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Retinyl palmitate is a reproducible marker for chylomicron elimination from blood

Bitzén, Ulrika LU ; Winqvist, M; Nilsson-Ehle, Peter LU and Fex, G (1994) In Scandinavian Journal of Clinical & Laboratory Investigation 54(8). p.611-613
Abstract
To study the individual variation in chylomicron clearance rate, young healthy volunteers were given a p.o. dose of 50,000 IU retinyl palmitate in the morning to label their chylomicrons. Serial blood samples were then obtained in the time interval 4-8 h after retinyl palmitate intake, to closely monitor the clearance of retinyl ester from the blood. The procedure was repeated in an identical way two days later. The calculated individual halflives for retinyl palmitate clearance ranged from 1.54 to 9.90 h, i.e. a more than five-fold variation. The intraindividual variation was much less (relative SD 11%). Retinyl palmitate clearance (and probably chylomicron clearance) is, thus, relatively constant within the same individual on different... (More)
To study the individual variation in chylomicron clearance rate, young healthy volunteers were given a p.o. dose of 50,000 IU retinyl palmitate in the morning to label their chylomicrons. Serial blood samples were then obtained in the time interval 4-8 h after retinyl palmitate intake, to closely monitor the clearance of retinyl ester from the blood. The procedure was repeated in an identical way two days later. The calculated individual halflives for retinyl palmitate clearance ranged from 1.54 to 9.90 h, i.e. a more than five-fold variation. The intraindividual variation was much less (relative SD 11%). Retinyl palmitate clearance (and probably chylomicron clearance) is, thus, relatively constant within the same individual on different occasions but varies considerably between individuals. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Chylomicron remnants, retinyl esters
in
Scandinavian Journal of Clinical & Laboratory Investigation
volume
54
issue
8
pages
611 - 613
publisher
Informa Healthcare
external identifiers
  • pmid:7709163
  • scopus:0027944419
ISSN
1502-7686
DOI
10.3109/00365519409087540
language
English
LU publication?
yes
id
427ad278-d439-483a-a1ff-f747e9cdc78e (old id 1108535)
date added to LUP
2008-07-24 11:53:20
date last changed
2017-01-01 07:10:31
@article{427ad278-d439-483a-a1ff-f747e9cdc78e,
  abstract     = {To study the individual variation in chylomicron clearance rate, young healthy volunteers were given a p.o. dose of 50,000 IU retinyl palmitate in the morning to label their chylomicrons. Serial blood samples were then obtained in the time interval 4-8 h after retinyl palmitate intake, to closely monitor the clearance of retinyl ester from the blood. The procedure was repeated in an identical way two days later. The calculated individual halflives for retinyl palmitate clearance ranged from 1.54 to 9.90 h, i.e. a more than five-fold variation. The intraindividual variation was much less (relative SD 11%). Retinyl palmitate clearance (and probably chylomicron clearance) is, thus, relatively constant within the same individual on different occasions but varies considerably between individuals.},
  author       = {Bitzén, Ulrika and Winqvist, M and Nilsson-Ehle, Peter and Fex, G},
  issn         = {1502-7686},
  keyword      = {Chylomicron remnants,retinyl esters},
  language     = {eng},
  number       = {8},
  pages        = {611--613},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Clinical & Laboratory Investigation},
  title        = {Retinyl palmitate is a reproducible marker for chylomicron elimination from blood},
  url          = {http://dx.doi.org/10.3109/00365519409087540},
  volume       = {54},
  year         = {1994},
}