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Hepatitis C in Lithuania: incidence, prevalence, risk factors and viral genotypes

Ambrozaitis, Arvydas; Zagminas, Kestutis; Balciunaite, Gina and Widell, Anders LU (1995) In Clinical and Diagnostic Virology 4(4). p.273-284
Abstract
BACKGROUND: The epidemiology of hepatitis C virus (HCV) infection has been studied in many countries. However, little is known about HCV infection in Lithuania, a Baltic country, that was part of the former Soviet Union. OBJECTIVES: The aim of this study was to determine and evaluate the etiology of acute viral hepatitis, the risk factors for acquiring HCV in comparison to hepatitis B virus (HBV), seroprevalence of anti-HCV among blood donors and risk groups of the population in Lithuania. The distribution of HCV genotypes from Lithuanian first-time blood donors was also assessed. STUDY DESIGN: Sera taken from clinical viral hepatitis patients, blood donors, risk groups of population were investigated serologically. Patients with acute... (More)
BACKGROUND: The epidemiology of hepatitis C virus (HCV) infection has been studied in many countries. However, little is known about HCV infection in Lithuania, a Baltic country, that was part of the former Soviet Union. OBJECTIVES: The aim of this study was to determine and evaluate the etiology of acute viral hepatitis, the risk factors for acquiring HCV in comparison to hepatitis B virus (HBV), seroprevalence of anti-HCV among blood donors and risk groups of the population in Lithuania. The distribution of HCV genotypes from Lithuanian first-time blood donors was also assessed. STUDY DESIGN: Sera taken from clinical viral hepatitis patients, blood donors, risk groups of population were investigated serologically. Patients with acute viral hepatitis were interviewed to determine their risk factors for HCV and HBV. HCV genotyping was done by PCR using type specific primers. RESULTS: Acute hepatitis C accounted for 5.0-8.5% of reported viral hepatitis cases in adults in Vilnius. Of the acute hepatitis C cases, 37.0% was associated with blood transfusions before the implementation of screening of blood donors for anti-HCV and only 15.4% (2/13) after the screening was started. Anti-HCV was found in 2.2% of first-time blood donors, in 7.9% of commercial blood donors, in 13.9% of commercial blood plasma donors, in 48.3% of hemodialysis patients, in 29.4% of prisoners, in 9.4% of elderly nursing home residents, and in 7.9% of hemodialysis staff. The following distribution in genotypes were found: genotype 1b (54.3%), 3a (23.9%), 2a (10.9%) 2b (4.3%), 1a (0%), and double infection (6.5%). CONCLUSIONS: Lithuania is a country with a considerable hepatitis C problem. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Hepatitis C virus (HCV) infection, Antibody against hepatitis C virus (anti-HCV), Hepatitis C virus genotype
in
Clinical and Diagnostic Virology
volume
4
issue
4
pages
273 - 284
publisher
Elsevier
external identifiers
  • pmid:15566848
  • scopus:0029583995
ISSN
0928-0197
DOI
10.1016/0928-0197(95)00017-8
language
English
LU publication?
yes
id
f1726fd9-e990-4ec2-b0d2-1bc3e4e1b6f1 (old id 1108784)
date added to LUP
2008-07-24 16:31:03
date last changed
2017-03-12 04:16:03
@article{f1726fd9-e990-4ec2-b0d2-1bc3e4e1b6f1,
  abstract     = {BACKGROUND: The epidemiology of hepatitis C virus (HCV) infection has been studied in many countries. However, little is known about HCV infection in Lithuania, a Baltic country, that was part of the former Soviet Union. OBJECTIVES: The aim of this study was to determine and evaluate the etiology of acute viral hepatitis, the risk factors for acquiring HCV in comparison to hepatitis B virus (HBV), seroprevalence of anti-HCV among blood donors and risk groups of the population in Lithuania. The distribution of HCV genotypes from Lithuanian first-time blood donors was also assessed. STUDY DESIGN: Sera taken from clinical viral hepatitis patients, blood donors, risk groups of population were investigated serologically. Patients with acute viral hepatitis were interviewed to determine their risk factors for HCV and HBV. HCV genotyping was done by PCR using type specific primers. RESULTS: Acute hepatitis C accounted for 5.0-8.5% of reported viral hepatitis cases in adults in Vilnius. Of the acute hepatitis C cases, 37.0% was associated with blood transfusions before the implementation of screening of blood donors for anti-HCV and only 15.4% (2/13) after the screening was started. Anti-HCV was found in 2.2% of first-time blood donors, in 7.9% of commercial blood donors, in 13.9% of commercial blood plasma donors, in 48.3% of hemodialysis patients, in 29.4% of prisoners, in 9.4% of elderly nursing home residents, and in 7.9% of hemodialysis staff. The following distribution in genotypes were found: genotype 1b (54.3%), 3a (23.9%), 2a (10.9%) 2b (4.3%), 1a (0%), and double infection (6.5%). CONCLUSIONS: Lithuania is a country with a considerable hepatitis C problem.},
  author       = {Ambrozaitis, Arvydas and Zagminas, Kestutis and Balciunaite, Gina and Widell, Anders},
  issn         = {0928-0197},
  keyword      = {Hepatitis C virus (HCV) infection,Antibody against hepatitis C virus (anti-HCV),Hepatitis C virus genotype},
  language     = {eng},
  number       = {4},
  pages        = {273--284},
  publisher    = {Elsevier},
  series       = {Clinical and Diagnostic Virology},
  title        = {Hepatitis C in Lithuania: incidence, prevalence, risk factors and viral genotypes},
  url          = {http://dx.doi.org/10.1016/0928-0197(95)00017-8},
  volume       = {4},
  year         = {1995},
}