Endocytotic activity of mouse skeletal muscle fibres after long-term denervation
(1994) In Journal of the Neurological Sciences 125(2). p.147-152- Abstract
- The endocytotic activity of skeletal muscle fibres and its relation to the denervated endplate region has been studied using horseradish peroxidase (HRP) as marker for endocytosis. In muscles denervated for a short time period (10-20 days) HRP-uptake occurred in small segments of the muscle fibres near the centre of the muscle (endplate region). After long-term denervation (6-12 months) similar segments with high endocytotic activity were seen preferentially in more peripheral parts of the muscle fibres. Ultrastructural characteristics of segments with high endocytotic activity from long-term denervated muscle fibres include a proliferating transverse tubular system, HRP-containing bodies of different sizes with some very large vacuoles... (More)
- The endocytotic activity of skeletal muscle fibres and its relation to the denervated endplate region has been studied using horseradish peroxidase (HRP) as marker for endocytosis. In muscles denervated for a short time period (10-20 days) HRP-uptake occurred in small segments of the muscle fibres near the centre of the muscle (endplate region). After long-term denervation (6-12 months) similar segments with high endocytotic activity were seen preferentially in more peripheral parts of the muscle fibres. Ultrastructural characteristics of segments with high endocytotic activity from long-term denervated muscle fibres include a proliferating transverse tubular system, HRP-containing bodies of different sizes with some very large vacuoles extending over several sarcomeres. These characteristics are similar to those described previously for HRP-uptake in the endplate region of short-term denervated muscle (Tagerud et al., J. Neurol. Sci., 75 (1986) 141) except that no recognizable endplate structures were observed in the present study. The results are discussed in relation to the fate of the denervated endplate and the receptive capacity for synapse formation in long-term denervated muscle. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1108484
- author
- Vult von Steyern, Fredrik LU ; Libelius, Rolf ; Lawoko, Grace and Tågerud, Sven
- organization
- publishing date
- 1994
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Endocytosis, Muscle, skeletal, Denervation, Endplate, Exocytosis, Lysosomes, Reinnervation
- in
- Journal of the Neurological Sciences
- volume
- 125
- issue
- 2
- pages
- 147 - 152
- publisher
- Elsevier
- external identifiers
-
- pmid:7807159
- scopus:0028129211
- ISSN
- 1878-5883
- DOI
- 10.1016/0022-510X(94)90027-2
- language
- English
- LU publication?
- yes
- id
- b5b3555f-169f-4147-a6fa-7980348fedf6 (old id 1108484)
- date added to LUP
- 2016-04-01 11:41:24
- date last changed
- 2021-01-03 10:02:29
@article{b5b3555f-169f-4147-a6fa-7980348fedf6,
abstract = {{The endocytotic activity of skeletal muscle fibres and its relation to the denervated endplate region has been studied using horseradish peroxidase (HRP) as marker for endocytosis. In muscles denervated for a short time period (10-20 days) HRP-uptake occurred in small segments of the muscle fibres near the centre of the muscle (endplate region). After long-term denervation (6-12 months) similar segments with high endocytotic activity were seen preferentially in more peripheral parts of the muscle fibres. Ultrastructural characteristics of segments with high endocytotic activity from long-term denervated muscle fibres include a proliferating transverse tubular system, HRP-containing bodies of different sizes with some very large vacuoles extending over several sarcomeres. These characteristics are similar to those described previously for HRP-uptake in the endplate region of short-term denervated muscle (Tagerud et al., J. Neurol. Sci., 75 (1986) 141) except that no recognizable endplate structures were observed in the present study. The results are discussed in relation to the fate of the denervated endplate and the receptive capacity for synapse formation in long-term denervated muscle.}},
author = {{Vult von Steyern, Fredrik and Libelius, Rolf and Lawoko, Grace and Tågerud, Sven}},
issn = {{1878-5883}},
keywords = {{Endocytosis; Muscle; skeletal; Denervation; Endplate; Exocytosis; Lysosomes; Reinnervation}},
language = {{eng}},
number = {{2}},
pages = {{147--152}},
publisher = {{Elsevier}},
series = {{Journal of the Neurological Sciences}},
title = {{Endocytotic activity of mouse skeletal muscle fibres after long-term denervation}},
url = {{http://dx.doi.org/10.1016/0022-510X(94)90027-2}},
doi = {{10.1016/0022-510X(94)90027-2}},
volume = {{125}},
year = {{1994}},
}