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Endocytotic activity of mouse skeletal muscle fibres after long-term denervation

Vult von Steyern, Fredrik LU ; Libelius, Rolf; Lawoko, Grace and Tågerud, Sven (1994) In Journal of the Neurological Sciences 125(2). p.147-152
Abstract
The endocytotic activity of skeletal muscle fibres and its relation to the denervated endplate region has been studied using horseradish peroxidase (HRP) as marker for endocytosis. In muscles denervated for a short time period (10-20 days) HRP-uptake occurred in small segments of the muscle fibres near the centre of the muscle (endplate region). After long-term denervation (6-12 months) similar segments with high endocytotic activity were seen preferentially in more peripheral parts of the muscle fibres. Ultrastructural characteristics of segments with high endocytotic activity from long-term denervated muscle fibres include a proliferating transverse tubular system, HRP-containing bodies of different sizes with some very large vacuoles... (More)
The endocytotic activity of skeletal muscle fibres and its relation to the denervated endplate region has been studied using horseradish peroxidase (HRP) as marker for endocytosis. In muscles denervated for a short time period (10-20 days) HRP-uptake occurred in small segments of the muscle fibres near the centre of the muscle (endplate region). After long-term denervation (6-12 months) similar segments with high endocytotic activity were seen preferentially in more peripheral parts of the muscle fibres. Ultrastructural characteristics of segments with high endocytotic activity from long-term denervated muscle fibres include a proliferating transverse tubular system, HRP-containing bodies of different sizes with some very large vacuoles extending over several sarcomeres. These characteristics are similar to those described previously for HRP-uptake in the endplate region of short-term denervated muscle (Tagerud et al., J. Neurol. Sci., 75 (1986) 141) except that no recognizable endplate structures were observed in the present study. The results are discussed in relation to the fate of the denervated endplate and the receptive capacity for synapse formation in long-term denervated muscle. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Endocytosis, Muscle, skeletal, Denervation, Endplate, Exocytosis, Lysosomes, Reinnervation
in
Journal of the Neurological Sciences
volume
125
issue
2
pages
147 - 152
publisher
Elsevier
external identifiers
  • pmid:7807159
  • scopus:0028129211
ISSN
1878-5883
DOI
10.1016/0022-510X(94)90027-2
language
English
LU publication?
yes
id
b5b3555f-169f-4147-a6fa-7980348fedf6 (old id 1108484)
date added to LUP
2008-07-24 11:11:56
date last changed
2017-08-27 03:50:18
@article{b5b3555f-169f-4147-a6fa-7980348fedf6,
  abstract     = {The endocytotic activity of skeletal muscle fibres and its relation to the denervated endplate region has been studied using horseradish peroxidase (HRP) as marker for endocytosis. In muscles denervated for a short time period (10-20 days) HRP-uptake occurred in small segments of the muscle fibres near the centre of the muscle (endplate region). After long-term denervation (6-12 months) similar segments with high endocytotic activity were seen preferentially in more peripheral parts of the muscle fibres. Ultrastructural characteristics of segments with high endocytotic activity from long-term denervated muscle fibres include a proliferating transverse tubular system, HRP-containing bodies of different sizes with some very large vacuoles extending over several sarcomeres. These characteristics are similar to those described previously for HRP-uptake in the endplate region of short-term denervated muscle (Tagerud et al., J. Neurol. Sci., 75 (1986) 141) except that no recognizable endplate structures were observed in the present study. The results are discussed in relation to the fate of the denervated endplate and the receptive capacity for synapse formation in long-term denervated muscle.},
  author       = {Vult von Steyern, Fredrik and Libelius, Rolf and Lawoko, Grace and Tågerud, Sven},
  issn         = {1878-5883},
  keyword      = {Endocytosis,Muscle,skeletal,Denervation,Endplate,Exocytosis,Lysosomes,Reinnervation},
  language     = {eng},
  number       = {2},
  pages        = {147--152},
  publisher    = {Elsevier},
  series       = {Journal of the Neurological Sciences},
  title        = {Endocytotic activity of mouse skeletal muscle fibres after long-term denervation},
  url          = {http://dx.doi.org/10.1016/0022-510X(94)90027-2},
  volume       = {125},
  year         = {1994},
}