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Desmosomes--dual junctional principles of intra- and supracellular order in epithelial differentiation and tissue formation

Franke, W W; Nuber, Ulrike LU ; Schmidt, A and Schafer, S (1994) In Verhandlungen der Deutschen Gesellschaft fur Pathologie 78. p.8-14
Abstract
The cells of most normal and malignantly growing tissues are connected by "adhering junctions", i.e. distinct sites of "homotypic" contact between the plasma membranes of two cells of the same or a similar kind, associated on the cytoplasmic side by a dense plaque at which often bundles of cytoskeletal filaments anchor. Of the various types of adhering junctions desmosomes are characteristic of epithelia and carcinomas but also occur in some other cell types. Their molecular components have recently been identified and characterized by cDNA-cloning and sequencing. Unexpectedly, the molecular complement of desmosomes has been found to show certain differences in different epithelia, with particularly complex patterns in stratified squamous... (More)
The cells of most normal and malignantly growing tissues are connected by "adhering junctions", i.e. distinct sites of "homotypic" contact between the plasma membranes of two cells of the same or a similar kind, associated on the cytoplasmic side by a dense plaque at which often bundles of cytoskeletal filaments anchor. Of the various types of adhering junctions desmosomes are characteristic of epithelia and carcinomas but also occur in some other cell types. Their molecular components have recently been identified and characterized by cDNA-cloning and sequencing. Unexpectedly, the molecular complement of desmosomes has been found to show certain differences in different epithelia, with particularly complex patterns in stratified squamous epithelia as well as in tumors and cultured cell lines derived therefrom. In addition, molecular principles important in the assembly of desmosomes and in the specific anchorage of intermediate-sized filaments (IFs) at desmosomal plaques have been elucidated. The possible value of cell type-specific isoforms of desmosomal components as markers for the subtyping of carcinomas and the role of desmosomal cadherins during invasion and metastasis of carcinomas are discussed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Verhandlungen der Deutschen Gesellschaft fur Pathologie
volume
78
pages
8 - 14
publisher
Urban & Fischer Verlag
external identifiers
  • pmid:7534023
  • scopus:0028710033
ISSN
0070-4113
language
English
LU publication?
yes
id
1be47cef-ea4b-4bec-96b3-62681a5d9ac7 (old id 1108647)
date added to LUP
2008-07-23 08:56:05
date last changed
2017-01-01 07:11:59
@article{1be47cef-ea4b-4bec-96b3-62681a5d9ac7,
  abstract     = {The cells of most normal and malignantly growing tissues are connected by "adhering junctions", i.e. distinct sites of "homotypic" contact between the plasma membranes of two cells of the same or a similar kind, associated on the cytoplasmic side by a dense plaque at which often bundles of cytoskeletal filaments anchor. Of the various types of adhering junctions desmosomes are characteristic of epithelia and carcinomas but also occur in some other cell types. Their molecular components have recently been identified and characterized by cDNA-cloning and sequencing. Unexpectedly, the molecular complement of desmosomes has been found to show certain differences in different epithelia, with particularly complex patterns in stratified squamous epithelia as well as in tumors and cultured cell lines derived therefrom. In addition, molecular principles important in the assembly of desmosomes and in the specific anchorage of intermediate-sized filaments (IFs) at desmosomal plaques have been elucidated. The possible value of cell type-specific isoforms of desmosomal components as markers for the subtyping of carcinomas and the role of desmosomal cadherins during invasion and metastasis of carcinomas are discussed.},
  author       = {Franke, W W and Nuber, Ulrike and Schmidt, A and Schafer, S},
  issn         = {0070-4113},
  language     = {eng},
  pages        = {8--14},
  publisher    = {Urban & Fischer Verlag},
  series       = {Verhandlungen der Deutschen Gesellschaft fur Pathologie},
  title        = {Desmosomes--dual junctional principles of intra- and supracellular order in epithelial differentiation and tissue formation},
  volume       = {78},
  year         = {1994},
}