and between these experimentally important muscles.},
  author       = {Lexell, Jan and Jarvis, J C and Currie, J and Downham, D Y and Salmons, S},
  issn         = {0021-8782},
  keyword      = {Muscle histochemistry,immunocytochemistry},
  language     = {eng},
  number       = {Pt 1},
  pages        = {95--101},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Anatomy},
  title        = {Fibre type composition of rabbit tibialis anterior and extensor digitorum longus muscles},
  volume       = {185},
  year         = {1994},
}